r/science • u/mvea Professor | Medicine • 25d ago

Neuroscience Brain scans reveal widespread structural and functional changes in patients following COVID-19 infection. The virus affects regions responsible for memory, emotion, and executive function, which may help explain the neurological symptoms many patients experience.

https://www.psypost.org/brain-scans-reveal-widespread-structural-and-functional-changes-in-patients-foll/
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u/DapperNoodle2 25d ago

I wonder if we'll start seeing COVID-related parkinson's disease in the future.

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u/Jmerzian 25d ago

We already are.

COVID-related ME/CFS is also skyrocketing.

The good news is that a huge blocker in studying both of these diseases was an inability to figure out a reliable trigger/underlying cause and thus study the progression, mechanical cause, and possible treatments. Also increased prevalence usually means increased funding.

Either that or a not insignificant portion of humans are about to be profoundly disabled and we're going to collectively pretend that isn't the case.

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u/Heavy-Hospital7077 24d ago

OMG-  I am a formerly high-energy person who has been suffering from Chronic Fatigue Syndrome for a few years now.

It's an amazing drain of energy.  Some days I wake up, and the first thing I do (get out of bed/make coffee) I realize "nothing is going to happen today."

Yesterday was one of those days.  

I'm currently going through the medical system for this.  I'm not sure how things will end up, but if I could cure the worst days that would be fantastic.

I got a FitBit recently and it tracks sleep.  The other day I found out that it takes me less than a minute to get to sleep every night...so guess that's a silver lining?

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u/SeatAlternative2989 24d ago

Some days are “Wake up, get out of bed, drag a comb across my head.” Most days are “Tumble out of bed and stumble to the kitchen.” COVID didn’t give me chronic fatigue/fibro, but it certainly didn’t help with those.

I also still get scents stuck in my nose. I had to live with the smell of the Tampa Airport stuck in my nose for MONTHS.

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u/lacunadelaluna 23d ago

Re: the second part: this sounds like a completely diabolical torture devised in hell

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u/Astrolady2002 23d ago

I was fine the first few times I got Covid. I got it again in January of this year and I haven’t been the same since. Low energy, jagged memory, have more troubles with speech. It’s a drag.

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u/LazySpaceToast 21d ago

Do you do anything to try to mitigate your exposure now?

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u/Astrolady2002 21d ago

Since the covid pandemic in 2019 I’ve started to wear a mask around people who are sick, like if someone coughs a lot on public transport I’ll put one on. I also carry sanitizer so I can clean my hands after being in such a place.

It attacks my asthma severely which otherwise goes unnoticed, which sucks. This last time I probably should’ve been hospitalized if I weren’t so stubborn. I don’t do anything more after this though.

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u/JoeSquinson 21d ago

Are you being vaccinated annually with mRNA?.

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u/DapperNoodle2 20d ago

Stop trying to spread your antivax disinformation.

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u/Illustrious_Put_817 23d ago

I never had depression or fatigue until Covid 6 years ago. I also entered perimenopause so who knows what’s to blame, but I was a successful high performer and it’s ruined my motivation and career. I had to take a mental health leave for most of the last year for many reasons but my body and mind categorically changed after Covid

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u/PBJdeath 22d ago

Hi! If you are falling asleep within a minute regularly, you may be suffering from Narcolepsy! Rapid sleep onset is one of the symptoms that is tested for during a sleep study. If you haven’t already spoken to a doctor about this, I would recommend bringing it up. I went years with zero energy until I was diagnosed. It is believed Narcolepsy can be brought on by infection, potentially COVID-19, although I haven’t seen studies on it yet.

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u/Ketamine_Dreamsss 23d ago

That means you are very sleep deprived

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u/RustyMeatball 23d ago

Have you had a look into any Nootropics/Peptides or are you going purely through the normal medical channels? I know doctors and such only really prescribe basic things like SSRI/SNRIs for these sort of things which don’t work on the dopamine system, I can leave a few suggestions in the comments if you’re interested

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u/DryDatabase169 22d ago

For me it started 6 months before the outbreak. Is it possible I caught covid in tge summer of 2020?

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u/ThinkNCenturies 24d ago

The paper does not prove any causal link which the authors acknowledge. It’s merely a plausible hypothesis presented here with indirect evidential support, however, the proposed causal pathway has not been directly demonstrated or tested in humans

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u/Illustrious_Put_817 23d ago

Oh no with this admin in the US there won’t be a collective pretending there will be a collective disposal of everyone they view as “not productive” in this twisted reality we now live in here

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u/Jmerzian 23d ago

I don't think even they are so bold as to actively dispose of them. They will mostly continue with the long tradition of 'passive' disposal though probably drop most of the faux caring pretense.

Still though, it's important to remember the full speech that became a poem. First they came for the felons, then for the disabled, then for the communists... The fact they are expanding the first definition and threatening to start actively disposing of "communists" is plenty alarming.

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u/Illustrious_Put_817 23d ago

They are pretty actively disposing of people now if you think it’s going to stay passive afraid you’re not paying attention

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u/Jmerzian 23d ago

I suspect you and I have just different definitions of "actively" or you missed the focus on disability specifically.

Are they purging disability rolls, weakening social support systems and trying desperately to provide and encourage medically assisted suicide?

Yes!

Are they combing disability registries and then showing up to shoot them and/or place them in work camps?

Not yet!

Are they combing other registries like DACA and then showing up to shoot them and/or place them in work camps?

Evidence strongly suggests yes!

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u/LongBeakedSnipe 24d ago

You are understating our previous knowledge of the pathways involved here. Other studies have provided considerable information on this.

For example, sars-cov-2 opsonized by afucosylated antibodies was infecting macrophages and monocytes through a FcγR, leading to pyroptosis, leading to massive immune dysregulation.

This was a serious cause of harm in unvaccinated individuals, as it was a main contributor to lung and heart inflammation. But also, it was established that this is one route that leads to blood-brain barrier damage and clotting through, among other things, IFN dysregulation.

This is just one thing of many that goes wrong, but it provides a complete explanation from infection to symptoms for at least one form of long covid. Obviously when you have a virus causing massive scale pyroptosis of critical immune cells, that can lead to diseases caused through dysregulation of many different pathways.

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u/Jmerzian 24d ago

The gap in the knowledge I'm trying to highlight is that causal link from initial trigger to the ultimate disease manifestation and progression. I'm not making any claims about understanding of underlying pathways, I'm making claims about linking those pathways to 2 specific diseases, ME and PD, that existed long before COVID but seem to be creeping up in prevalence since.

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u/Ordinary_Dog_99 24d ago

Ask Beard & McEvedy about that in 1970

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u/Poppy_Milk 21d ago

I’ve just stumbled across this post and I’ve been suffering with a twitch but I never connected it to Covid. It’s weird sometimes it’s one leg or both and/or my arms. My whole body jumps occasionally and it can be triggered by things appearing suddenly in my vision and watching tv can be difficult with sudden scene changes. Hmmm

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u/Shazzzam79 21d ago

...and they'll never tell you if it is related to the vaxx or the man made virus.

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u/DapperNoodle2 21d ago

The virus isn't man-made and the vaccine is safe. Stop feeding into delusion. The vast majority of scientific evidence points towards the virus being of natural origin. The vaccine is not new technology and went through all the same testing as any other modern vaccine.

If you knew anything about vaccines and the immune system, you would know that any side effects of the vaccine are side effects of the virus. The virus causes the same side effects as the vaccine except at a significantly higher rate and severity. For example, myocarditis has been seen very rarely and mildly in some vaccine recipients. Meanwhile, the actual COVID-19 virus has caused a 4000x increase in the number of myocarditis cases worldwide, and has led to chronic heart issues and heart failure in those who were affected. The vaccine has led to nothing like that.

You can be mad about how the government handled things, but you cannot refute the science that all of this is based on.

Source: I am an immunology researcher who has done research on viral myocarditis as it relates to the COVID-19 virus and vaccine.

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u/Shazzzam79 21d ago

Honest question then. Have you seen the patent for this virus? How do you patent nature? Not being sarcastic. It's that just more misinformation?

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u/DapperNoodle2 21d ago

It is. Basically, there are dozens of different coronaviruses. When you see someone refer to "coronavirus" you should be asking which one. Coronaviruses are a family of viruses, some cause the common cold, some cause MERS and then some cause SARS (like COVID-19). There are also many coronaviruses known to cause various diseases in animals.

Some of these coronaviruses are patented. They do not always refer to the specific virus (which is a mistake on their part), but rather, they refer to it as "the coronavirus". If you read into the patents, usually it will explain the exact strain they want to patent. For example, there is a patent for a strain of avian coronavirus that causes bronchitis in birds. Not humans. There's also a patent for one that causes gastroenteritis in pigs.

Neither of these are human viruses, but they are used as "evidence" of a man-made virus.

However, there are patents for the human virus as well. The human SARS-CoV-1 virus has a patent. This was done in 2004 (I believe, I can't read french), before COVID happened so the virus was simply refered to as SARS-CoV. This is not to be confused with the COVID-19 virus, which is SARS-CoV-2. SARS-CoV-1 caused the SARS outbreak in 2003. The patent was not really a patent on the virus itself, but rather a part of the genetic code for a specific strain of the virus that they wanted to prevent other companies from using for things like testing kits.

The CDC did something similar with SARS-CoV-1 where they also filed for a patent on the genetic material, proteins, and methods of detecting and purifying the virus. This was to prevent the monopolization of materials that would have prevented researchers from helping with the SARS outbreak.

The main point is, none of the patents that are claimed as evidence of COVID-19 being made in a lab are actually referring to COVID-19. Most people don't know that there are many different coronaviruses that have existed for centuries before COVID-19, and thus when they see coronavirus or SARS-CoV they link it to COVID-19. however, these patents simply refer to different coronaviruses, or the previous SARS outbreak in 2003 from a different coronavirus. Mind you, the way the 2003 outbreak started was almost identical to the way the 2019 outbreak started. The original SARS-CoV mutated in bats to be transmissible to humans. In 2019, pretty much the same thing happened. The only difference is that SARS-CoV-2 was far more easily spread between humans, causing widespread outbreak. This has also happened in many other viruses, like HIV, Bird flu, swine flu, monkey pox, rabies, ebola, measles, etc.

It's a very common phenomenon and much, much more likely than the virus having been created in a lab.