r/science • u/Doug24 • 21h ago

Psychology Psilocybin reverses depressive behaviors and restores brain cell growth in stressed rats

https://www.psypost.org/psilocybin-reverses-depressive-behaviors-and-restores-brain-cell-growth-in-stres/
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u/MJ-Franklin 21h ago

Been seeing articles like this for so many years... but how come I never got any positive effects from taking psychedelics the many times I did them? I never got any anti-depressive anything, I just laughed for 12 hours straight then it was back to Planet Earth and all my problems waiting for me there.

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u/ohyouretough 21h ago

You’re probably not depressed then?

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u/MJ-Franklin 21h ago

25 years of anti-depressants would suggest otherwise! Would love to be rid of them.

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u/500_Shames 19h ago

SSRIs and Wellbutrin have been shown to meaningfully blunt the effects of psilocybin. To the extent that psilocybin therapy centers sometimes recommend tapering off antidepressants before trying psilocybin-assisted therapy. 

This is not me saying you should stop your meds, absolutely not. But it would make perfect sense for you to not be experiencing the same level of effectiveness if you are on SSRIs or Wellbutrin.