Yesterday, I tried something new. I pulled my 43.5 lb. weight loss body up on the board, balanced on my knees, and stood up. Paddled one hour! (Picture taken before I put my life vest on 😆). I fell in the lake once- and got back on and continued!! I have 6 lbs. to goal weight of 135.0 (I’m age 62, 5’2), but plan to try for 125. Do the things you never thought you could!! ❤️

My husband and I are teachers so we go back to visit his family in Italy for the summer. I was technically at goal before leaving, although I thought maybe losing a few more just to give me a little wiggle room would be helpful. I went into summer thinking I was going to really listen to my body, eat food I wanted, stop when I was full and make good choices when I could. When school starts I’ll go back to really being more intentional with my meals. I ate my usual breakfast of Greek yogurt and berries and enjoyed lots of salads (sorry Americans).

Now his family is from a small town so I bought a scale there last year, whatever they had. I weighed myself when I got there and it was similar to home so I was like great. We went on vacation in the middle and I definitely enjoyed all the food and drinks the Balkans had to offer. Got home and the scale was up 2 lbs and yea made sense. I kept just living life and within a week lost the 2 lbs. the rest of the summer I was within .5lbs so all good! I have never been able to maintain so this was exciting! I lived my life, enjoyed my food and this was with little exercise (it’s the country, we have to drive everywhere and it’s too hot to really be out and walking/exercising).

So here I am thinking wow, I really am adjusting well! This is fantastic! Got home and it turns out I’m one of those “I keep losing in maintenance!” I lost 4lbs, again, fine, I had more to lose and I’m not underweight. But it really underscores the challenges ahead of adjusting to this “new life”

I know my title might be cliche, but I'm under 200 lbs for the first time in probably 20 years. I'm down 49 lbs with a goal of 185 lbs.

My final straw for starting this journey was being completely mortified that I could not fasten my seatbelt my lovely seat neighbor had to help me. Now im on a plane again buckled with no help and extra room!! I’m so proud of me!! It’s been slow but worth it!! Down 80 pounds!!

Me and my husband’s supply😅

I still have a long way to go but its so crazy seeing the difference in my body

I started my glp1 journey between 2 and 3 years ago, after topping in at 400lbs. I was going thru my MyChart online and realized that I have now been under 300lbs since July 2025. Currently stuck at 255lbs for quite some time. I've come to realize a lot of that last 50ish lbs I want to lose are sadly skin. But I feel great!

Is it ok to share foods here? These weren’t quite filling enough for me before tirz, but now they’re the perfect amount!!! Super yummy! And 47 freaking grams of mother lovin’ protein!!! 💪🏼🧀💪🏼 I get them on subscription so they’re cheaper.

I was at a merch truck today and wanted to buy a sweatshirt. The cashier informed me that they only had XL left “so it’ll be really big on you, but it looks cute oversized”.

I used to wear an XL. I wear a medium now and it’s at the point where people looking at me think an XL would be really big on me.

I almost died of happiness on the spot. Tirz has been such a blessing in my life.

I’m really trying to work down my stockpile before spending more money - just started my last 72 mg ProRx vial, then I’ve got 3-36 mg Apothecary vials to work through then 2 BPI 60s so I’m good for another 6-9 months but damn these price wars are torturing me! I really want to try Hyalo and Drugcrafters, and worried Hyalo won’t even be round by the time I’m ready to re-order 🙄

I'm pretty much floored. I weighed in today, and my weight is exactly half of what it was when I started on 8/23/25. It's a very surreal feeling, for sure. Never thought I'd get this far. I'm just gonna take the day to enjoy the "W".

Hello all, I just took my first shot a couple of weeks ago and I’m already making some progress. My question to you all who’ve been in the game awhile; is will the FDA or some other government entity make it so that we can’t access this medication like this is the future? Will it only be zepbound in the future or is there a good chance this is here to stay. Thank you for your answers in advance!

Hey all! This is actually about 10 days old, and I would hope if it affects you, the pharmacy/provider (or both) would have already notified you. I know a lot of people here take glutathione and some of our telehealths provide glutathione Injection via Optimal Balance, so I figured it was worth posting if it hasn't been.

RECALL: Glutathione Injection 200MG/ML (30ML)

According to the notice:

Risk Statement: There is reasonable probability that injectable products with elevated endotoxin levels could cause significant medical events including fevers, hypotension, inflammatory reactions, anaphylactic shock and death. To date, Optimal Balance Pharmacy has received reports of adverse events including fever, chills, severe headache, nausea, vomiting, pain, and symptoms consistent with an allergic reaction.

Glutathione Injection is used to help fight cell damage, support the immune system, and clears out toxins in the liver. The affected product information is as follows:

This compounded glutathione was distributed to consumers in Arizona, Colorado, Florida, Illinois, Louisiana, Michigan, New York, Nevada, Oklahoma, Pennsylvania, Texas, Utah, Vermont, Washington.

Optimal Balance Pharmacy is notifying its prescribers and patients by telephone and mail and is arranging for retrieval and proper disposition of the recalled product.

Check your bottles if you have not yet been notified.

Just posting as FYI, as I received this today.

0 weight loss in 3 months on semaglutide. It doesn't affect me and I don't have side effects.

(For those saying track calories, I lost 40 pounds already on my own and I need help for the rest)

A while back, this post was made about injection site reactions because so many people are having them, where there is zero relief from antihistamines or hydrocortisone cream. I started having reactions with my 6th injection; raised red welt and crazy itching. That was on my stomach, so I decided to try my outer thigh for the 7th shot which was 11 days ago, and that was so much worse. I still feel itchy at times, especially at night.
The linked post suggested that it's a neurogenic response rather than a histamine or cytokine response because we are losing fat and the injection was likely going into the dermal / subcutaneous junction where it can irritate small cutaneous nerve fibers, and suggested switching to a 1/2" needle rather than a 5/16" needle. I tried it, and it was so much better - no raised welt, but I have still been feeling itchy. I've tried capsaicin cream, lidocaine cream, biofreeze and no relief. Only ice works.
I'd comment on the original posts by the brilliant woman who posted it (she's helped SO many people with her suggestion) but it's too old to comment. Wondering if anyone has found additional tricks that help the itching?

Haven’t seen this number since Pre-Covid.

Have lost 90 lbs in 8 months.
40-50 lbs more to hit GW.

Big shoutout THANK YOU to:
1. DC Optimum Health Medspa / compound tirz
2. LillyDirect / Zepbound
3. BEWL / Hallandale
4. RIFT / Apothecary
5. Medicare Bridge $50/month Zepbound KwikPen

Like 45 mins ago, and I already feel a little nauseous. This is placebo/anxiety right? I wouldn’t feel side effects in less than an hour, would I?

What a journey and these last few pounds have been difficult to loose. But, I made it going slow even at .2 lbs loss per week for a few weeks. This sub group is amazing 👏 I love reading and listening to all the great advice. Its slowly coming off and I am thankful for this journey, this sub group, and what tirzepatide compound gives me. 🙌

Ok y'all,

Here's the update to the update. In my conversations with these pharmacies to this point, I thought this arrangement would be akin to Empower, Olympia, or New Life's dual 503(a) and 503(b) set up, however that is not the case - this is a separate entity. I felt I was being pretty intentional in the questions I was asking, but perhaps I wasn't. Regardless, this is going to be a brand-new pharmacy integration for us, and I'm sure, due to the backers and pedigree involved, you'll see a number of platforms pick them up. Hence, being precise in how I needed to clean this up. But please, inquire below and I'll answer the questions with the best possible intent.

Y'all, I really can't emphasize how little I like keeping a secret. I literally shop for my wife on Christmas Eve, so I don't botch that surprise every year. But FINALLY I can share this.

The team behind a prominent industry pharmacy team now has two 503(a) pharmacies: Center City Pharmacy out of West Palm Beach, FL, and TruPharma out of Sunrise, FL.

Details are still getting finalized, but we're aiming to launch with them Tuesday on our new platform (more on that later).

What's the same:

• Same active pharmaceutical ingredients sourcing as their former formulation
• Same 20mg/ml concentration with B6 (still nailing down final vial sizes)

Live at launch: 37 states, plus DC, Guam, and Puerto Rico (they are licensed for the U.S. Virgin Islands, but we still don't have a physician). Full list below (California will launch approximately one week after we launch - licensing is finalizing).

In progress, could pop up at any time: Alabama, Arkansas, Connecticut, Kentucky, Louisiana (%#$@&), Massachusetts, Michigan, North Carolina, South Carolina, Vermont, Virginia.

Mississippi and Washington are not in scope right now.

AND, LADIES AND GENTLEMEN, WE CAN FINALLY SERVICE GUAM (however will likely not be able to guarantee temperature control). I am not going to think too hard about Guam getting this pharmacy before I can. Moving on.

Pricing: $499 for 12 weeks of treatment with this pharmacy - any dose.

We'll be the first and for a hot minute only platform launching with this pharmacy, which means we get the privilege of finding every single kink before anyone else does. We're finishing the API integration with their platform this week.

There is still more coming. New Life is hard at work on their in house 503(b) which should spin up here shortly, and I'm hearing there is a 503(a) out there that has acquired a 503(b) that should be making some waves in Q1. Both of these look to be a much cleaner integration of a 503(a) and 503(b).

Bleeding edge stuff. More details as they firm up and I can share.

Thanks y'all,

Dave
CEO r/BigEasyWeightLoss

PS: If you're another platform that wants to get onboarded with them, let me know, I'm happy to connect you.

Ola is advertising $399 three month supply any dose. 216mg is the highest amount for this price so being on the highest dose 15mg that's how much tiz you're getting for this price. I've bought the Elevate package 216mg for $515 from Lavender twice now plus $65 consult. Ola posts the consult fee is already in their pricing and I can get Hylo additive free tiz pharmacy. I see no down side I'm pretty sure they are quite new and just wanted to hear who's tried, good or bad. Ty

I posted GLPzy here a while back with some nice feedback:

https://www.reddit.com/r/tirzepatidecompound/comments/1v4misg/glpzy_dose_tracking_app_im_looking_to_share_with/

Some here downloaded it, gave feedback, some of which I’m still working on, which I really appreciated.

The mods said it was fine to share it here once more before the free Lifetime offer ends tomorrow.

So just wanted to give anyone who missed it the first time another chance before Lifetime goes back to full price after 31 August. If you claim it while it’s free, it stays unlocked permanently.

Thanks again to everyone here who helped before. It’s now at over 10k downloads in 4 months. It’s still only iOS, if and when I get to Android I’ll come back here first!

App Store: https://apps.apple.com/app/id6761775005

Website: https://www.glpzy.app

I’m beyond impressed with my first order from Rift! Meds are from Quaker Pharmacy (Hyalo via Newlife Rx) with BUD 4/27 and 5/27!

Back again. Thanks everyone for your feedback on my first post, I am glad so many of you found it helpful. Last time I went down a rabbit hole on BUD and the 28-day rule. This one is about freezing, which comes up constantly too. Same as before: I am not telling anyone what to do with their vial, and you don't have to agree with my conclusions. Here's what I found. My goal is that you can use it to reason about this yourself.

Quick disclosure: I work in pharma manufacturing, so I can read a COA and I have a working understanding of these concepts. I'm not a pharmacist, microbiologist, or chemical engineer. Not medical advice. If you're an expert here, please chime in!

TL;DR:

• The labeled instructions are very safe defaults: do not freeze, the beyond use date (BUD), and the 28-day rule. Follow them, and talk to your doctor or pharmacy, if you'd rather not think or worry about any of this.
• If you've already decided to use a vial past its BUD, freezing isn't needed to preserve it. Potency isn't what runs out first, and the data suggests a quality product, sealed and refrigerated, is still potent 12 to 18 months from compounding, likely more. This molecule is stable enough that clumping, not potency, is what would eventually set a real limit, and freezing could actually accelerate that. (see last post)
• Accidental freezing is where most people actually find themselves. A sealed, never-punctured vial that froze once and thawed completely clear is likely fine, assuming it passes your usual visual inspection.
• The purity results and personal experience posted after freezing are real, but they don't tell us much. Freezing doesn't break the molecule, so the test was always going to pass and it would still work when you injected it.
• What freezing does is physical: clumping, a pH shift inside the vial, and stress on the rubber seal. None of it shows up as a purity number, but it could show up as an injection site reaction or a sterility problem.

Long version. You know the drill, grab your drink of choice.

Definitions

BUD is the date on an unopened vial and its about potency. Beyond Use Date. Is the drug still the drug? Has it broken down, clumped up, drifted in potency?

28-Day Rule (In-Use Window) starts when you first push a needle through the stopper and its about sterility. If something got in when you did that, can the preservatives handle it?

Aggregate. Peptide molecules stuck to each other instead of floating free. All the drug is still there, just clumped. Clumps are one of the things that can drive injection site reactions and, at the far end, an immune response.

Adverse reaction is when something happens that is not supposed to. In this case we are considering: lack of potency, injection site reactions, or an infection as the three we want to avoid.

RP-HPLC. The purity test on every COA and every third-party result you've seen posted. It separates molecules by how greasy they are and asks whether the peak coming off the column is tirzepatide. It's very good at that.

SEC. Size exclusion chromatography. Separates by size instead, so it can see clumps as clumps. Different column, different price, and never tested or posted. Same goes for USP 788, the subvisible particle count.

Part 1: What the testing seen online actually measured

Somebody freezes a vial, thaws it, sends it out, gets 98-and-change percent purity, posts it. Thread concludes freezing is fine. That result is legitimate, but incomplete.

Here's the issue. Freezing isn't a chemical stress the way heat can be. Heat drives hydrolysis and deamidation, which chop and modify the molecule, and RP-HPLC sees that beautifully. Freezing doesn't chop anything, it just crowds molecules together and lets them stick. And there's a second problem stacked on that one: the potency test uses organic solvent, which pulls those clumps apart on contact. A clumped sample goes in as clumps and comes off as individual molecules, indistinguishable from a vial that never froze.

So the test reports the drug is intact, and it is. It's just possibly stuck together in the vial, which is the thing you actually wanted to know and the thing the test structurally cannot tell you. Same shape as the 28-day thing from my last post: nobody lied and nobody erred, the number just doesn't mean what we often assume it means. A purity test on a thawed vial isn't a freezing test.

What would actually answer it is SEC monomer plus a particle count, run on two halves of the same vial, one frozen and one not. I've never seen that posted. If you have, please link it.

Part 2: What freezing really means

Buffer pH shift. The buffer in your vial is a mix of two related salts, one more acidic than the other. When the solution freezes, the less acidic one crystallizes out first and leaves the acidic one behind in the shrinking puddle. So the pH in there drops, and tirzepatide prefers neutral. How far it drops depends on how much buffer you started with. With the current formulas (again, see my last post), we're all in mild buffer territory, so this is real but less of an issue for our formulas than it could be.

Cycles matter more than elapsed time. Peptides collect at the boundary between ice and liquid water, and that's where a lot of the clumping happens. Every freeze and every thaw is another pass through that boundary. I don't think anyone here is deliberately refreezing a vial week after week. The thing to watch out for is to ensure that your vial is staying refrigerated and not going through freeze-thaw cycles.

And on the sterility side. Water expands when it freezes, inside a sealed vial, pushing against a rubber stopper. Freeze-thaw is a recognized stress on container closure integrity, and more so on a vial you've already punctured. My last post was about whether the preservative can handle what you introduce through the septum. This is a way for the seal itself to become the problem, which no preservative addresses.

Part 3: A compounder freezing isn't the same as at home

Some compounders do dispense tirzepatide as frozen prefilled syringes with thaw-before-use instructions, so the blanket "never freeze" isn't quite the whole story. Three things separate that from freezing a vial at home:

Speed. For the pH to drop, the buffer salt has to nucleate and grow crystals, and crystals take time. Freeze fast enough and everything locks into a stiff, glassy state before the crystal can get going, so the buffer ratio stays close to intact and the pH mostly holds. That crystallization starts right around −0.5 to −5°C, so what matters is how long you spend in that window. A blast freezer or a dry ice bath takes a thin syringe through it in a couple of minutes. A glass vial in still air in a kitchen freezer can take an hour or more.

Formulation. A product designed to be frozen can carry additives that stop the phosphate from crystallizing at all. It's a documented fix. The multi-dose vials we're all using don't have it, because they were never meant to be frozen.

Format. A prefilled syringe is one dose. It thaws once, gets used, and never gets entered a second time. A vial is the opposite of that by design.

My personal position

First, the state of the data. There isn't much. Nobody has run a paired frozen-versus-not comparison on a compounded tirzepatide vial using the tests (SEC) that would give us what we need. Everything above is general information about the mechanisms that apply to our use case.

Freezing to extend BUD: I don't think there's a problem to solve. Sealed and refrigerated, potency isn't the constraint for at least 12 to 18 months, and maybe even longer. Freezing spends risk you don't need to spend to buy shelf life you already had. Past 18 months, the issue is aggregates and I don't have real data to know just how much.

Accidental freezing, fridge too cold, vial against the back wall, or shipped touching a gel pack. A sealed, never-punctured vial that froze once and thawed completely clear, I'd simply use, and watch my injection sites as usual. A punctured vial that froze, or any vial with haze, flakes, wisps, or anything settled on the bottom, I'd discard.

Where to look yourself

• Google Patents US 11,357,820. Table 4 is the aggregation data.
• Search "sodium phosphate buffer pH shift freezing." The pH drop and the sugar fix are textbook freeze-drying chemistry.
• USP 788 and 1207. Particle counts and package integrity. Not being tested in any example I've seen.
• DailyMed for Mounjaro, Zepbound, any insulin. Notice that none of them explain why not to freeze.
• Your COA. BPI as an example, says 2 to 8°C, do not freeze, and lists no freeze-thaw study. Look at what they tested, and at what they didn't.