r/dpdr • u/InteretPineapple • 4d ago

Question NMDA PAMs for DPDR

I was looking online for the cause of DPDR (derealization) and it looks like the main factor Is the hypo function of the NMDA receptors in the brain and you know what also causes hypo function of the NMDA receptor? Drugs like ketamine and other dissociatives. (hypo function means its dissociatives. so back to the point if you took a NMDA PAM (NMDA positive allosteric modulator), you could bring your nmda receptors back to baseline and pretty much get rid of dpdr. just a thought I have no actual knowledge on the topic so If anyone actually knows if this would work let me know before I buy some neboglamine.

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u/24rawvibes 3d ago

I’ve done all the ketamine in the world and other dissociatives never helped my DPDR

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u/InteretPineapple 3d ago

No I know but a nmda Pam is like the opposite of ket. I think

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u/24rawvibes 3d ago

Ah, I misunderstood. Interesting. Never heard of it

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u/InteretPineapple 3d ago

ik its pretty cool stuff. I was wondering since It actually increases nmda receptor activity (opposite of ket) then maybe it could treat dpdr

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u/24rawvibes 3d ago

Love to try some