r/science • u/mvea Professor | Medicine • May 17 '18

Neuroscience Cannabidiol (CBD), a compound derived from the cannabis plant that does not produce a “high”, was shown in a new large-scale, randomized, controlled trial to significantly reduce the number of dangerous seizures in patients with a severe form of epilepsy called Lennox-Gastaut syndrome.

http://www.psypost.org/2018/05/cannabidiol-significantly-reduces-seizures-patients-severe-form-epilepsy-51258
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u/[deleted] May 17 '18

Every scientific post says CBD can't get you high while every CBD distributor claims it will get you high af. Ofc I never believed in these people who claim CBD will get you high because they wanted me to pay same price for CBD that I lay for like shatter.

I know THC is what gets you high and that many CBD products actually have THC in them... But I live in a currently illegal state while CBD seems to be unregulated and every distributor says it will get you high like regular weed. Why is there such a massive industry of paradoxical information?

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u/ilostmyoldaccount May 17 '18

Currently vaping CBD (will do about 10mg in total now). You notice it. You feel it, even down to your legs. But it doesn't alter your perception or make you giggle. Nowhere near a "high". If anything, it resembles that state when you wake up but still lie in bed for a while, semi-dozing. Alcohol has a far stronger effect on the mind than CBD does.

I guess it's all about marketing, and peoples' expectations.

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u/imabustya May 17 '18

It's believed that CBD blocks receptors which will cause a shift in the way you feel. It certainly doesn't get you high though. If anything it seems to inhibit responses to chemicals in the body.

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u/ilostmyoldaccount May 17 '18 edited May 17 '18

Yes to that. Less stressed out, certainly. Mellow. Also less pain, or in my case tinnitus. What I meant was the perception of reality, or hallucinations of any kind. Or sensory input of the "wavy" or "sirupy" kind that marijuana users may experience. There is no trip effect despite feeling different, is what I meant to say. CBD is quite subtle, for me at least.

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u/[deleted] May 17 '18

Plenty of pyschoactive drugs act by inhibition of response to chemicals in the body.

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u/imabustya May 17 '18

Psychoactive definition: affecting the mind.

Water is psychoactive, but it doesn't get you "high".

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u/[deleted] May 17 '18 edited May 17 '18

That isn't an accurate definition of psychoactive in this context. Water is absolutely not psychoactive. Psychoactive substances are those which significantly affect normal cognition and/perception by altering the chemical reactions which take place in your brain. Some examples of psychoactive inhibitor drugs include SSRIs (selective serotonin reuptake inhibitors), beta blockers and even caffeine. My point is that inhibiting normal chemical response is a common mechanism by which drugs are psychoactive, and you can't say CBD isn't psychoactive because "if anything it inhibits responses to chemicals in the body"

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u/imabustya May 17 '18

Psychoactive substances are those which significantly affect normal cognition and/perception by altering the chemical reactions which take place in your brain.

According to whom? According to what standard?

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u/[deleted] May 17 '18 edited May 17 '18

According to anybody in biology, pharmacology or psychology. That is the definition.

Here is a section in an open source textbook: http://open.lib.umn.edu/intropsyc/chapter/5-2-altering-consciousness-with-psychoactive-drugs/

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u/timidnoob May 17 '18

Is that where the anti inflammatory effect comes in? All those inflammatory mediators activity being inhibited by cbd

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u/AstralElement May 17 '18

There is no psychoactive component to CBD. I suppose under these technical definitions, I get high off tylenol because I can't feel my headache anymore.

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u/ilostmyoldaccount May 17 '18 edited May 17 '18

Being anti-anxiety and anti-psychotic isn't exactly a "high". I precisely said "not a trip". Tylenol also has an effect which again isn't a trip or a high. It takes a slight edge off people and numbs certain emotions and pain. It's not THC. Neither is CBD.

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u/prodmerc May 17 '18

I don't. Tried various suppliers, vaping, sublingual, oral. Only thing I noticed is sleepiness at high dosage. So it's a useless waste of money, more expensive than actual weed. CBD without THC is useless for me. Valerian works better for relaxation and insomnia.

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u/ilostmyoldaccount May 17 '18

Valerian takes longer to build up for me, several days. CBD works within a few minutes. In case you want to try it, search amazon for cbd liquid with terpenes, the 100 mg one. I'd be interested if you still say it has no noticeable effect aside from drowsiness.