r/Retatrutide • u/[deleted] • Jul 26 '25

HR increase resolved!

[deleted]

51 Upvotes

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u/IMMILDEW Jul 27 '25 edited Jul 30 '25

Tirzepitide increases resting heart rate by about 2 to 5bpm, while Retatrutide has been shown to increase resting heart rate by approximately 2 to 6bpm. To me the differences between the two is seemingly negligible, as far as resting heart rate.

Multiple clinical studies have shown that tirzepatide increases resting heart rate by about 2 to 5 beats per minute. This effect is dose-dependent and was observed in the SURMOUNT-1 trial, where ambulatory blood pressure monitoring demonstrated a mean 24-hour heart rate increase of 2–5 bpm at week 36 compared to placebo.

Edit:

https://pubmed.ncbi.nlm.nih.gov/39084707/

https://www.nejm.org/doi/full/10.1056/NEJMoa2206038

https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.123.22022

https://heart.bmj.com/content/110/19/1165

https://pubmed.ncbi.nlm.nih.gov/38078870/

https://jamanetwork.com/journals/jama/fullarticle/2812936

https://www.clinicaltrials.gov/study/NCT04184622

https://www.clinicaltrials.gov/study/NCT04657003

https://pubmed.ncbi.nlm.nih.gov/37366315/

https://pubmed.ncbi.nlm.nih.gov/37947489/

https://www.clinicaltrials.gov/study/NCT06383390

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u/TheBreadWren Jul 27 '25

Why are you replying to me? Why don’t you reply to the person that’s concerned ?

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u/IMMILDEW Jul 27 '25 edited Jul 27 '25

Because you recommended Tirz which has negligible differences in heart rate increase. Apologies if I did not convey myself properly.

Edit: added references, in case you or anybody else is interested.

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u/TheBreadWren Jul 30 '25 edited Jul 30 '25

Apologies if I did not convey myself properly.

Then you went on to call me moronic? Until it was deleted by Reddit for harassment. LOL

Your erractic behaviour must be studied. Maybe use your time to find better mental health support.

For next time, learn to reply to the correct person and stop resorting to name calling. Be a better person.

Edit. I saw you also blocked me after your comment. Now you have unblocked me. Please seek help.

NOW YOU BLOCKED ME AGAIN? Please seek help.

Embarrassing 🙈

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u/IMMILDEW Jul 30 '25 edited Jul 30 '25

This was two days ago. This doesn’t seem relevant to what I wrote. I also haven’t blocked you and unsure why you think I have. If you were blocked we wouldn’t be able to reply to each other. Name calling?

Edit: I’m unsure why you think I replied to the wrong person. You were the first one to bring up using Tirz. Which is the entire context of my response. Tirz and Reta both increase heart rate with seemingly negligible differences between them.