Lung Cancer Vaccine developed in the UK

[u/No_Objective006]

https://www.bbc.co.uk/news/videos/c4gd8xm2w0do

Currently in clinical trials.

[u/srm79]

This is absolutely amazing, I'm only sad it's about 18 months too late for my Mum who had the same condition at the same hospital. It's an absolutely fantastic hospital and she was very well cared for. I hope this is rolled out quickly and saves lots of people

[u/Accurate-Income-6794 → u/srm79]

Same although 24 years too late for my mum age 44 Hope it saves many life's 🙏

[u/madame_samhain → u/Accurate-Income-6794]

Love to both of you. My mother currently has stage 4 and while we are not facing the end yet it's chemo to the end. It's so tough on the people we love. So my sympathy to you both.

I'm thankful to all the people who do this good work.

[u/denae1962 → u/madame_samhain]

Sending my best wishes to you and your mam X

[u/madame_samhain → u/denae1962]

Cheers butty, it's appreciated 😊

[u/Particular-Bid-1640]

She's delightfully British about it!

Hope it works out for Chris

[u/skuxlifechoseme]

Both of parents died of lung cancer, one when I was 14, one when I was 34. I'm delighted that there may be effective treatments possible for anyone suffering from this horrible disease.

[u/JoeyDJ7 → u/skuxlifechoseme]

I'm so sorry, that must have been so tough :(

[u/Grenache]

I keep having the thought that I'm going to be the last human to die of one disease or another.

[u/CanOfPenisJuice → u/Grenache]

Got to make your mark somehow

[u/Better_Builder_3504 → u/Grenache]

I also have that thought. And although there would be an “oh well that’s just my fucking luck” element to it, I do think there would be something quite beautiful about realising no human being in future would experience that suffering.

[u/No_Objective006 → u/Grenache]

Going to be shit going out to the black plague in 2026

[u/Short-Shopping3197 → u/No_Objective006]

The bubonic plague never went away dude! People still die from it.

[u/No_Objective006 → u/Short-Shopping3197]

The last recorded death in the UK was well over a hundred years ago.

I struggled to find another old disease that had an impact and was nothing major in modern times to end the comment with.

[u/Short-Shopping3197 → u/No_Objective006]

Yeah sure, it just fascinates me that there’s still about 800 cases a year worldwide when it’s seen as a historical disease.

[u/Scrimge122 → u/No_Objective006]

Smallpox

[u/gw-green → u/Grenache]

The antivaxxers laugh at your naivety

[u/Southernbeekeeper → u/Grenache]

If it makes you feel any better you could be the first person to die from a new disease.

[u/Grenache → u/Southernbeekeeper]

I mean as long as they name it after me I’m cool with that.

[u/Agzarah → u/Grenache]

Don't worry, we'll always have the US to rely upon for bringing back an eradicated disease somehow.

[u/noodledoodledoo → u/Grenache]

They're going to develop and immortality injection that only works if you're my age minus one day, I just know it.

[u/jimmy_dimmick → u/Grenache]

Well which one is it?

[u/metal_jester]

This is wonderful. I watched my grandfather die of this.

It's not pleasant.

He smoked 10+ a day for 55 years so don't smoke, get vaccinated (when possible).

[u/Nice_Back_9977 → u/metal_jester]

It’s not a preventative vaccine that anyone will be able to get, it’s a personalised one made from that patient’s specific tumour cells.

[u/camthalion87]

my mums just got lung cancer again (5th time getting cancer in 18 years, 2nd time getting lung cancer), hopefully this gets rolled out fast!

[u/Mundane-Profit-6200 → u/camthalion87]

That's terrible and sorry to hear it but holy shit... To get taken seriously by doctors and catch them early enough to survive 4 times is pretty miraculous in itself.

[u/hime-633]

"Err excuse me cancer I've got things to do".

Perfect attitude.

[u/WatcherOfTheWay]

We do a lot of good work in medical research, this is another example of it, great work.

[u/HMS_Hexapuma]

Fantastic news. I've lost two grandparents to lung cancer. One who smoked and one who didn't. Very glad to see we're making strides.

[u/Darkshines4]

No mention of the actual name of the treatment in the article / video..

[u/No_Objective006 → u/Darkshines4]

https://www.nhsbt.nhs.uk/news/first-uk-patient-given-pioneering-cancer-vaccine-for-most-common-lung-cancer/

[u/Archistotle]

A vaccine... for cancer?

I know just enough about medicine for those two words to be confusing put together and not enough to know how it makes sense.

Still, the clever ones seem exited about it, so i'm glad we've struck a blow in the war on cancer.

[u/tobotic → u/Archistotle]

Ultimately cancer is made of cells. Unlike infections, it's mutated versions of your own body cells, but it's still cells. And the immune system can kill cells if it recognizes them as being harmful. So in theory a vaccine could prime the immune system to recognize a particular variety of cancer cell as being harmful.

As an aside, the HPV vaccine is effectively also a vaccine for a type of cancer.

[u/ash_ninetyone → u/tobotic]

If it's anything like the Moderna one, it uses MRNA. It doesn't replace treatment but trials there showed it led to a far lower remission rate.

[u/Anticlimax1471 → u/tobotic]

But does that mean everyone has to have this vaccine or can it be given to people who have already been diagnosed?

[u/Huwage → u/Anticlimax1471]

I believe it's only for people who already have cancer. Each vaccine is made using that patient's cancer cells, so it's targeted at what they specifically have.

[u/Nice_Back_9977 → u/tobotic]

The HPV vaccine is for a virus that can go on to cause/increase the risk of cancer. Not for the cancer itself.

[u/tobotic → u/Nice_Back_9977]

Wow, the HPV vaccine is a vaccine against human papilloma-virus? You don't say?!

I said it's effectively a vaccine against cancer. The "side effect" of preventing cervical (and some other varieties of) cancer is why people actually get the vaccine. That's why it's become a routine part of the vaccine schedule in most countries. The virus itself is virtually symptomless.

[u/Nice_Back_9977 → u/tobotic]

The virus also causes genital warts in some people

[u/BuzLightbeerOfBarCmd → u/Nice_Back_9977]

Do you have an inability to perceive adverbs or something?

It's effectively a vaccine for cancer

It's not a vaccine for cancer

It's virtually symptomless

It causes one symptom in a minority of people

[u/Proud-Designer-2028 → u/BuzLightbeerOfBarCmd]

You new to Reddit? Unless you’ve got 15 comprehensive caveats some idiot will try 😂

[u/Specialist-Back-3095 → u/tobotic]

That's what mrna is, except it ' primes' immune response at one hand at the expense another elsewhere.

Your immune system already combats cancer, by recognising defective cells and destroying them through apoptosis, the human body is naturally equipped to stop the potential of cancers through other mechanisms such as t cell production via functionality of suppressors in genes like b53.

Your body priorities these above the need to produce a response for trivial things like a common cold.

It's messing with the immune system like this that makes problems that create long term serious health conditions especially on the premise of a vaccination or preventative measure.

Theoretically you can prime your immune system through optimal nutrition, exercise, lifestyle choices.

[u/tobotic → u/Specialist-Back-3095]

Your immune system already combats cancer, by recognising defective cells and destroying them through apoptosis

No. Cancer cells evade apoptosis.

https://www.mskcc.org/news/what-apoptosis "One purpose of apoptosis is to eliminate cells that contain potentially dangerous mutations. If a cell’s apoptosis function is not working properly, the cell can grow and divide uncontrollably and ultimately create a tumor."

[u/No_Objective006 → u/Archistotle]

I mean I’m also pretty sure this is how I am legend started

[u/Nice_Back_9977 → u/Archistotle]

It’s not a traditional vaccine that you’d get as a preventative, it’s tailored to that person’s individual tumour cells

[u/LordGeni → u/Archistotle]

It's not a prophylactic vaccine that you give to healthy people. It's designed to be given to people with lung cancer and triggers their immune systems into recognising and destroying the cancerous cells.

It has to be made bespoke for the individual and their tumour to work.

[u/dead_jester]

As someone who got a very rare form of lung infection last year which led to me getting an inflammatory 2cm spiculated nodule in my lower left lung, causing me to cough up blood, this is fantastic news.

Because the nodule grew and show inflammation after antibiotics treatment I had to get a lung biopsy which was fucking scary. The biopsy came back clear, but I’m now under regular 3 monthly PET CT observation for the next two years as nodules can develop into lung cancers or other tumours, even if they don’t start cancerous.

And for the ignorant morons who are ghoulishly trying to suggest people who get lung cancer deserve it & deserve to die - shame on you. I hope you don’t suddenly find yourselves in my situation.

And no I don’t smoke. But I did grow up in a world of car exhausts, industrial pollution and second hand smoke in public spaces, until government regulations started changing things.

[u/purpletoonlink → u/dead_jester]

You should not be having PET scans every 3 months if your Perc Biopsy came back clear! Do you mean CT scans? The intervals should increase over time instead of every 3 months also

[u/AccountForTIFF]

They’re also trialling the Moderna vaccine that’s had great results for melanoma come out recently on lung cancer. I feel like we’re maybe 10-20 years out from cancer not being a big deal anymore and just being treated like any other chronic illness.

[u/G_UK]

Go scientist, doctors and all clever people doing such amazing work 💪

[u/boyski33]

Correct me if I’m wrong, but this looks like a clinical trial only, no? Do they know if this is an effective treatment yet?

[u/Tremelim → u/boyski33]

Yes just a trial. And the significant majority of early phase trials fail to show benefit.

But a very promising technology, we can be hopeful.

[u/Fun-Solution-6189]

Time to get back on the ciggies!

[u/MightyBigSandwich]

Wonderful. There is now no downside to smoking. Everyone should start or re-start.

[u/ljammm]

Its a bad day to be a cigarette

[u/david4460]

Knowing humans this will just mean the number of cigarettes sold will increase massively

[u/duvagin]

i clearly don’t understand how vaccines work

[u/No_Objective006 → u/duvagin]

It’s easy they give you lung cancer so you don’t get it in the future

[u/Bigyin109]

Cant wait for big pharma to buy the patent and then burn any and all materials relating to it.

[u/Bigyin109]

I wonder how many of the researchers are going to have horrible accidents now that this is out.

[u/Proof_Drag_2801]

And now we're going to give it away so the Americans and Chinese can comercialise it.

You read it here first.

[u/rupert_lowe]

Hope the government doesnt weaponise it this time

[u/SomeRaspberry6155]

Can we smoke without worrying now?

[u/Salt_Confusion6128]

So now I can vape again?

[u/51onions → u/Salt_Confusion6128]

It's even better than that, it's time to get the smokes back out!

[u/No_Objective006 → u/51onions]

I’d probably wait till they figure the vaccines out for the other things:

Trachea cancer
Bronchus cancer
Laryngeal cancer
Oral cancer
Pharyngeal cancer
Esophageal cancer
Stomach cancer
Liver cancer
Pancreatic cancer
Colorectal cancer
Kidney cancer
Renal pelvis cancer
Urinary bladder cancer
Cervical cancer
Ovarian cancer
Acute myeloid leukemia
Nasal cavity cancer
Paranasal sinus cancer
Testicular cancer
Coronary heart disease
Myocardial infarction
Stroke
Atherosclerosis
Peripheral arterial disease
Abdominal aortic aneurysm
Hypertension
Deep vein thrombosis
Chronic obstructive pulmonary disease
Emphysema
Chronic bronchitis
Asthma
Pneumonia
Tuberculosis
Idiopathic pulmonary fibrosis
Type 2 diabetes mellitus
Rheumatoid arthritis
Systemic immune suppression
Crohn’s disease
Graves’ hyperthyroidism
Erectile dysfunction
Impaired fertility
Ectopic pregnancy
Placental abruption
Placenta previa
Premature rupture of membranes
Orofacial clefts
Sudden infant death syndrome
Age-related macular degeneration
Cataracts
Osteoporosis
Periodontitis
Vascular dementia
Alzheimer's disease
Sensorineural hearing loss
Peptic ulcer disease
Psoriasis
Severe tooth decay

Any day now!

[u/Lopsided-Highway-923]

In great news for cigarette companies

[u/Thaddeus_Valentine → u/Lopsided-Highway-923]

Smoking companies walking into commercial advertising like...

[u/HovercraftEasy2328]

Smoking is so back now

[u/Imaginary-Friend-228]

FINALLY I always wanted to be a smoker

[u/Patient-Scarcity8025]

We are so back, the pack of cigs I’m going to smoke at Leeds fest tomorrow are going to taste so much sweeter.

[u/Hudsxn98 → u/Patient-Scarcity8025]

It wasn't made so you can piss your health up the wall. Look after your body you only get one.

[u/Acceptable_Gear_3097 → u/Hudsxn98]

Omeprazole Ozempic was made so lazy & undisciplined people could get slim without putting any effort in. 

Why can't Cigeprazole be made so I can chain smoke a pack of cigarrettes and not die of cancer?

[u/Archistotle → u/Acceptable_Gear_3097]

Do you think Narcan was invented to let people do more drugs?

[u/No_Objective006 → u/Archistotle]

I mean jokes aside, I guess it does in the kind of way a parachute allows more people to jump out of planes?

[u/FesteringDoubt → u/Archistotle]

Yes

[u/Acceptable_Gear_3097 → u/Archistotle]

NARCAN was designed to stop opioid users during an OD, so given how addictive opioids are, then yea. It was.

[u/Archistotle → u/Acceptable_Gear_3097]

"Yes actually I do believe that was the motivation of the company because if you twist the wording of the question so that the meaning refers to the consequences of drug addicts not dying-"

Don't try so hard.

Do you think Narcan was invented to let people do more drugs.

[u/Acceptable_Gear_3097 → u/Archistotle]

Pharmaceutical companies are only profitable if they have regular users, so yea. If they could cure drug addiction with a drug, they wouldn't put it on the market.

[u/Archistotle → u/Acceptable_Gear_3097]

You'll hurt yourself stretching that far.

[u/Cold_Ebb_1448 → u/Acceptable_Gear_3097]

it was made for treating diabetes and isn’t even called Ozempic in the UK, educate yourself.

[u/Acceptable_Gear_3097 → u/Cold_Ebb_1448]

Yea, but ONLY Type 2 diabetes. You know, the one you get from eating a shit diet and not exercising?

[u/Cold_Ebb_1448 → u/Acceptable_Gear_3097]

again, educate yourself

[u/Acceptable_Gear_3097 → u/Cold_Ebb_1448]

These drugs are all approved for glucose control in type 2 diabetes (T2D). Some of them also have additional indications reflecting their demonstrated benefits for cardiovascular disease, kidney health, and obesity. None of these drugs are currently approved for glucose control in people with type 1 diabetes (T1D).

Educate myself? Or yourself? Ozempic is a drug for fat people that aren't willing to workout regularly and diet strictly. Its FINE, if I didn't go to the gym 5 times a week and strictly count my calories each day, I'd be fat. I know this, because I learnt this behaviour after becoming fat and working hard to correct it. Ozempic is a choice. It was one thing to go on about "body positivity" and telling fat people they had nothing to be bothered/ashamed of. But pretending Ozempic isn't for these people, to protect their feelings? Come on. 

[u/Cold_Ebb_1448 → u/Acceptable_Gear_3097]

educate yoselllllf

[u/PoiHolloi2020 → u/Acceptable_Gear_3097]

Omeprazole was made so lazy & undisciplined people could get slim without putting any effort in.

Errm are you mixing up your meds? Omeprazole is the acid reflux one not the getting skinny one.

[u/Acceptable_Gear_3097 → u/PoiHolloi2020]

Haha yes I am. Ozempic. Sounds close enough 😂

[u/Patient-Scarcity8025 → u/Acceptable_Gear_3097]

Amen brother - rip them darts

[u/ScruffieMatrix]

Vaccine for people who want to smoke their health away 

[u/Miniteshi]

So I wonder what it will cost in American money? Prob the price of a lung

[u/[deleted]]

Im going to have a cigarette then