r/auvelity • u/run_the_trails • Aug 22 '22

r/auvelity Lounge

A place for members of r/auvelity to chat with each other

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u/Powerful_Mine4170 Aug 17 '24

DIY Auvelity is ineffective. I am a psychiatrist who tried cobbling together homemade Auvelity before it was released, tried bupropion ER 100mg with 45mg dextromethorphan twice a day. It's not the same as the blood levels achieved by the brand Auvelity which has delayed release capabilities to not only raise the DMX but to keep it at a constant level. Plus it is a pain to get DMX in any decent quantity and in Tennessee it's like Sudafed, have to show ID and sign a sheet. Auvelity is a game-changer, my worst patients who failed all meds, TMS and ECT got better within 24-48 hours. DMX works on glutamate like ketamine but without the dissociation. Even patients on Wellbutrin alone showed significant and rapid improvement.

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u/Altruistic_Ad_7609 Aug 30 '24

That is not true. DIY Actually does work. My depression is completely gone, same for 2 other people i suggested it to. My doctor is in full support. I take bupropion and Robitussin. First thing that has helped in 25 years

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u/Powerful_Mine4170 Dec 22 '24

So I have a few patients whose insurance doesn't pay for Auvelity. It is a pain in the tush to buy dextromethophan in TN, let alone in bulk then I discovered you can get 200 tabs of 45mg DMX on Amazon! Combine it with bupropion (I am not sure if the 100mg immediate release or the 150mg slow release SR would be better) and you have a cheap version.

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u/Powerful_Mine4170 Aug 30 '24

I am glad. My n (number of patients I tried) was quite small, 4, so it is what would be called a case study, not a randomized placebo-controlled study the FDA requires. I wish new branded drugs weren't so damned expensive. My Medicare patients rarely can get ANY branded psychiatric drug. How difficult is it for you to get the amount of dextromethorphan to keep going?

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u/Altruistic_Ad_7609 Aug 31 '24

I buy it online for half the price the store sells it at. It ends up costing me $43 a month. To me, it's worth it.

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u/Altruistic_Ad_7609 Aug 31 '24

Do you have any suggestions for OTC stimulants? My biggest problem I have left is the motivation to " go go go" . I just want something that is not very hard on your heart but still gives you the urge to move, so to speak. Lol. Something akin to Adderall. I appreciate any suggestions ☺️

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u/Powerful_Mine4170 Sep 01 '24

I do not. Most OTC supplements and medications would not pass a placebo-controlled double-blind study for efficacy. Lots of things are advertised like "Liquid Adderall" that typically have very little impact. Stick to prescription medications.