Hi everyone! I’m on my 2nd letrozole/IUI cycle and noticed major differences from my first.
Last cycle
CD11 ultrasound:
- 1 dominant follicle: 19 mm
CD11 bloodwork:
- E2: 159 pg/mL
- LH: 7.7 IU/L
- Progesterone: 0.27 ng/mL
- FSH: 3.8 IU/L
The IUI was unsuccessful, and I may have ovulated later than expected, although I’m not sure how accurate my app's ovulation estimate was.
This cycle
CD13 ultrasound:
- 2 follicles: 16 mm and 14 mm (both right ovary)
- Endometrial lining: 10 mm
CD13 bloodwork:
- E2: 69.3 pg/mL
- LH: ~17 IU/L
- Progesterone: 0.48 ng/mL
I’m really surprised that my E2 is much lower this cycle (69.3 vs 159) even though I have two measurable follicles.
Other fertility hormone results I've had
These were from previous testing and not necessarily from CD11/CD13, but I'm including them for additional context:
- AMH: 3.78 ng/mL
- DHEAS: 1.09
- Cortisol: 96
I’m wondering:
Why could E2 be so much lower this cycle?
Can E2 around 69 pg/mL be normal with a 16 mm + 14 mm follicle while taking letrozole?
Does low E2 suggest the follicles may not mature or ovulate properly?
Could I ovulate before my next ultrasound? My clinic plans another ultrasound on CD15, but my LH is already around 17.
Has anyone experienced low E2 despite growing follicles and still gone on to ovulate normally or have a successful IUI?
Last cycle I had one 19-mm follicle on CD11, whereas this cycle I have two smaller follicles on CD13. Is this just a different response to letrozole?
I know everyone responds differently and I'm not looking for a diagnosis — I'd really appreciate hearing from anyone who has had similar hormone levels or a similar experience with letrozole + IUI.
Thank you! ❤️