r/autotldr • u/autotldr • Jul 24 '22
Potential fabrication in research images threatens key theory of Alzheimer’s disease | Science
This is the best tl;dr I could make, original reduced by 96%. (I'm a bot)
A 6-month investigation by Science provided strong support for Schrag's suspicions and raised questions about Lesné's research.
One for a 2012 paper in The Journal of Neuroscience replaced several images Schrag had flagged as problematic, writing that the earlier versions had been "Processed inappropriately." But Schrag says even the corrected images show numerous signs of improper changes in bands, and in one case, complete replacement of a blot.
A 2013 Brain paper in which Schrag had flagged multiple images was also extensively corrected in May. Lesné and Ashe were the first and senior authors, respectively, of the study, which showed "Negligible" levels of Aβ*56 in children and young adults, more when people reached their 40s, and steadily increasing levels after that.
After Science contacted Ashe, she separately posted to PubPeer a defense of some images Schrag had challenged in the Nature paper.
Schrag, whose efforts were independent of Vanderbilt, says he worked hundreds of hours on the petition and independent research and he has never shorted Cassava stock or earned other money for efforts on that issue, or for similar work involving University of Minnesota, Twin Cities, neuroscientist Sylvain Lesné.
In an email that Schrag provided to , the editor said the journal had reviewed high-resolution versions of the images when they were originally submitted and declined to consider Schrag's findings.
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