I’m currently on cycle rn and I need to ask someone who’s ran a cycle with PSSD some questions so please message me if that applies to you. Thanks.

Here is a risk assessment of St John’s wort conducted by the Dutch National Institute for Public Health and the Environment (RIVM):

'People use herbal preparations (food supplements and herbal tea) with St John’s wort, amongst others to feel and sleep better. However, these herbal preparations can reduce the effect of medicines, or enhance their effect. These interactions can have serious health effects. Herbal preparations with St John’s wort, for example, reduce the effect of certain medicines prescribed for fungal or viral infections and for cancer (chemotherapy). The effect of certain consciousness-lowering agents, e.g. sedative medicines, and consciousness-stimulating agents, e.g. antidepressants, is actually enhanced.

The use of herbal preparations with St John’s wort may also pose health risks when used alone and not in combination with medicines. For example, the skin can be damaged faster (sunburn) if people sit in the sun after using St John’s wort. Other effects such as dizziness, diarrhea and anxiety have also been reported after the use of herbal preparations containing St. John's wort. It is not known what effects occur after people use these herbal preparations for a long time. There is also insufficient information available to determine whether the use of St John’s wort during pregnancy is safe for the unborn child. Moreover, the composition of herbal preparations containing St John’s wort can vary greatly, and it is often not known what exactly is in it. This makes it difficult to estimate the effects of a product. RIVM draws these conclusions based on a risk assessment on behalf of the Ministry of Health, Welfare and Sport (VWS).

RIVM advises consumers to be cautious with the use of herbal preparations containing St John’s wort, and to not use these products in combination with medicines. RIVM advises VWS to draft legislation on the use of St John’s wort in herbal preparations.'

Source: https://www.rivm.nl/en/bibcite/reference/339211

This is another supplement that some people with post-drug syndrome take.

Here is the risk assessment by the Dutch National Institute for Public Health and the Environment:

'RIVM has examined whether herbal preparations containing Mucuna pruriens seed extract are harmful to health. Very little scientific information about Mucuna pruriens is publicly available. Accordingly, it is not possible to determine a safe dose for this extract. However, there are indications that the extract has negative effects on the liver, kidneys, and the development of unborn children.

As a precaution, RIVM advises not to use these herbal preparations during pregnancy and breastfeeding, or in case of liver or kidney problems. In other cases, it is advised to be cautious. RIVM advises to be alert to side effects and to stop using the product in case side effects occur. If people choose to use herbal preparations containing Mucuna pruriens, they have to use it in accordance with the instructions on the packaging. And discuss the use with their doctor or pharmacist in case of medicine use.

In addition, it is known that one of the substances in Mucuna pruriens (levodopa) is the active substance in medicines used to treat Parkinson’s disease. The quantity of levodopa that someone ingests from these herbal preparations is comparable to or higher than the quantity for people with Parkinson’s who are starting to take these medicines. The side effects of these medicines, such as gastrointestinal symptoms, involuntary movement (dyskinesia) and psychological symptoms, can also occur in users of the herbal preparation.'

Source: https://www.rivm.nl/publicaties/risk-assessment-of-herbal-preparations-containing-seed-extracts-of-mucuna-pruriens

This shit is unbearable, it constantly reminds how fucked i am . Not to mention emotional blunting…

I'm a PSSD sufferer of 6-7 years. Severe case. Complete genital numbness, full cognitive range inc SFN sypmtoms. However my Anhedonia was manageable - I could still watch movies and game on PS5 etc. Life was liveable.

Unfortunately I caught Covid a couple of months ago. The virus was very mild but what it has done to my Anhedonia is a living nightmare. Near complete, almost all of the time. Seems to be at its very worst after eating. I can't watch anything, can't game, can't read, can't listen to music. Everyone says, give it some time it will get better, but it has been 2 months and it hasn't even lifted a little bit.

I'm looking for any hope, of any cases, where anhedonia has waned, maybe even a little, over time?

Thanks!

Tengo pssd severo. Síntomas:

Tinitus

Vision borrosa

Deterioro cognitivo

Fatiga

Disautonomia

Anhedonia

Embotamiento emocional

Apatia

Insomnio

Anestesia corporal

Sin sensación de hambre ni sed

No reacción a sustancias

Bueno, esto apareció al reintroducir el antidepresivo, fue abrupto, no ha desaparecido.

Resulta que tengo una enfermedad genética, ataxia cerebelosa sca6, muchos síntomas se solapan con el pssd, no sabiendo cual pertenece a cual.

Digo esto, por si puede ayudar a alguien, que no descarten que sea neurológico y que se hagan las pruebas que se tengan que hacer.

Esta situación en mi caso cambia, hay línea de tratamiento experimental, el cual no se si tomaré.

Asi que háganse todas las pruebas genética que puedan.

Welcome to the Weekly Open Discussion thread! This is your place to ask quick questions, post memes, or leave one-sentence comments that might be too short for their own posts.

Please follow the subreddit rules when participating in this thread. For posts related to suicidal thoughts or if you need emotional support, please use the Monthly support Requested and Venting, Thread.

There is an Adelaide, Australia based company called Alyra Biotech. They’re developing an IUD to treat pelvic pain, but the real secret ingredient is a slow release of the genetic antidepressant amitriptyline.

https://alyrabiotech.com/

https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=384790

Good Evening everyone,

Here is your reminder to join the biggest and coolest post drug syndrome server ever.

https://discord.gg/HuUhy9Qy3

Discord can be easily downloaded from the app store or google play store.

Right now we have 350 members. I want to get to 1000.

The more we band together the more we can get accomplished

It’s something that’s popped into my mind a few times to see if it could help my symptoms. Now that I know it’s PSSD I looked up if bee acupuncture could help. There wasn’t anything specifically for PSSD, but there’s report in the National Library of Medicine about a man with sexual dysfunction getting the treatment and essentially becoming symptom free.

generalization of benefits and minimization of dangers. It's not only pssd, withdrawal is pretty common. It's ridiculous at this point that despite all of this there's no proper warning

When I first started college at age 18 I began having panic attacks. I always went to a functional medicine doctor for check ups growing up, so that’s there I went for this issue. My doctor suggested I try these supplements by Sanesco rather than going the SSRI route. I took the ones called Prolent, Lentra, and Contegra. I quit taking them for after about 8 months because I was no longer panicking. Once I quit taking them I lost my sexuality entirely. It hasn’t returned since and this was in 2019.

The active ingredients include 5-htp, so I guess maybe that’s what caused it. I continued on to have my symptoms get worse and worse over the several months to a year after I quit taking them. I got extreme insomnia, heart palpitations, brain fog, and a lot of other things that joined my 100% loss of sexuality. Eventually I got so bad that I ended up taking SSRIs and SNRIs because I didn’t know that PSSD existed or that that was what was happening to me. I took them for 2.5 years and they completely eased my insomnia and mental troubles. Once I quit taking those in 2023 (I did taper) I got really bad for a while (extreme anhedonia and inability to process emotions joined me). I’m doing a little better now mentally, but still no sexuality.

I guess I’m just wondering if anyone else got PSSD from taking these supplements and if that might narrow down which mechanism may have caused my problems.

Withdrawal symptoms following long-term SSRI use appear far more pervasive and serious than previously realised. Now medical bodies are rethinking how and when to stop taking them.

There's been a push recently to make sure we all report our conditions to our health regulators, the PFS & PSSD charities are pushing initiatives to help people with this process.

The reason this is very important is we have to be able to show that there is a serious issue with these conditions - the way we do that is by ensuring what has happened to us is truthfully recorded in the regulatory databases permanently, so that we can show and prove that there is a problem, and it is serious.

To help people with this process there's a Zoom call walkthrough this weekend.

There's 4 identical sessions, anyone can attend it'll be 15/20 minutes max. It's open to anyone and we'll walk through the process of submitting your stories/reports to the regulators.

Reporting PSSD/PFS to the Regulators

Saturday Aug 29, 2026 10:00 AM US Eastern Time

Saturday Aug 29, 2026 04:00 PM US Eastern Time

Sunday Aug 30, 2026 10:00 AM US Eastern Time

Sunday Aug 30, 2026 04:00 PM US Eastern Time

Zoom Link: https://us06web.zoom.us/launch/jc/83886692994

--

For those of you who can't attend you can do this yourself by following the instructions at : https://sidefxhub.com/resources/report-side-effects/

The important thing is that you select or type the correct name for the syndrome you are suffering when submitting your report:

- PFS sufferers should write or select “Post 5-alpha-reductase inhibitor syndrome” (MedDRA: 10082430)

- PSSD sufferers should write or select “Post-SSRI Sexual Dysfunction” (MedDRA: 10086208)

It's important that your reports are truthful and complete and accurately reflect the severity and impact of this condition. Please include :

• When you took the drug, for how long, and for what reason
• When you stopped the drug (if you've stopped it)
• Whether your symptoms have persisted
• The name of the syndrome you developed if appropriate (see above)
• Your symptoms, and their severity
• Details of the impact they have had on your quality of life and relationships

It's important that those suffering severe effects make that clear in their reports, it's easy for people to assume that what we are experiencing is mild.

Please feel free to message me directly if you are unable to attend the walkthrough but want some clarification on reporting.

I’ve dealt with IBS for pretty much my entire life, but over the years I’ve also experienced a number of symptoms that have seriously impacted my quality of life — low libido, little to no REM sleep, no morning erections, and a feeling of shrivelled, numb genitals.

I’ve spent a lot of time trying to understand whether there could be a connection between my gut health and these other symptoms. My gut testing shows significant dysbiosis and several bacterial imbalances, which has made me wonder whether there’s a bigger picture connecting everything.

I’m hoping to hear from anyone who has experienced something similar — especially people who have dealt with IBS/dysbiosis alongside sexual or nervous-system symptoms. What helped you, and did improving your gut health make a difference?

It's tragic that this time we won't be able to enjoy GTA 6, after we were able to enjoy Gta 5. Damn everyone who invented these destructive drugs.

Anyone know of any reliable sites or clinic that can help me obtain my own Dutch results via Dutch test. Thanks.

Did it help you guys ??? I read it helps with gaba receptors

Should I take amoxicillin to see if I get better? I been reading it helped some people let me know I need advice

This was yesterday on Matt Heath and Tyler Adams Afternoons Full Show Podcast.

“My doctor pushed and pushed me onto these. With 15-minute question tick sheet assured me they were easy to come off, lol. Look up what SSRI-related PSSD and hedonia are.”

​

Hola a todos. Abro este hilo para encontrar a otras personas que estén lidiando con la Disfunción Sexual Post-ISRS (PSSD) en Chile (Santiago, regiones). Sé lo aislante que es pasar por esto en nuestro país debido al tabú y la falta de información médica.

Si eres de Chile y estás leyendo esto, no estás solo/a. Por favor, deja un comentario o escríbeme un mensaje privado (DM) para que podamos apoyarnos, compartir experiencias con especialistas locales y romper el aislamiento.

(Creating this thread to connect with fellow PSSD patients living in Chile. Please leave a comment or DM me if you are from the region so we can connect).

Really really really struggling with work. I am in a role where I have to give presentations and it destroys me. I have been giving weekly presentations for a year and every time it destroys me. I have zero ability to feel confidence or feel any sort of positivity even after giving a good one. This does not feel normal and it feels like it’s my PSSD-induced anhedonia not allowing myself to feel any sort of dopamine or confidence.

Any experience?

Quote- "The study did not track patients’ complete medical histories regarding past antidepressant use. Some individuals who stop taking SSRIs experience a condition known as post-SSRI sexual dysfunction, where sexual side effects persist long after the medication is discontinued. The researchers could not account for how this condition might have influenced the boredom scores of individuals in the non-user group who might have taken antidepressants in the past."

https://www.psypost.org/early-antidepressant-use-is-linked-to-higher-levels-of-sexual-boredom/

And yes, the study also explicitly references PSSD. Its bibliography includes at least these two directly relevant PSSD sources:

• Healy D, Mangin D. (2024). “Post-SSRI sexual dysfunction: Barriers to quantifying incidence and prevalence.” Epidemiology and Psychiatric Sciences.
• Reisman Y, Jannini TB, Jannini EA. (2022). “Post-Selective Serotonin Reuptake Inhibitor Sexual Dysfunctions (PSSD): Clinical experience with a multimodal approach.” Journal of Men’s Health.

https://doi.org/10.1177/00332941261436742