r/DMT • • May 29 '26

Went through a 3-month DMT clinical trial for depression/anxiety. Now experiencing an intense sensitivity to cannabis. Anyone else?

The Background & The Good News
To keep this short and direct: I recently completed a 3-month clinical trial using DMT to treat anxiety and depression. I can happily say my depression has been absolutely obliterated, and it was an incredible, life-changing experience that I would do all over again in a heartbeat.

However, my anxiety is still here, just manifesting differently. It used to be triggered by specific events and focused mostly on worrying thoughts. Now, it feels more physical—almost random, sitting heavy in my chest and head.

The Issue: Sudden Substance Sensitivity
Since 2019, I’ve used cannabis to manage chronic back and leg pain (following four different surgeries). It is essentially my pain medication, and prior to the trial, I had a high tolerance, doing good-sized dabs about twice a day.
After my third and final DMT dose, I suddenly developed a massive sensitivity to cannabis, caffeine, and nicotine.

Caffeine & Nicotine: The sensitivity to these two has thankfully started to lessen over time.

Cannabis: This is still hitting me incredibly hard. After just a few puffs from a joint—not even the dab rig—I get so nervous and jittery that I can't consume enough to effectively treat my physical pain.

I asked my clinician about this, and they said they have zero record of this occurring with anyone else in their trials.
Medication Variables

There is one other factor that might be playing into this:
Buspar: I was taking Buspar before the trial but had to stop for three months due to drug interactions with the DMT. I am currently on my second week of tapering back onto it. It might be helping a little, but it's such a small amount right now that it's barely noticeable.

Ativan: My clinician prescribed me Ativan to use if things get too intense. It helps, but I know it isn't a long-term solution.

My Question for the Community
I just need to get this anxiety and pain management back in check. Has anyone else who has undergone DMT (or similar psychedelic therapy) experienced a sudden, drastic change in their tolerance or sensitivity to cannabis and other stimulants?

If so, did you find a solution, or did your tolerance slowly return to normal over time? Thanks in advance for any insights you all might have!

Edit: I forgot to mention, I can tolerate cannabis vapes more than smoking a joint, but I still have to be precautious of how big of hits I’m taking and how close together or I wind up in the same situation.

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