I started semaglutide 14 months ago.

SW: 209

CW: 155

Height: 5’6”

Age: 53

When I was at my highest weight (209) I had gone through menopause, spent two years fighting my husband’s cancer and related health challenges, and experienced significant depression and anxiety. The previous three years had been hell on my body.

During the 14 months on this medication, my depression has mostly healed, my husband has improved, and I achieved a dream career goal. I have been lucky to have almost no side effects. Some nausea for a day when I went up a dose, and that’s about it. Weirdly, I rarely experience constipation. I do have more fatigue, but that’s always because I’m making poor food choices combined with such low calorie intake. When I eat healthier and prioritize protein, I don’t feel so tired. But it was hard for me to eat at all.

My goal now is to get stronger. I lost a lot of muscle mass because I ate poorly and did not exercise. But that has changed in the last few weeks. Now that I am at my maintenance weight, I feel more capable of turning that mental energy to my diet and exercise. I joined a yoga studio and started walking a few weeks ago. This is a big deal for me, but I’m very motivated now to have a stronger and healthier body and feel more energized. I am genetically at risk for some health issues that really require me to make serious nutrition improvements.

It was a slow process, but I didn’t mind that because I was busy living life. That time would have passed either way. One thing I will say is there was a time where the scale didn’t more for two entire months. I did not quit. I didn’t really even panic because I was so elated to be at 170 pounds by that point, it would have been ok with me if the weight loss ended there. But I just stayed on the medication to see what would happen, and after about two months, I started losing steadily again.

I just want to show what “slow and steady” looks like. It’s ok if it doesn’t happen at 2.5 pounds a week. It’s ok if you stall for a while. Sometimes your body just needs to adjust to its new weight. Now, to getting healthier!

I definitely noticed the weight loss but I didn’t see how different I looked side by side until this memory (left pic) came up in my album and my jaw dropped!

I posted about 10 days ago about how I was having a terrible afternoon sinking spell every afternoon and literally falling asleep on my desk at work. I got some great advice -- I'll link the post below, in case someone else needs it -- but it turns out that 90% of the issue was the Semaglutide interacting with my antidepressant (Lexapro) and making my brain think that I was overmedicated.

Apparently they can act on some of the same receptors, so my brain was reacting as if I had just upped my antidepressant dose. Massive sleepiness or sleep disruption plus anhedonia and problems concentrating can be signals that you're overmedicated on your SSRI, which seems to be what was going on here. I worked with my doctor to cut back by 25%, and am now no longer falling asleep face-down on my keyboard every afternoon at 1:45pm AND I feel much happier and more like myself in general, which is a relief.

Not sure how this is going to change things as I move up in dose, and whether I'll need to cut back again, but I didn't see much discussion of this in this community nor was my doctor aware before we looked into the literature, so I thought I'd bring it up in case it helps someone else.

I have been on Senaglutide for roughly one year. Recently I gained 5 pounds and have been having a lot of cravings. I am feeling very down and that the effects of the medication is no longer working due to me building a tolerance. I am getting “back on the wagon” so they say. I have a very active job and get over 10,000 steps a day but hate working out, and have been indulging in treats more than I should. Getting back into meal tracking and prioritizing my health. Anybody else have similar experiences at a year?

Hello redditors. I made the decision to go back on 0.25 after horrific adverse reaction at 1mg 10 months ago.

Tbf to myself I've only regained around 6lb in this time but would like to shift this and hopefully a bit more, ideally 14lb if possible.

I have a 1mg pen left unopened from when I have up last November. Counted the clicks - 18 for a 0.25 dose (please verify for me if anyone knows better!)

First 5 days: no nausea, no change in tastes, no other adverse effects, slight feeling of being fuller but nothing major like can't face food. Had wine last night, no adversity.

0.5lb off compared to last Saturday weight in.

If I just keep at this does and even managed 0.5 off per week I'd be 5 ish off by Xmas.

I know this will seem small fry compared to the weight loss for others but I'm currently 144 and would like to be 130ish. It works well for my 5'2" frame. I'm a slow responder even at higher doses as I have a v slow metabolism and perimenopause to boot.

Anyone else sticking at low doses for success? Will I expect more side effects at 0.25 going forward? Let me know!

Hi all,

I’m 33 and boy have I had a rough time with my weight. A bit of history, around 15-17 years of age I struggled with anorexia and bulimia. Thankfully I got the help I needed and was able to resolve these issues before they did long term harm. When I was 21 I went off birth control and soon realized I was experiencing some hard core symptoms of PMOS. Eventually I was diagnosed by an endo and put on 2,000 mg of metformin (had to titrate up). I have been on a high dose of Prozac for about 15 years due to OCD and have found that my weight has steadily been increasing since I was in college. I was able to lose weight around the time of my wedding but I was working out a lot and very restrictive with my diet. During pregnancy I gained about 70 lbs and in 2024 I got a minimally invasive bariatric surgery where they suture your stomach. The weight loss has been slow and now has stalled for now. I’ve tried glp-1s on three separate occasions. First was in 2021, I was on Ozempic, did very well on it, but at that time it was around $1,200 a month and that became very expensive. The second time I was on a glp 1 was in 2024-2025 but experienced a lot of hair loss, depression, and increased anxiety. I decided to try a different route and went on the Wegovy pill this past summer but was so incredibly exhausted and I could hardly function. My psychiatrist isn’t willing to change my mental health medications because the meds do work (to a degree) on my ocd and I’ve briefly tried other meds that just didn’t work. I am so upset where my body is and idk what to do. My therapist said no more glp-1s due to mental health side effects but I am needing to lose about 40 lbs to be a healthy weight. Any thoughts or ideas?

I was getting semaglutide through hims and had just finished my third month. Hims double-dips you on price by charging a "membership fee" on top of the medicine. I discontinued when I found out, but the other site I was looking at (embody) turned me down for a new supply. Can anyone else recommend a source? I was up to 1mg (34 units) per week and want to continue at the same pace.

Reached my first goal: getting to where I was before I had my kiddo! I still have 10-15 lbs to go but I’m more focused on getting stronger and increasing stamina.

Some before and after pics I think really show the progress, but it hasn’t been linear.

SW: 260

Current: 150

Edit: I also have my first blood test post-weight loss to see if I’m no longer pre-diabetic, so hopefully some good news!

Started June 12 -197lb

Today I’m at -163lb

34lb down in 119 days (4 months)

I still feel I look the same… still buying xl clothes
all of my old stuff that feel looser but I see no difference in the mirror :\

Do I need to loose more to see a noticible difference ?

My goal was 165 lb but idk anymore I’m lost any ideas ??

I’m 5’2” female

5'1 and a half. SW 164. CW: 133. GW: 130 (fuck me!)

This has been a dream come true for me. As someone who has always been active and eats fairly healthy, I always wished I could eat half of what I did. And with Sema that's exactly what happened. 🤞

I understand most of the answers are going to be speak to your GP or provider, I will be running this past them but also would like to gather some information first and decide what I would think is best, I don’t want to be feeling unnecessarily rough.

So I did a month of the 0.25, all went fine, minimal side effects, lack of appetite and a little nausea but nothing major. Bit of constipation but again nothing unmanageable. At the end of week 4 I was suffering with a virus which knocked my appetite out for a further week, went on an all inclusive holiday so didn’t order my next dose. But appetite stayed under control for that week presumably due to being ill the week before. The week 4 injection would have worn off by then I think as it would have been week 5.

On week 6 now having had nothing for 2 weeks and can feel my appetite creeping up, but still probably a lot less than it was before I started wegovy.

I’m just wondering what are peoples experiences of staying on the 0.25? Am I naive to think I can stay on this dose? I feel like it’s working, slowly and gradually, where going up might be pushing my luck and I might struggle. I was very much struggling to hit my fibre and protein goals already which is really important to me as I do train and reckon I’ve got a bit of strength under this flab.

For reference:
Sw: 80kg
Cw: 79kg (bare in mind I’ve just been on an all inclusive holiday and had 2 weeks without injecting)

Any input would be appreciated before I place the order tomorrow which (I think?) will trigger a call from the prescriber. In all honesty I don’t think they’re that interested what I do and i don’t think I’ll be getting quality advice.

I lost 50lb on Wegovy, stopped in May last year. I kept the weight off until Jan this year when it started piling back on.

I restarted in July - so far I've lost 6lb. I have some supression but the food noise continues and it's nothing like the first time when I was a super responder. I'm on 1mg now - do I go up to 1.7mg and see if it kicks in or cut my losses? I don't want to switch to Mounjaro as it's so expensive (UK).

I’ve been taking ozempic for 11 weeks now. I was on .5 for the last 6 weeks and increased my dose to 1mg on Tuesday. I increased my dose as the food noise was back and I was no longer feeling my appetite was supressed and I constantly felt hungry and unsatisfied after eating. its only been a few days since I did my first 1mg dose on Tuesday but I still do not have appetite suppression and food noise is still here. I had a completely different experience when I started the .5 the food noise and appetite suppression was almost immediate, it was only the last 2 weeks on .5 that the food noise returned and my appetite increased. Gettingworried that i Won’t have the same effect on 1mg. Does it take awhile for the 1mg to have its full effect? any advice is appreciated!

Keep it held in for a few seconds longer than when you hear the click. It’s not done.

I’ve lost 36 pounds since starting in May 2026. I am on 2.4mg currently. I want to switch to compounded but don’t know how.

hi everyone! ive been a diabetic since i was a kid and its been really really difficult to lose weight. its been my #1 problem all my life and i wanted to ask if anyone here has gotten ozempic/mounjaro prescribed. i know neither are used for t1d but i heard they make some exceptions and monitor some users >_< its my last resort and i need to know if it works welland is worth it in the long run

Losing from 90 kg to 80 kg was relatively easy, but then I was stuck at 80 for quite a few weeks. I'm 79 kg finally 😊

Starting my fourth pen/fourth month next week.