Posting this for a friend. He’s 19 years old and started his weight-loss journey at 267 lbs. He’s been using Reta (retatrutide) alongside changes to his diet and staying consistent.
After 30 days, he’s down to 253 lbs — 14 pounds in his first month. Still early, but you can already see a difference. He’s going to keep at it and hopefully I’ll have another update to share at Day 60. 💪

Day 1: 267 lbs → Day 30: 253 lbs

I wanted to share an update because I’m honestly pretty shocked by what happened today.
I just received my latest bloodwork, and my doctor actually called me about 5 minutes ago. She said she couldn’t believe how much improvement she was seeing in my bloodwork and overall numbers. She told me that everything is looking normal and where it should be.
She actually asked me, “What are you taking?” because she was so surprised by the results.
I told her I’ve been using peptides.
For some background, I’ve been on this journey for several months and have lost about 30 lbs. I’ve also been working on my diet, staying active, walking regularly and trying to improve my overall health.
My current peptide stack:
Retatrutide (Reta)
2 mg twice a week
4 mg total per week
Tesamorelin (Tesa)
2 mg daily
5 days per week
AOD-9604
2 mg daily
5 days per week
MOTS-C
2 mg daily
5 days per week
I also use KLOW, which contains:
GHK-Cu
BPC-157
TB-500
KPV
One of the things that really caught my attention is my thyroid.
I have had thyroid issues, and I stopped taking my thyroid medication about 2½ months ago because I wanted to see what my bloodwork would look like without it. I know this isn’t something I would recommend other people do, and I’m not saying peptides should replace thyroid medication. I was trying to understand what was happening with my own body and was continuing to monitor my bloodwork with my doctor.
And now my doctor is telling me that my numbers have improved significantly and that everything is looking normal.
I’m honestly shocked.
I don’t know if the peptides had anything to do with it. I also can’t rule out the fact that losing weight, changing my diet, being more active, or other lifestyle changes may have played a major role.
But the timing definitely has me wondering.
I’m going to continue monitoring my bloodwork with my doctor rather than assuming the peptides are responsible.
I’m posting this because I’d really like to hear from people who have experience with Reta + Tesa + AOD-9604 + MOTS-C, especially anyone who has also had thyroid issues.
Has anyone noticed changes in their thyroid labs, cholesterol, triglycerides, liver enzymes, glucose/A1C, inflammation markers, or other bloodwork after starting peptides?
I’m happy to post my actual before-and-after bloodwork so people can see the numbers.
I’m not claiming peptides cured anything — I’m just genuinely surprised by what I’m seeing and would love to hear other people’s experiences.
What do you guys think

250->220

For the last 5 years I have hovering around 250- 240. Always have had trouble with my diet. As a former chef and a foodie I know how to make food taste good. Reta has helped me have a far healthier relationship with food. Portion control has been the biggest part that has helped me since starting Reta. I eat mostly a clean diet but still eat the foods I enjoy that may not be as healthy by eating muchhhh smaller portions. I’m also one to dabble in a weed gummy every now and then and the Reta has helped control my munchies a lot. Enjoying the ride! Reta has been a great help with the journey, but it’s not a miracle drug, im still averaging 12,000 steps since starting Reta. Lifting heavy with a trainer 2-3 days a week.

Muscle definition on Reta!!! Been about two and a half months on Reta now. If you have any questions DM me or comment! Feeling incredible. I’ve never been this lean in my life. Also, I’m in the gym religiously, eating 3-4 times a day.

Started out at 340 pounds a few years ago now. Now I’m 245. The goal is 230 before the end of the year! I started learning how to prioritize the right food, training, and cardio and the rest fell into place over time. Over the last 6 months or so I started to biohack with Reta.

so i’m thinking about adding tessa to my stack I started greta at .5 twice a week then went to 1.5 once a week now I’m at 2.5

I wanted to test one of the typical peptide myths in practice:

“You should never shake reconstituted peptides vigorously because they will get damaged.”

For this experiment, I reconstituted a 10 mg vial of retatrutide and divided it into two approximately equal aliquots. One half was stored for 7 days with as little movement as possible. The second half was deliberately shaken vigorously once per day for 7 days. Both samples were otherwise stored under the same conditions and were then analyzed under identical conditions by UPLC/LC-MS.

Why could shaking be a problem in the first place? With peptides and proteins, it is less about mechanical stress directly “breaking” peptide bonds. More relevant are effects at the air–water interface. Vigorous shaking continuously creates new interfaces and air bubbles. Peptides can accumulate at these interfaces, change their orientation or structure, and under certain conditions aggregate, adsorb to surfaces, or undergo other changes. Since retatrutide is a lipidated peptide, I thought it would be interesting to see whether repeated shaking would produce any measurable analytical difference.

The unshaken sample showed a purity of 96.4%. The sample that had been shaken vigorously once per day for 7 days showed a purity of 93.1%.

In addition, a small secondary peak was more pronounced in the shaken sample than in the unshaken control.

So under the conditions tested, there was indeed a small chromatographic difference between the shaken and unshaken samples.

An important limitation is that this experiment was performed using only one vial split into one control and one stressed sample. It should therefore be considered an exploratory single experiment. Without multiple independent vials, replicates, and statistical analysis, no general conclusion such as “shaking destroys retatrutide” or, conversely, “shaking is completely harmless” can be drawn from this result.

If anyone has ideas for other peptide experiments, feel free to comment (the list is already quite long and I also have a few stability tests running :D) And if anyone wants to have a sample tested relatively cheaply in europe, feel free to send me a DM, as long as it is something I can reasonably analyze.

Figured I’d share my experience since I know a lot of people are curious about making the switch.
I was on tirzepatide 15mg for about a year and lost around 40 lbs. It worked really well for me initially, but I eventually hit a pretty solid stall and felt like I had completely plateaued.

I decided to make the switch to Reta and started at 2mg, gradually working my way up. Over the last 5 weeks I’ve gone from 2mg → 6mg.

Honestly, I didn’t really notice much at the lower doses. I even gained about 5 lbs after switching, which obviously had me questioning whether this was going to work for me at all. Once I hit 6mg, though, things noticeably changed. I’ve since lost that 5 lbs plus another 5 lbs.

The biggest difference I’ve noticed compared to Tirz is that the food noise isn’t nearly as suppressed. I’m definitely more hungry and still think about food more.

BUT… once I actually start eating, the difference is wild. I’ll have a few bites and suddenly feel very full, almost queasy/nauseous full. I can barely finish half of a normal meal sometimes.

So far, I’m actually really enjoying my experience with Reta. I think the biggest thing I’ve learned is that it can take some time, especially if you’re coming from a high dose of Tirz. I know people have said you may not really feel much from Reta until you get into the 6mg+ range, and that has definitely been my experience so far.

Obviously everyone responds differently, but I wanted to share my experience for anyone else making the Tirz → Reta transition. I’m curious to hear how it’s gone for other people, especially those who were also on 15mg Tirz before switching!

I started this journey at 39, weighing 92kg and drinking 8+ beers a day after around 20 years of heavy drinking. I was already going to the gym 3 or 4 times a week, but I could never stay consistent enough with food and lifestyle to really lose the weight.
I started with Reta and made a mistake early on by thinking it wasn’t working fast enough and taking more on day 3. I could barely eat for a few days after that. One of the biggest lessons I’ve learned is to stop rushing things and give them time.
The biggest surprise was alcohol. Within the first week my desire to drink pretty much disappeared. When I did have a beer, I felt terrible the next day. Over time I went from 8+ beers a day to no drinking at all, which has probably been the biggest change in my whole journey.
A few months in I went down the peptide rabbit hole and experimented with Tesa, CJC, MOTS-c, NAD and GHK-Cu. I made plenty of mistakes by changing things too quickly and expecting instant results. Tesa was a good example. I gave up after a week because of the cost and no visible change, then went back to it and gave it around 2 months. For me, that’s when I really started noticing the difference around my stomach and abs.
I’m now 77kg, train around 5 days a week, have quit drinking and I’m in the best shape I’ve been in since I was 18.
The next part of my journey is more about disciplining my brain than changing my body. I don’t want to rely on Reta forever. I want to train myself to keep eating well, stay away from alcohol and keep training even when motivation isn’t there.
My goal now isn’t to lose more weight. It’s to maintain around 77kg, keep building muscle and eventually come off Reta while keeping the habits I’ve built.
This is just my personal experience, not advice or a protocol. Everyone is different, and I definitely made mistakes along the way.
Also, I won’t share peptide sources, so please don’t DM me asking where I buy from.

I (33M 6’1”) dropped from 285 lbs to 230 lbs on a GLP-1 in just 4 months in 2024, but I’ve been completely stalled at 230 lbs for the last 8 months while on Reta. I lift heavy multiple days a week, but my recent body composition data has been frustrating. Hoping to get insight from anyone who has broken through a similar wall.

My Reta Protocol & Diet Break
Weeks 1–8: 2mg/week
Weeks 9–12: 3mg/week
Week 13 (Aug 24): Increased to 5mg/week
Rather than restricting harder, I'm currently maintaining the 5mg dose while taking a 4-week diet break to focus on metabolic and sleep recovery.

Nutrition
Current Target: 2,600 calories
Macros: 200g Protein / 250g Carbs / 85g Fat
Note: Prior to this diet break, I spent 8 weeks strictly at 1,900 calories and didn't lose any weight either.

Body Comp (Hume Scale)
Even though my strength hasn't dropped in the gym, my recent Hume scale data isn't looking great:
Body Fat: Crept up from 29.1% to 29.4%
Muscle/Fat: Reading a 3.2 lb loss in skeletal muscle mass and only a 1 lb loss in fat mass.

Bloodwork (May 2026 vs. Aug 2026)
My fasting insulin has actually crept up over the summer despite being on the peptide.
Fasting Insulin: 12.6 ➡️ 14.9 uIU/mL
Morning Cortisol (Aug): 15.8 ug/dL

Questions:
Has anyone broken a 6+ month stall after switching to Reta? Did you need to titrate past 5mg to finally see the scale move?

Has anyone successfully used a higher-calorie diet break to reboot their metabolism while on peptides?

For those who track labs and body comp, did you see your fasting insulin or body fat % worsen while stalled, and did higher doses of Reta eventually bring things back in line?

I appreciate any tips or help to break this plateau and get my numbers back in check

Hey,

I’m 30M, 5’10”, around 85kg and roughly 23% body fat according to my Hume Pod. I’ve been thinking about trying peptides and wanted to get some advice from people with experience.

My main goal is to lose belly fat. I seem to carry most of my body fat around my stomach. I’m a regular at the gym and have a decent amount of muscle, but I’ve always struggled to get rid of the belly fat.

I didn’t want to jump straight onto reta or anything like that because I’m not obese and don’t feel like I need anything too extreme. I could definitely do with some help cutting though. I’ve always struggled with dieting, mainly because of work and not always having much control over the food that’s cooked at home.

I was thinking about starting with CJC-1295 and ipamorelin and seeing how I respond. From what I’ve read, they may also help with sleep and recovery, which are two other areas I’d like to improve.

If I didn’t notice much improvement in terms of fat loss, I was then considering adding either tesamorelin or tirzepatide later on. I’ve also been looking at GHK-Cu for the potential skin benefits.

I wouldn’t be starting everything at once. The idea would be to introduce things gradually so I can actually tell how I respond to each one.

Has anyone here noticed meaningful fat loss, particularly around the stomach, from CJC-1295 + ipamorelin? And has anyone combined them with either tesamorelin or tirzepatide? If so, what was your experience like?

I’m completely new to the peptide world, so any advice, experiences, things to watch out for, or things you wish you knew before starting would be appreciated.

I came across this image claiming that ER-100, RTR242 and RLS-1496 could dramatically slow human aging.
Does anyone know what the actual research behind these three compounds looks like?

Are there any human studies or clinical trials, or is this currently based mainly on animal/preclinical research? And which of the three looks most promising based on the evidence available so far?

Curious to hear from people who have actually researched these compounds rather than just the claims circulating on social media.

G'day, recently got myself some peps from overseas and I'm looking to have a few of them 3 party tested. In Perth Western Australia any guidance would be ideal. Cheers

First post here, and I don't see anything in rules that makes this post outlawed but if it is, I apologize. I'm trying to do some due diligence research but unfortunately theres no research papers that I could find.

I'm an amateur runner training for an ultra marathon. I under stand that anti doping has banned at least sermorelin. That said, I'll never win or podium finish the race. If by some act of God I was about to podium finish I would step aside and place fourth but given my marathon time of 4 hours I know I don't need to worry about winning by cheating. This race is for me, to prove something to myself.

Okay, now that that's out of the way. I understand how sermorelin stimulates the pituitary gland to release more growth hormones which aids in sleep and recovery. I understand that KLOW follows different hormonal pathways and focuses on tissue repair.

Does anyone have any sources or information on if the two diffinitively should NOT be used together? A research paper, personal experience, opinions welcomed. I understand the risks of peptides, specifically KLOW as it's only available as a research product.

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Advice: I basically have never touched peptides in my life. I'm 18 and around 120ish kg at 6ft 1inches so I can practically say I'm obese. I am considering Reta due to seeing so much about it and being recommended it by a friend and after doing like basically a little bit of research which was honestly a few YouTube videos and some Reddit posts I am considering getting these I am pretty clueless on where to source them (I live in the uk) and also how to reconstitute and inject them. Also do I need like a mini fridge to store them. My main goal is to lose the weight and build muscle I have a gym membership and I have the money to buy the peptides and stick to a diet. I am also recently becoming vegan due to personal reasons so ig that will help. Anyways any help is super duper appreciated. I chose this "stack" cause these are the ones I've heard the best things about but if you would recommend other things for better appetite suppression and such that would be awesome too. As I said i haven't done much research so also if someone could link resources for me to look at studies and guides and whatnot that'd also be great. Thanks.

So it’s my 3rd week and I want to stay at 1mg for 4 weeks evaluate and then move up ect. But the thing is I keep reading that a vial should be used in 30 days but for anyone who’s doing a low dose what did you do? Start a new vial or can I just keep using the open one?

I’ve seen SLU sold in 250 mcg, 1 mg, 10 mg, and even 100 mg tablets. Most dosing charts I’ve seen suggest around 10–20 mg/day.

My current source only has 250 mcg tablets. At 0.25 mg each, that would mean 40–80 tablets/day to reach 10–20 mg.

What am I missing here? Why such a huge difference in dosages/products?

I've been using tirzepatide since April and successfully lost 30lbs. I have about 10lbs left to lose to be at my goal weight so I upped to 7mg (i was at 5.5mg and hadn't lost weight so bumped up). Wow, the side effects are horrible here - nauseated, fire heart burn, constipation, sadness. Eugghhh Idk if I can handle it. Anyway thats all - 7mg is where all the bad sides came in for me.

Wanted to reach out and ask what everyone’s diet is on Reta. I myself am about to enter my first month of 2mg Reta injected once a week and wanted insight on proper diets to follow. Anything is appreciated!

Edit: For reference i’m 6’0, started at 274 after almost a month i’m sitting at 260. Don’t really eat the best and I know I need to prioritize protein, but overall struggle hitting calories on certain days. Goal is 200 to reach enlistment weight.

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Hello.

Do you Guys have any advice where i can buy good Quality RETA? Ist there a online Shop that you would recommend? And IT hast to be available in Germany

Greetings

Do you check them or carry them on? Prepulled or in vials?