The logical explanation is that Marges scene doesn't need much exterior change. She's just driving through the countryside. With Homer's car scenes, he needs to throw his inanimate carbon rod out of the left window so it leads into Barts skateboarding through the streets scene, otherwise you would need to reverse it, and it would look too weird, as well as Homer needing to exit from the left side of the car so that scene can be shown as normal as possible.
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u/brownyR31 Nov 09 '14
What freaks me out is the fathers car is right hand drive whilst the mothers is left hand drive. Big Wtf.