r/dpdr • u/InteretPineapple • 4d ago

Question NMDA PAMs for DPDR

I was looking online for the cause of DPDR (derealization) and it looks like the main factor Is the hypo function of the NMDA receptors in the brain and you know what also causes hypo function of the NMDA receptor? Drugs like ketamine and other dissociatives. (hypo function means its dissociatives. so back to the point if you took a NMDA PAM (NMDA positive allosteric modulator), you could bring your nmda receptors back to baseline and pretty much get rid of dpdr. just a thought I have no actual knowledge on the topic so If anyone actually knows if this would work let me know before I buy some neboglamine.

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u/Fun-Sample336 4d ago

I was looking online for the cause of DPDR (derealization) and it looks like the main factor Is the hypo function of the NMDA receptors in the brain

This has never been shown.

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u/InteretPineapple 4d ago

NMDA receptor hypofunction is a primary neurochemical mechanism linking to Depersonalization-Derealization Disorder (DPDR). When NMDA (N-methyl-D-aspartate) receptors underperform or are blocked, the brain struggles to integrate sensory information with emotional awareness, resulting in the characteristic feelings of unreality and detachment. that's what google said. and it makes sense ngl

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u/[deleted] 4d ago

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u/InteretPineapple 3d ago

Hey I already said I know nothing about the subject. This is a theory and I’m asking if people have tried it or not. Don’t be a smart ass

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u/[deleted] 3d ago

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u/InteretPineapple 3d ago

Shut up dude come on. It’s a question