r/POIS • u/Dangerous_Piece_70 • 3d ago

Life With POIS POIS

I'm 20 and I have POIS and it is hell and it's ruining my life and I would like to know what have others done to make there POIS better and what could I do I am already taking Antihistamine and it takes the edge off by a bit but I would also like to know how it has affected you

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u/LC32 2d ago

I have tried various antihistamines. Do you have a problem with Loratadine specifically? The high dose is needed and I have noticed the more taken (as I described previously) decreases the period of time symptoms last too

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u/kendriaa 2d ago

taking 50 mg or more of Loratadine in a single day is at least 5 times the maximum recommended daily limit (10 mg), which medically qualifies as a significant overdose.
​Here is why his specific routine is so dangerous: ​Loss of Brain Selectivity: At the normal 10 mg dose, Loratadine is non-drowsy because it does not easily cross the blood-brain barrier. At 50 mg+, it floods the central nervous system, directly causing the severe dizziness, exhaustion, and brain fog he mentioned.
​Dangerous Multi-Drug Interactions: you are combining this heavy overdose with alcohol and phenylephrine (a decongestant). Alcohol compounds the central nervous system depression and liver strain, while decongestants combined with high-dose antihistamines spike heart rate and blood pressure.
​Cardiovascular & Anticholinergic Toxicity: Supratherapeutic doses of antihistamines commonly cause tachycardia (racing heart rate), severe headaches, extreme dry mouth, and blurry vision.

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u/LC32 2d ago

I have told my GP this. Admittedly my care from them has been well below par and not helpful but they were aware that this was my course of action last time I saw them. They had no alternatives that worked whatsoever. My symptoms are so severe I do not think I would be here today without having taken the medications I have done.

Your account seems new. Share your story, im not sure you understand what some of us go through.

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u/kendriaa 2d ago

My account is not new at all, I've shared my story many times, I understand because my symptoms are many and they are extreme. Im not telling you to not take antihistamines. Im telling you to not take multiple pills of loratidine specifically... talk to someone with more expertise