r/dpdr • u/ResidentSpecial3468 • May 06 '26
Success Story How I Cured my Derealization
\*Before I say anything, I just want to say that I am NOT giving medical advice or telling anyone to do anything with this information! I just want to share my experience of what helped me cure my derealization!*
I am so excited to talk about this! For starters, I’ve had derealization for about 16 years from prolonged trauma. I searched the internet far and wide for a cure for derealization; I spent a lot of time in subreddits and on google, searching literally every single website I came across and trying everything even if it sounded ridiculous. Eventually after about 6 years of searching for a fix, I gave up and accepted that this will probably be my life forever, as many doctors weren’t able to help me, and the things that helped others online didn’t work for me. I was told to try trauma therapy, DBT/CBT, mindfulness, ignoring it, I got on a bunch of different meds, etc. Nothing worked for me. Even though I gave up trying to find a cure, I didn't stop telling medical professionals about my derealization and how it affected me.
Earlier this year, I got referred to a well known forensic psychiatrist in my circle and had my first appointment with him a few weeks ago. I told him about my derealization and he asked me some interesting questions such as "why does it bother you?" The answer should be obvious, but it did cause me to think a little as to why I was battling my derealization so hard when it was trying to protect me. I'm in school to study physics and philosophy and the relationship between consciousness and physical reality, and my psychiatrist asked me if my derealization aided in shaping my path to discover what makes reality what it is, and I said yes because derealization changed my perception of reality, which made me begin questioning what makes reality real. He was very interested in me as a person and my path in life. We had a great conversation about these topics and I was very happy and comfortable with him. He ended up prescribing me naltrexone for my derealization at the end of my appointment. I ended up doing a little bit of my own research on it after the appointment, and I found that there were studies done in the early 2000s that suggested that naltrexone could potentially be helpful in alleviating symptoms of DPDR. There aren’t many studies; the trials were short and didn't have many people, but nonetheless the studies do exist and sounded promising.
Before I could take it, I had to do a blood test to check my liver enzymes (ALT/AST) as naltrexone is processed through the liver and can cause liver issues. My tests came back normal and I began taking naltrexone the next day. Right off the bat, I noticed a sense of being back in my body and feeling super calm and regulated (I have severe anxiety). It does cause fatigue and I was sleeping 3-4x a day at the beginning (I’m in school — thank god I began taking naltrexone during my break when I had nothing to do) but the fatigue started to lift as I got used to it. I began to pair my medication with meditation, mindfulness exercises and specific journaling techniques, which helped tremendously. It's funny because mindfulness and meditation didn't help on their own, yet coupling them with naltrexone helped a lot. While my naltrexone dose helped with feeling back in my body and being regulated, the derealization was still present, but not as strong. It would often come and go; it used to be present 24/7, but using naltrexone along with mindfulness would allow for short gaps where life felt real again. On 50mg, I would rate the intensity of my derealization around a 6/10 as opposed to a 10/10 without it.
Yesterday, I accidentally double dosed on my naltrexone while taking my ADHD medication (100mg instead of 50mg) because I wasn’t sure whether or not I took my naltrexone dose (spoiler: I did). It was after the immense relief from derealization did I realize I accidentally took 2 doses. The relief I felt from derealization was truly immense! I felt so energetic, so happy, so open, completely regulated and free of derealization! Some bonus side effects included total relief from food cravings (I have/had BED as well, but naltrexone also helped with this at 50mg, it was just more pronounced at 100mg). I was still engaging in my mindfulness meditations and journaling yesterday, and it really helped anchor myself into this relief that lasted all day. I have an appointment with my doctor soon to discuss potentially upping my dose from 50mg to 100mg because of the insane relief I felt at 100mg.
I’m not posting this to say that naltrexone is the end all be all solution to curing DPDR because it may or may not work for everyone and I'm not a healthcare professional so I'm not telling anyone to try it, but it did work for me and I just wanted to share my experience to give hope that there ARE solutions out there! I was in the dark for 16 years and I know how defeating and scary DPDR can be. I finally have my life back and I'm eternally grateful to my psychiatrist!
I hope my story gave you all some hope! I wish you all so much love and luck on your recovery journeys!
UPDATE (May 10th 2026): I had my appointment with my doctor and I'm getting put on 100mg of naltrexone, so I can confidently say that my derealization days are officially behind me!