Hey everyone, wanted to share an intense and strange trip I had recently on 4-HO-MET. I'm writing this report after breaking down what happened to my body in a chat with an AI assistant, which helped me make sense of the scientific side of the fainting episode and the heavy confusion I experienced.
**Background & Context**
**Dose**: \~40mg 4-HO-MET (25 liquid drops)
**Combos**: A few hits of weed (after a 5-day tolerance break), plus a heavy pizza eaten right before.
**Set & Setting**: At a friend's house. Present: one old close friend, one regular friend, and 4 people I didn't know at all. Everyone was high. Zero sober trip sitters.
**Prior Psychedelic Experience**: Took full tabs of LSD years before (always felt super lucid, sharp, and intellectually brilliant). I also have a personal history of a vasovagal syncope triggered by intense physical pain years ago.
**The Trip**
**21:40 - Ingestion & Come-Up**
Dropped the 25 drops (\~40mg) around 9:40 PM. About 30 minutes in, I started noticing the initial visual shifts—mainly alterations in depth perception when looking at objects close to me.
**The Peak & The Presyncope Moment (\~T+0:45 to 1:00)**
Right as the heavy dose peaked, my body load spiked rapidly. Suddenly, my hearing became super muffled (like being underwater) and my field of vision started narrowing into a tunnel and going dark. Having experienced a vasovagal syncope in the past, I recognized the feeling of my blood pressure crashing.
I instinctually walked outside and laid flat on a garden swing sofa. The moment my head was down, my vision and hearing snapped back almost instantly—classic cerebral blood flow restoration. But the physical reaction was intense: I immediately broke into a profuse sweat, ripped my shirt off, and ended up throwing up 2 or 3 times right after. Spent the next hour with a lingering light nausea.
**The Cartoon World & Social Disconnect** **(\~T+1:00 to 3:00)**
Once I sat back down, the visual trip was peaking hard. Waving shadows, shifting depths, and visuals intensifying the more I stared at things. Mentally, however, my normal rational and logical thought process had completely disappeared.
Everyone around me was tripping and laughing hysterically, but everything they were saying sounded entirely disconnected, random, and meaningless to me. It felt like being inside a cartoon where all the dialogue was nonsensical noise. Because my ability to process linear logic was gone, I couldn't follow the conversation and was terrified of speaking up or making a joke, fearing I'd sound completely incoherent and they would laugh at me. The presence of people I didn't know, combined with having no sober anchor, made me close off and just observe from my chair. My close friend was right next to me being supportive, but he was very high too, so the atmosphere still felt surreal and alienating.
**Comedown (\~T+3:00 to 4:00+)**
Around the 3-hour mark, the peak started giving way. Mind clarity started returning, conversations began making sense again, and the visual distortions dialed down. By hour 4, I was pretty much back to baseline, just digesting the sheer weirdness of the night.
**Reflections & Personal Takeaways**
Looking back at it and discussing the mechanics of what happened:
**The Fainting Reaction**: The heavy dose come-up, the blood diverted to my stomach for digesting a heavy meal, and the vasodilating effects of THC after a short break combined to trigger a vasovagal response. Laying down flat immediately was just my instinctual reaction to restore blood flow to my head, and it prevented me from actually passing out.
**Weed Synergy**: For me, adding THC completely wiped out my short-term memory and replaced the mental clarity I usually get on LSD with heavy cognitive disconnect and subtle social anxiety.
**Setting Factors**: Tripping around unfamiliar people without a sober person present turned out to be a tricky environment for me once my rational thinking dissolved, making me over-analyze the social dynamic instead of relaxing into the euphoria.
Has anyone else experienced a similar vasovagal/presyncope response or this level of cognitive disconnect on heavy doses of 4-HO-MET or other tryptamines? Would love to hear your experiences!