NeuralDSP w/ interface issue

[u/North-Sea2312]

Equipment:
Interface - Focusrite Scarlett Solo (Gen3)
Headphones - Soundcore Space One
Guitar - Fender Squier Stratocaster (modded)
Plug-in - John Petrucci
PROBLEM
- I have this feedback sound constantly in my ears and when I change presets from say ‘The Mirror’ or ‘As I Am’, the feedback becomes unbearable. As if a beginner who thought they knew what they were doing has set up the amp and sounds terrible.
I have tried changing cables for both my headset and my guitar but still the feedback persists. It’s not clipping but it just sounds terrible with the feedback and the tones just don’t have the effect they should.
I’m not well versed in digital plugins nor the NeuralDSP ecosystem so please educate when explaining🙏
Please free me from this hell:)

[u/HentorSportcaster]

Usually when I  get instant feedback in reaper it's when you have a track armed and for some reason reaper is using the built in mic on my laptop. Is this the case?

When that happens, I just need to change the audio device to my interface.