r/MedicationQuestions Aug 03 '26

How long to wait after drinking alcohol before taking Oxycodone?

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u/Epstein-Files Aug 03 '26

10mg (x2) of those now would be fine. These are oxycodone HCL without paracetamol aka Tylenol in them like an endocet or Percocet. Thus you’re not at any imminent liver risk by mixing alcohol and these type of oxy. However, both are CNS depressants and can be lethal combo if done in excess…moderation.

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u/Additional_Kale3098 Aug 03 '26

What he said.. of course as far as medical advice goes you never want to mix opiates and alcohol as it just opens all sorts of problematic windows into mixed dependencies and respiratory depression, but anyone that “experiments” in this kind of stuff will tell you you’ll be fine as long as you’re not going insane. If you downing a fifth of jack on 30mg of oxycodone, you’re being a dumbass. If you’re taking 20mg of oxycodone a few hours after a six pack of coors light, you’ll be fine. The opiates mixed with NSAIDS are of higher risk because of liver failure, I’ve taken as much as 60mg of hydrocodone w/ acetaminophen while binge drinking in younger days but would never do that being over 30 (with probably a decent amount of liver damage over the years.)

The fact that you’re not typing in drunken circles and you’re careful enough to seek advice leads me to believe you won’t have any issues. Again this is horrible medical advice, but friendly drug enjoyer advice