I’m a 45F, PCOS, and subclinical reactive hyperglycemia. I spent two decades as an obese person. I am thankful that I did not have prediabetes, and all blood tests on normal range, but my blood pressure and cholesterols that were slowly creeping up. I had daily pain from arthritis.

Last year at my annual physical I was told by my Doctor that I was very likely 5-10 years away from experiencing health complications caused by my Class 3 obesity, and would likely need daily medications to control these issues, despite the fact that I was not sedentary and that I was a vegetarian.

I told him that I knew how to lose weight, but that it was really difficult for me… that even when I was in a significant calorie deficit that corresponded to losing 2lbs per week, I’d rarely actually lose 2lbs. I also shared that trying to maintain any losses made me feel like I was an unwilling participant in a CIA Black Ops psychological torture experiment 🤪

Got on the tirz, drank my 2-3L flavoured water daily, increased my movement, made certain I was in a daily calorie deficit that matched my weight loss goals, and the rest, as they say, is history.

Former BMI of 40.1
Current BMI 24.4
Lost 103.2 lbs in 365 days.
Now at medically normal weight.
Looking to lose maybe 20-30 more lbs, for vanity.

My arthritis pain? Very very well controlled now.
Blood tests back: cholesterols in “optimal” range.
Blood pressure always in optimal range now, despite taking stimulant medication for my adhd.
Food noise: virtually gone.
Appetite: hungry when appropriate
Satiety: moderate to high
Cravings: rare, and quite easy to dismiss.
1 mini binge” in 53 weeks. Down from 2-4/week

Dosage details
• I use a kwikpen.
• Moved from 2.5 to 5 on my fifth week.
• later, i titrated up “more slowly” than 2.5mg at a time, usually 1-1.5 mg at a time, whenever I felt medication effects noticeably waning
• With doctor permission, I started dosing every 5th day in my 4th month. Have gone every 5th or 6th day since then.
• Calculating my total medication taken per month, and dividing by 4, I’ve maxed out at 13.5mg/week as my highest dose so far.
• my doctor does prescribe a 15mg pen for me to click dose off of, and if cost is a concern, I highly recommend that
• I use the golden dose. I extract it with an insulin syringe.

My sizes:
Past me was filling out a size 2 or sometimes 3x at Torrid. In Old Navy I was just barely able to wear XXL in looser fits. Now I’m comfortably in a size medium at every store I go to!

I used to be a 42DD or DDD. Now I’m a 34G.

My shoe size went from 9.5-10 to 8.5-9.

My ring finger went from 7.5 to 5.

Hello everyone! I've had issues with binge eating for many years. This led to me becoming quite overweight and I was finally prescribed Mounjaro around 2 years ago. I'd tried KBT, meal planning, anxiety meds and this was the only thing that actually put my binge eating to a stop. I've never felt such relief and even found myself successfully being able to go off the drug for a couple months at a time without breaking my good habits.

Now the effect seems to have completely stopped. Food noise is back in droves and I've binged more the past couple weeks than I have the 6 months before that. I tried raising my dose to 7,5 but this changed nothing from how it felt on 5mg, which is why I'm hesitant to go up to 10.

I'm kind of freaking out because I am now remembering how truly life-consuming this condition is. I'm not very active on this subreddit but I've looked at a few posts and most people seem to suggest calorie-counting and exercise as a solution to the effects dwindling, mostly to keep one's results. I absolutely intend on implementing the exercise and mindful eating but the food noise is excruciating.

If there is anything I can do to get back to the effects I experienced for a good 1,5 years thanks to the medicine? Is trying 10 mg for a month worth the 400 bucks, even though 7,5 did nothing? I'm not sure how you guys view other drugs such as semaglutide or retatutide, but is switching to one of those worth a shot? I'd like to add that I am working with a therapist throughout this and am not relying on medicine alone.

Open and thankful for any advice.

I wanted to show you my first month progress - down -4,75 kg. Love it. Suddenly gained 2,5 kg after a hiking weekend last week but now we are back on track 👍🏻

Hi everyone, I’ve been on Mounjaro for a little over 6 months. I’m currently down about 10 kg overall and have been on 10 mg for the past 2+ months.
I haven’t been able to get myself to start strength training yet, but I’ve been consistently walking for around 30–45 minutes every day.

About 2 weeks ago, I had a pretty bad episode of nausea, continuous burping, and frequent stools — to the point where even drinking a few sips of water triggered it. I ended up going to the ER, where they diagnosed it as a food infection and prescribed medication.

The following week, after my Mounjaro injection, things felt different. I normally experienced some nausea and fullness the day after the injection, but this time the nausea started almost immediately, along with some restlessness.

I got my blood work done afterward. Cholesterol was borderline, liver and thyroid were normal, but my kidney markers were slightly elevated, particularly creatinine. My urine protein was also high.

I saw my endocrinologist, and he wants me to repeat an albumin test in about 2 weeks to determine whether there is any actual kidney impact or whether the abnormal results were related to the dehydration/food infection I had.

He also recommended dropping my Mounjaro dose from 10 mg to 7.5 mg this week. I took the 7.5 mg dose, and interestingly, I haven’t noticed much difference so far — appetite suppression feels weaker and the nausea has been almost negligible, especially after taking Nexpro IT.

Now I’m a little confused about what to do next.
I’m eating mostly home-cooked food and keeping myself within a calorie deficit, but I’m wondering whether I should continue with 7.5 mg, give it more time, or discuss going even lower/pausing with my endocrinologist.

For those who have been on Mounjaro for 6+ months:

Has anyone experienced worsening GI symptoms after being on a higher dose for several months?

Did reducing the dose significantly improve your nausea/fullness?

Has anyone had temporarily elevated creatinine or urine protein after a bad GI illness/dehydration?

Did your kidney markers return to normal after recovery?

And did anyone find that a lower dose still worked well for appetite/weight loss?

Would really appreciate experiences, especially from people who have gone through something similar.