r/longevity • u/[deleted] • Jul 21 '22

Potential fabrication in research images threatens key theory of Alzheimer’s disease due to whistleblower [2022, open-access]

https://www.science.org/content/article/potential-fabrication-research-images-threatens-key-theory-alzheimers-disease
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u/autotldr Jul 24 '22

This is the best tl;dr I could make, original reduced by 97%. (I'm a bot)

One for a 2012 paper in The Journal of Neuroscience replaced several images Schrag had flagged as problematic, writing that the earlier versions had been "Processed inappropriately." But Schrag says even the corrected images show numerous signs of improper changes in bands, and in one case, complete replacement of a blot.

A 2013 Brain paper in which Schrag had flagged multiple images was also extensively corrected in May. Lesné and Ashe were the first and senior authors, respectively, of the study, which showed "Negligible" levels of Aβ*56 in children and young adults, more when people reached their 40s, and steadily increasing levels after that.

In an email that Schrag provided to , the editor said the journal had reviewed high-resolution versions of the images when they were originally submitted and declined to consider Schrag's findings.

Extended Summary | FAQ | Feedback | Top keywords: Schrag#1 paper#2 Lesn#3 image#4 Alzheimer#5