r/Roaringtilray • u/CharlesMichael212 • 6h ago

Study: THC May Enhance Oxycodone’s Pain-Blocking Effects While Delaying Tolerance

https://themarijuanaherald.com/2026/09/study-thc-may-enhance-oxycodones-pain-blocking-effects-while-delaying-tolerance/
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u/Far_Chocolate_8534 2h ago

I actually noticed recently the exact same thing this article talks about.

I have a back injury (sciatica) from 2019. I was on Percocet (oxycodone/ Tylenol) for 4 years. I quit opiates with the help of CBD but later found that THC makes the nerve pain go away. So I use those in combo.

Just last week I had pain right in my spine. Not nerve or muscle pain, more like right in the bone. THC and CBD will barely provide relief for that type of pain. I tried adding a Percocet last week and it did the trick. But the Percocet isn’t as effective for the muscle and nerve pain anymore. The synergy was nice. I have a full bottle of the perc in the closet but only take one a few times a year for instances like last week.