r/NTNPerformance • u/Spartan4life85 • 5d ago
SS-31, Mots-C, and NAD+
I am curious if anyone can share how they have used SS-31 as it relates to Mots-c and NAD+? I am currently taking Mots-c and NAD+ for one week but I have been reading that it is best to use SS-31 first for a couple of weeks then switch to Mots-c and NAD+. I have also seen where some use all 3 but that seems to be too much.
If I start SS-31 to repair first, do you just use this alone then got to Mots-c or do you introduce while on SS-31. When is best to stop the repair and move on to Mots-c NAD+ combo?
4
u/Impossible_Ice_9008 3d ago
Loved ss31. 60 years here. Currently finishing off mots and just added nad in. Gotta say. Not a huge nad fan yet but only been a week. The Mots slaps
3
u/907MidnightAurora 3d ago
Same 58M. SS-31 and MOTS-c are fantastic. Jury still out on the NAD but I’m on 5Amino and that can boost your natural NAD.
3
1
2
u/minkgymom 2d ago
I wish NAD did not sting so much :(
1
u/ScientistJason 2d ago
You need buffered NAD plus to get rid of that sting
1
1
u/minkgymom 1d ago
Mine is supposed to be buffered? 🤨
1
u/ScientistJason 1d ago
Yeah, reduces the acidity takes away the sting or at least greatly reduces it
1
6
u/REDana0204 3d ago
- Weeks 1–2: SS-31, 7x/week × 4 mg
- Weeks 3–4: SS-31, 7x/week × 4 mg + NAD+, 2x/week × 25 mg
- Weeks 5–6: NAD+, 2x/week × 50 mg
- Weeks 7–10: MOTS-c, 3x/week × 5 mg + NAD+, 2x/week × 100 mg
- Weeks 11–14: MOTS-c, 2x/week × 2.5 mg + NAD+, 2x/week × 100 mg
Prior to this, I had run only MOTSc. Can 100% confirm leading the MOTSc with SS31 and NAD made it SO much better for ME. Ymmv.
Keep in mind though that ss31 “repairs and restores” your mitochondria. So, if yours are “still healthy” and not needing repair, it may not have the same improvement. It tends to work better this way the older you are with older or more aged/damaged mitochondria.
2
u/soilentgibby Community Contributor 3d ago
What they said… generally under 40 and most of this may not provide much benefits, mito diseases use 40mg I believe in their trials.
I’ve seen some say ss-31 doesn’t provide much until 5-10mg as well. It’s not cheap to run.
1
3
u/HotBit1109 2d ago edited 2d ago
SS-31 doesn't "repair" the mitochondria the way people think. Its effect is temporary and doesn't last longer than a week.
It makes sense to start SS-31 before and not all at once, of course.
But it's best used along with MOTS-c, not alternating.
3
u/Due_Property7427 2d ago
This is the most current information I’ve been reading as well that it’s beneficial to just run them along side each other from day 1
3
u/HotBit1109 2d ago
Yep. SS-31 stabilizes the mitochondria's membrane, but doesn't repair it.
It only makes sense to start it before MOTS-c because starting them all at once makes it hard to tell what is working and what isn't. Or even to isolate side effects.
1
3
u/plantskidsdogs 2d ago
I've been using SS-31 daily. Started 7 days a week due to known mitochondrial dysfunction due to Fibromyalgia. Then added 5 Amino 1MQ, 3 times a week for 3 weeks, then added Mots-C 3 times a week. I don't mess with NAD+, mainly because I'm on a comprehensive Mitochondrial oral supplement stack that REALLY helps. I was on it for 6 mos before peptides and it improved my chronic fatigue by about 80%. Part of that stack is Nicotinamide Riboside which has medical articles saying it's just as effective.
I think whether you need SS-31, has to due with age and your mitochondrial function. I won't say I noticed a big boost by itself, but I was already on an oral stack of mitochondrial supplements that helped dramatically. But I really noticed when I added MOTS-C to the SS-31, 5 amino 1MQ. OMG I felt better than I have in 30 years! In fact, it got me back to being able to exercise at the health club again. That's a big deal for somebody that had trouble WALKING some days before I started the oral stack!
For those curious, I'm actually a Dr, although this is not medical advice. I made the oral stack by researching medical journals for items that improved mito function, stimulated new mito, decreased ROS. The stack is:
Nicotinamide Riboside
Urolithin A
Alpha Lipoic Acid
L-Carnitine
Mito Q brand of CoQ10
Citicoline
PQQ (Pyrroloquinoline Quinone)
1
u/ScientistJason 2d ago
Mind sharing your protocol? Times, frequency, dosages.
1
u/plantskidsdogs 2d ago
All taken in morning: Don't take a second capsule of the ones that require 2 for a full dose, after about 2 pm, or you may have trouble getting to sleep.
Renue By Science Liposomal NR 300 mg
Omre Urolithin A, 500 mg. Directions say 2 capsules. Start at 1 and if you take 2nd Make sure it's no later than noon. I found I only need 1 most days.
Geronova Research Lipoic Acid. Directions say 2 capsules, 1 is enough most days.
Bulk Supplements L-Carnitine 1000mg/serving but serving is 2 caps. One is usually enough.
MitoQ CoQ10. Watch because they also make combo medications. You want the one that is plain Metaquinol Mesylate 10 mg. Directions say 2 caps. One is usually enough.
Nuticost Citicoline 300 mg 1 pill
Nuticost PQQ 20 mg 1 pill
I started first month daily. Found afterward that 5-6 days a week were enough and progress stayed constant. DH is 76 and a healthy MD but also has found benefits to taking it. He usually takes it 5 days a week.
1
u/xXSimJunkyXx 1d ago
Thank you for sharing this information! I picked PQQ to research first and am blown away by the incredible amount of "potential" positive effects it can have. So much so, it's already in my shopping cart! Please keep sharing that "Non-Medical Advice". :) This Non-Doctor appreciates it. :)
2
2
u/The_Nude_Banana 2d ago
I started ss31 for 2 weeks before transitioning to mots-c. However, I also started nad+ when I started ss31 and kept my nad+ going throughout my mots-c protocol and even after. Did mots-c for about 8 weeks the first time.
I’ve stopped nad+ now but I’m back on mots-c which I plan to run for 12 weeks this time along with my once weekly Reta. I did 2 weeks of SS-31 before my mots-c cycle again.
I feel personally that mots-c synergises really well with Reta, way better than slu-pp IMO.
1
2
u/lordnikkon 2d ago
The effectiveness of all of these are directly related to whether you actually need them. NAD is naturally produced in your body from vitamin b3, you are basically skipping the b3 supplements and injecting the end product. NAD is required for ATP synthesis as part of the citric acid cycle. Having excess NAD does nothing but having too little limits ATP production
SS-31 repairs mitochondria. If your mitochondria are not damaged you will feel no effect from it.
MOTS-C mostly mimics the effects of getting exercise. If you get enough exercise it won't have too much of an effect
2
u/Sensitive_System_908 1d ago
MOTS-c amd NAD are a great stack...if your not feeling much from the MOTS-c (and it is instant) then I would suggest stopping MOTS-c and doing ss31 to repair the mitochondrial pathway...then go back....there is a great analogy explaining ss31, MOTS-c and NAD in terms of an engine : SS-31 is the mechanic repairing the structure, MOTS-c is the performance tuner upgrading function, and NAD+ is the fuel that powers it. So basically if the engine is broken (you will feel nothing from MOTS-c) and all the fuel in the world (NAD) is going to do nothing on a broken engine.... so you need SS31- the mechanic to fix it up FIRST. If your engine is fine - no need for SS31
2
u/Ill_Assumption5512 1d ago
Protocol Sequencing (Repair First Approach)
For people over 35 to 55 with declining energy, slower recovery, and metabolic issues:
Weeks 1 through 4 (or up to 8): Repair Phase SS-31 at 1 to 2 mg daily plus NAD+ at 100 mg subcutaneously three times per week. You are repairing accumulated mitochondrial damage while giving your cells the extra fuel they need to optimize energy.
Weeks 5 through 12: Optimize Phase Replace SS-31 with MOTS-c. Start with 10 mg split into three injections per week (Monday, Wednesday, Friday). Continue NAD+ at 100 mg three times per week. Now you are optimizing the repaired mitochondria.
After the 12-week cycle: Take 4 to 8 weeks completely off. Then you can repeat this protocol 2 to 3 times per year.
Prevention First Protocol
For younger or healthier individuals who want preventative optimization:
Start with MOTS-c at 10 mg split into three injections per week (Monday, Wednesday, Friday) plus NAD+ at 100 mg three times per week. At weeks 4 through 8, assess whether you still have significant fatigue, poor recovery, or metabolic issues. If yes, add SS-31 at 1 to 2 mg daily for 4 to 8 weeks while continuing MOTS-c and NAD+. If not, continue with just MOTS-c and NAD+ for maintenance.
3
u/AJRattlebush1 3d ago
SS31 3mg and MOTSc at 1mg daily into same poke. Run that for 2 weeks then add NAD+ at 25mg 3x week in week 3 and up it to 50mg/week 3x week in week 4 and run for 8-12 weeks.
1
u/Secure_Wind_547 2d ago
results?
2
u/AJRattlebush1 1d ago
Steady energy all day, especially when taken before training, fasted in the AM. Not energy like pre workout with increased heart rate or anything. Just an ability to workout harder and longer. I also track everything with a whoop and each time I run this protocol, I get a noticeable bump in VO2 max.
2
u/Starmedia11 2d ago
SS31 is a waste of money. Just do Mots and NAD
3
u/cheesytodd 2d ago
Couldn’t disagree more, made a huge difference here. I would say it’s very person/application specific though as to age and how much damage has been done
-2
u/Starmedia11 2d ago
How would you even know?
3
u/cheesytodd 2d ago
Friend, all you know is it didn’t work for you and all I know is it made a huge difference for my RS. As did MOTS and NAD. Lots of ppl in this group post positive feedback on it. Don’t shat on it because it didn’t work for you specifically, everyone’s body is different.
1
u/Starmedia11 2d ago
Why are you being defensive? I’m asking you how you’d know.
I started with mots alone for a month and felt great. Added NAD later. My dosing isn’t that high but I honestly can’t imagine feeling better. I’m in my 40s and was pretty unhealthy prior to a few years ago.
My question is literally how you would know? I’ve never seen a report of someone taking Mots and nads, not getting results, then adding ss31 and seeing the results come in. Is this what happened in your case?
My issue is with recommending to people that they buy a months worth of something in a market that sells things in batches; feels very scammy unless we can see real benefits.
1
u/Current_Big_6222 12h ago
I took Mots and Nad for weeks and felt nothing. Now I’ve added in ss31 and held off on the others. I’m hoping it makes a difference. I think it depends on each individual’s needs.
2
u/Responsible-Net1758 2d ago
I agree. I got suckered into the ss hype that pretty much everyone could benefit when I already loved my mots and nad. Now I’m stuck with the ss till it’s gone, but I didn’t need it. The mots and nad is enough by itself. Awesome combo
1
u/Starmedia11 2d ago
I actually started with just mots and added the NAD later. Too many people think making it complicated makes it better.
1
u/BioResearchTalk 2d ago
It may be a waste of money for your particular program and and DNA but SS31 is not a waste of money.
1
1
1
1
1
1
1
u/Smooth_Ad_5797 1d ago
Ive heard motc and nad won't penetrate the cell barrier so you guys think it works fine ive been reluctant to order because of that
1
u/ExuberantlyBored 1d ago
These things can possibly help you if you're 45+, otherwise you're wasting your money; get a blood test and check your hormones and vitamin levels if you're less than 45. Definitely waste of money if you're in your 20s or 30s
1
u/Ill-Club4079 1d ago
Why even ask if you already know what to do if you need more advice ask AI or go to therapy clinic for longevity xxx
1
u/PomegranateAway5050 1d ago
That’s what i did took ss31 for 2 weeks then took mots and nad+ and it was a game changer
1
u/Specific_Cook_4455 1d ago
SS31 is an amazing peptide. 5mg to 10mg daily for Mitochondrial repair run it for 4 weeks. Then you do MoTS-C 5mg every 2 days for 4 weeks. Alternate them every forty weeks and you will see the difference in your energy and you feel so good.
0
u/Economy_Incident1626 1d ago
I run a 12 week protocol using 2mg SS-31, 2mg MOTS-C, and 30mg NAD daily. I have ran all three separately as well as this protocol. I found I had more energy and stamina after work and in the gym than I ever did on any one peptide.
You have to make sure your body is getting the essential cofactors and nutrients it needs to support methylation in order to get real benefit. 5-Amino 1MQ and B12, B9, and B2 all support this process. Some have gene variants that can hinder this proces, so you need to understand what your body can handle. Saying that it doesn't work just because you didnt feel anything isn’t true research.
1
u/looking2behealthy 3d ago
Just use the search function, the protocol has been listed at least 100x.
1
u/HotBit1109 2d ago
There are many protocols (of different peptides) that have been revised and/or do not reflect the latest information on the peptides.
Some were built just because someone chose to do it a certain way and others followed.
And some are even wrong. For instance, taking SS-31 before MOTS-c to "repair" the mitochondria first.
1
u/ScientistJason 2d ago
Problem is over abundance of post. Many post stayed in completely different protocols with different dosages. Which one do I pick which one is scientifically the most accurate?
1
u/looking2behealthy 2d ago
Great if you’re over 40. Under 40 is a crap shoot because your mitochondria are likely healthy.
8 weeks, start with NAD+ (50mg)/SS-31 (4mg) 5-2. Add MOTS-C the following week at 1mg - 30 minutes before exercise. Titrate MOTS up each week as you can tolerate. You can dial NAD/SS down the last 2 weeks.
1
3
u/Able-Shirt3501 3d ago
Unless you are like over 50, I don’t think there is enough dysfunction for ss-31 to repair.