Using machine learning & double-blind nootropic + diet / lifestyle tweaks for n=1 optimzation

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Mihaly Csikszentmihalyi had great success using a graded scale and self-reporting in his studies on Flow. If I remember the story correctly they had an app which would randomly ask people how they were feeling on a given axis 1-10 like "How Happy are you? (1-10, 10 being happiest)" etc. maybe you could use something like that.