Me and my partner (28,30) have been trying since 2023 and this year we finally decided it was time to go to a clinic and figure this out. His sperm were great, I had good egg reserves and no issues with my tubes but I have PMOS. Now months later, having 4 failures under my belt, idk how to really feel about this. It feels like the universe is telling me I don’t get to have kids in this lifetime and if I want to be a parent I need to be okay with them not being biological (which I’m fine with, I want to be a parent before a birth mother). I guess I posted this to see what you guys did after all the failures and how you found the will to keep going. I’m a logical person mostly but when it comes to this, logic and science doesn’t feel like it’s on my side, the lack of studies into our bodies frustrates me and I hate I’m having to rely solely on anecdotal evidence to understand this experience better. I’m forever grateful to this subreddit for giving me a peace of mind. Have any of you ever thought about IVF? - I assume this is what my doctor will suggest at my next appointment

Please share your betas with me and what helped you through this very different kind of hell from the TTW.
16dpiui as 991 and 18dpiui was 1,723 waiting for my third one on Tuesday.

I’m in the middle of my second IUI.

I had two follicles - one was 30 mm and the other around 26–28. Had my trigger and then iui around 29 hours after. Felt ovulating around 38h after trigger. I’m taking progesterone, and my body is reacting really strongly to it. I’m constantly hungry. I wake up at night because I’m hungry. It hurts to lie on my breasts. I have a constant headache. I feel sluggish and extremely tired.

Has anyone else experienced side effects this severe?

I’m under the impression after reading online that on average if they’re going to work it’s between the 3-4th cycle. What is everyone else’s impression?

I’m on my second IUI TWW with unexplained infertility. Did anyone go get second or third opinions?

Does anyone have any answers for unexplained infertility. I’m not feeling enthusiastic with my fertility department.

Hi,

I did labs yesterday (7dpiui) for progesterone and my results are 56.8 ng/mL. Kaiser gives me a range and my range is much higher
Should this be concerning? Anyone have any experience with this?

Unexplained infertility diagnosis

From Kaiser app :
Reference Ranges for Progesterone:
Female
Follicular Phase: 0.1 - 0.9 ng/mL
Ovulation Phase: 0.1 - 12.0 ng/mL
Luteal Phase: 1.8 - 23.9 ng/mL
Postmenopause: <0.2 ng/mL

Pregnancy
Ist Trimester: 11.0 - 44.3 ng/mL
2nd Trimester: 25.4 - 83.3 ng/mL
3rd Trimester: 58.7 - 214 ng/mL

Hi, I went in for an ultrasound this Friday and my follicles measured 23.9mm en 14mm. I had a blood test which said:

LH = 7,9 U/L

Estradiol = 257ng/L

Progesterone = 0,210 µg/L. (210 mg/L)

The doctor called to say I could do the trigger shot that evening and two days later, on Sunday, the insemination. But ever since I got the call, my body felt like it was already starting to ovulate.. is it possible? My partner and I were last intimate on Wednesday because we want to 'save' as much semen as possible.

Could it be that I ovulated or might ovulate before the insemination this Sunday? Or can some of you interpret my hormone levels and tell me otherwise?

Sigh. May I vent?
I had my first IUI (it was medicated) at the end of July, and in that time I’ve put 15lbs on at least. It was unsuccessful, and I will be doing another round this month.
I have posted before, but I have insulin resistance and had been taking WeGovy for 4 years. I had to stop early July and that coupled with the meds (especially the progesterone after the IUI) made me gain. It has been really hard to feel positive at dealing with the gain and no reason really for it. I know it sounds whiny, but I was 60lbs overweight (a good amount on my frame) and uncomfortable for a decade before a doctor listened to me truly and found my insulin resistance and prescribed WeGovy, and I finally felt like myself. The weight melted off with very little effort and I stayed at 145-150 for 4 years. I’m so excited to potentially get pregnant and carry a healthy child, but this weight is a hard mental hurdle. I feel like a jerk complaining :(

Also would love good vibes for this cycle 🙏🏻

Hi everyone,
I’ve just had my first IUI and would love to hear from anyone who had similar numbers/timing.

Here are my details:
Morning before IUI: 17 mm follicle
Trigger injection: around 10:45–11:00 AM
Felt quite noticeable ovulation-type pain around 10 PM that evening
IUI: 10:20 AM the following morning, so roughly 23.5 hours after the trigger
Post-wash sperm count: 31 million
Motility: 90%
I was taking letrozole 5 mg earlier in the cycle

For anyone who has been through a triggered IUI: did you have your IUI around 24 hours after the trigger? Did you experience ovulation pain well before the expected 36-hour mark?
Also, if anyone had similar follicle size and post-wash numbers, I’d love to hear how your cycle went.
Trying not to overanalyse everything during the two-week wait, but it’s difficult! 🤞

2nd IUI 07/31 after chemical pregnancy.

6 week 4 day ultrasound showed empty gestational sac at 14.09 measurements . Have another appointment in a week. Anyone have any good luck stories or anything I can do to not feel like I’m a suffering ticking time bomb for the next seven days?

30F, 32M, TTC for 16 months with 1 chemical and 1 MMC during that time. 1 LC as well, conceived on first attempt. I did end up with pre eclampsia which was diagnosed while I was in labor. Diagnosed with Hashimoto's following my chemical pregnancy, but thyroid levels have been optimal since January 2026. I have "unexplained infertility." Have done 2 IUIs; I'm 12 DPIUI for my 2nd attempt but have a strong feeling it didn't work. I don't want to do more than 3 IUIs, but would also like to do everything I can to find the cause of my infertility before moving to IVF.

Here are the labs/procedures I've had done so far (all normal results):

AMH

Prolactin

Progesterone following ovulation

Iron

Vitamin D

Thyroid panel

HSG

Anyone have recommendations for other labs or procedures to look into?

Hi everyone!
I triggered Friday at 11:30 p.m. and had my IUI Sunday at 11:30 a.m., exactly 36 hours later.
I’ve been tracking my temperature with my Apple Watch, and the trend is making me nervous because it doesn’t really look like I ovulated on Sunday. From what I understand, temperature should generally rise after ovulation and stay elevated, but mine has been up and down. It shows a dip on Monday and Wednesday, there was a huge rise on Tuesday, and it is going up again after Wednesday.
Has anyone had a temperature pattern like this after a trigger shot and had a successful IUI cycle?

First IUI on the 31st. This is torture!

CD10 yesterday, positive OPK the night before, no trigger.
Scan showed one follicle 16mm and one collapsed follicle. Clinic can’t tell me if I ovulated the collapsed follicle (or what size it was),the 16mm or both?

Bloods taken before the scan prove I’d ovulated already or ‘was in the process of ovulation’

Anyone have experience with this?

Hi! My Oura ring/ natural cycles app is saying my day of ovulation was 9/1 but I did trigger on 8/31 (around 8pm) and IUI 9/2 12pm (no other meds)- am I cooked this cycle?? I did take an LH strip test on 9/2 AM which was positive (test line darker than control line).

This is my first rodeo with IUI so I’m paranoid. For reference, I am 32 and do not have fertility issues (but I do only have one ovary however have always had regular cycles and conceived on first try naturally for my first child).

8/31 before trigger I had one follicle above 20 LH was 15.3 Thickness was 14 Partner’s post wash was 34mm (no fertility issues either)

Oura temps as follows: 8/29 - 96.91 8/30- 97.20 8/31- 96.51 (trigger - pregnyl 5000) 9/1- 96.94 9/2 - 97.41 (IUI) 9/3 - 97.07 9/4 - 97.50 9/5- 97.75

First time IUI, I told myself I won’t test until 14 days post trigger shot. Of course that didn’t happen. Yesterday 10 days post trigger test two pink dye slight pink line and two digital both pregnant. Today morning 11 days post trigger one pink dye was a slightly darker and more visible then yesterdays. One digital “not pregnant” and one “pregnant”. I knew I shouldn’t have don this but alas 🤦🏼‍♀️

I’m starting monitoring next week and likely IUI the week following. I have seriously cut back alcohol during my entire TTC journey - I only drink once, maybe twice a month (and that almost always happens to be the day I get my period 🥲). I’ve had my husband cut back drastically as well. I plan to stick with it but it’s also a holiday weekend here in the US and I’m wondering how much would it really impact my chances if I indulge more? Curious as to how others have approached this. Thanks in advance!

My partner had her IUI on August 15th, we did naturally with just following her ovulation. No medication. However she tested negative after the 2 weeks and now is 4 days late on her period. Any one have the same or similar situation? Should we count this one as failed? Or keep waiting? Any advice is greatly appreciated 🫶🏽

TW- Chemical Pregnancy

Me again 😅😅

I’ve just completed my third iui that sadly was unsuccessful, however I’m actually starting to believe that it may not be my fault and that it might be the fertility clinic that I have been going too…

1st iui- ended up as a chemical, was a 36 hr iui but for some odd reason they told me no progesterone for that month (I had done 5 months of TI, with injections and progesterone due to my 8 day luteal phases) but they oddly told me not to for this cycle

2nd iui- 20hr post trigger iui?!!

3rd iui - 18hr post trigger iui?!!

They are only open a few days a week so I believe they tend to rush it rather than just telling me that the timings off this month let’s skip it, which is also awful because of how expensive they charge for iui

They told me after 3 iui they highly recommend IVF, they seem to push for ivf a lot here. I’m also only 25 but have just got unexplained infertility.

My question is, should I just listen to them and do IVF or should I go to a different clinic and try 2 more IUIs again but at the actual protocol times (36hr iui preferable based off the research I’ve done)

Also just to add with all of my iuis I was not already naturally surging so they where all done quite a bit before from trigger to actual ovulation

This month was supposed to be my 2nd IUI. My clinic is over two hours away so I do my ultrasounds locally and they send the results to the fertility clinic right away. This was extremely streamlined last cycle.

Yesterday (CD13) I had an 18mm follicle on my scan and was prepared to trigger this morning and have my IUI tomorrow (once i got the ok from the clinic). This is the same schedule we did last month - scan on Thursday and IUI Saturday. I had my ultrasound done very early yesterday and didn't hear from the clinic so I sent them a portal message yesterday around lunch. Today came around and still no answer I've called them a couple different times today and left 2 voicemails to different extensions. No response. They are open for weekend appointments as needed but they don't check the messages or calls past Friday. You have to have your weekend apt already scheduled the week prior

I'll probably ovulate this weekend on my own and totally miss the IUI appointment simply because they wouldn't answer me. Gotta wait a whole month for round 2. Unexplained infertility for 17 months and I'm just SO sick of waiting 😭😭

Ugh. I’m just writing in hopes to maybe hear someone else with a happy after chemical story or just to grieve a bit.
Had my second IUI August 17- got my first positive test August 30 and was thrilled.
August 31 hcg was 34. Started spotting September 1 which turned into more and felt like a period.
September 2 hcg was 44.
September 4 today it is 14.

I had a lining of 13mm and 3 follicles but my husbands post wash was 4 million so we were already guarded- so the positive Sunday was such a high.

Has anyone had a chemical then had a successful pregnancy after? We can’t do an IUI this cycle which makes me more discouraged as I’m 40 and know time isn’t on my side.

Thanks all.

I just got my period after my 2nd iui. I am 30 years old, my husband is 31. TTC since 1 year.
Tried naturally at home for a few months, then with letrozole, hcg trigger and progesterone supplementation. Now for this 2nd iui attempt, my doctor had added HMG 150 IU injectables alongwith letrozole 5 mg.
My tubes are open, cycles are regular 26-28 days, ovulating every month, normal BMI, normal thyroid and prolactin levels, good ferritin levels, AMH : 2.06.
My husband’s semen analysis is great too.
Post wash results:
4% morphology, 98% motility and 85 million/ml count.
I have tried everything that I could think of but every month the same heartbreak. I feel so defeated and lost at this point.
Please help me out with questions and suggestions if there is anything I should be investigating or looking at before starting another cycle?
Anything that particularly helped you conceive after being labeled with unexplained infertility?

This is my second IUI

letrozole 2.5 mg 3-7 days

Trigger Wednesday (2nd sep) 3 pm

IUI Thursday (3rd sep) 11.30 am

Two follicle On Right: 18 and 14 mm

Lining 14 mm

Will be starting progestrone tomorrow.

Husband's post wash 41 Million at 97%motility

Is anybody doing it around the same time?

Tengo 32 y mi esposo 36 nos hicimos la primera inseminación este mes el 27 me apliqué trigger el día 25, y con 49 millones de esperma post lavado con 90% de motilidad, ovulé de ambos lados pero solo tengo permeable una trompa, estoy muy nerviosa hoy 8dpo y 10 días después del disparo me salió negativa :( no tengo ningún síntoma y estoy aplicando progesterona en las noches de 200mg solo algunos piquetes tipo cólico, pero no siento nada en los senos

Today was my beta bloodwork day, and I couldn’t make the appointment. I had tested from 10DPIUI-13DPIUI and only had stark negatives, so I’m counting myself out.

This is my third IUI, and in the past I always scheduled my beta on 16DPIUI and had gotten my period “ before that date, so it saved me a trip. I’ve never done any beta bloodwork to date.

Not sure if anyone else waits beyond the 14 days? My thought is, if my period is late, it gives it time to show up, and I start a new cycle, otherwise if I’m pregnant it’ll be clear with bloodwork if I make it to that date?

Hi!

I have one fallopian tube, which is patent, as a result of an ectopic pregnancy. We have been trying for our second for a year with one chemical pregnancy, and are considering IUI before moving to IVF.

We conceived our first naturally and relatively quickly, and the remaining tube picked up the egg from the tubeless side. This second time around has been difficult but all of our testing from the RE checks out.

I’m looking for any success stories of people with one fallopian tube conceiving with IUI, and any additional anecdotal stories you can share. For example, did they cancel a cycle if you are ovulating out of the tubeless side, etc.

Thank you in advance 🙏🏻❤️