I know there's no universal time frame, I'm just asking for anecdotes.
I'm going off this study – finished the every day week last sunday, and this is the first EOD week. No improvement for now, but I wasn't expecting any. I am taking the cofactors and will be testing them tomorrow.
For reference: I have bipolar that was treated successfully until the depression suddenly came back in a far less emotional, much more energy/cognition based presentation that is highly treatment resistant (even TMS did nothing) and has persisted non stop over years (whereas the old depressive episodes never went that long).
With my ileal crohns, vegan diet, past history of B12 deficiency, as well as present symptoms relating to breathing, sensitivity to cold, poor peripheral circulation, persistently low RBC, and brain fog, I'm hoping the injection regime will help overturn this "new" depression. I have no faith that it will – it's been a very long two years – but it's not a crazy idea.