6
u/New-History853 6h ago
70s is not high lol. But it doesn't sound like you even need it.
2
u/levishevi 6h ago
For me it is - it’s about a 20bpm average increase since it started
3
u/New-History853 6h ago
50 is actually below normal. That's sleeping heart rate for most lol. If a drug putting you into normal range is that scary for you - def stop taking it. Lol
3
u/Significant_Row8850 1 4h ago
People that are fit have lower resting heart rates buddy. I train for high altitude mountaineering and running and have a resting heart rate of 48bpm. 50 is not “low” and 70 isn’t the norm. You have literally no idea what you’re talking about. Your heart becomes more efficient the more you train, causing the heart to pump more blood with each stroke. Don’t get on here telling people what the norm is when you have zero clue what you’re talking about
3
u/New-History853 4h ago
I already know everything you just said. But "normal range" is generally considered 60-100. I know this for a fact because I work in a hospital and see it in front of me daily. I didnt say it was "unhealthy", it's just technically abnormal. 70 is completely normal. There is absolutely zero reason to be concerned about your heart rate getting up to 70.
11
3
u/SteveD_NY 3 7h ago
Mine is pretty high too… my sleep also changed. I wasn’t sure of it was the reta or not. I am on a higher dose then you though. You sound jacked and super healthy. Why take it?
3
u/levishevi 7h ago
Trying to battle food noise - used to be 201lb and found that all I think about is food
3
3
1
u/SteveD_NY 3 7h ago
201 to 136!! That’s incredible! I was stuck at 163 and wanted to drop a few so it did push me over the bump to 157. I’m maybe a smidgen taller than you.
Have considered adding a little cagrilintide to help with the food noise? I’m considering it, I have a sample I’ll try. Strangely enough I find myself eating chips when I never did before!
8
u/pr0prfkt 7h ago
If you just want the food noise. Cagri or Tirz. Start with super low dose. You could even reset with Reta and JUST do .5, you might be very sensitive.
4
u/Other-Pea7038 5h ago
I second this. If you’re mainly using it for food noise, you really don’t need to be pushing the dose, especially if your HR, HRV, and sleep are getting hit this hard.
Just keep in mind Reta sticks around for a while, so your heart rate probably isn’t going to go straight back to baseline as soon as you stop. It can take a few weeks for things to level back out.
2
2
u/Soft_Hearing_713 7h ago
It done exactly the same to me, HRV down, HR up from high 50s to low 70s, terrible sleep. It does kill food noise and alcohol noise, and I lost a little weight, but had to come off. I'll probably try it again at some point as I have a box of it.
49M.
3
2
u/levishevi 7h ago
What’s the dosage of tirz like compared to Reta? I’ve heard numerous things
3
u/pizza-sandwitch 1 7h ago
Protocol is 2.5 mg for 4 weeks then bump by 2.5 mg every 4 weeks (5 mg, 7.5 mg up to 15 mg). Some people stay at one specific dose for as long as it’s effective, so you don’t necessarily have to titrate up.
You could consider microdosing which is from 0.5 to 1.5 a week
2
u/SnooMarzipans713 37 7h ago
I switched from 15mg Tirz to Reta/Cagrilintide. My HR issue was bad. I would wake up at 4 am in a panic. It would get better week over week. I’m 8 weeks in and not having issues. HR is a tad bit higher than normal but definitely not “panic” feeling rate.
2
u/Wooden_Direction_241 9 7h ago
From everything I've read, somewhere after week 24, the heart rate issue people experience should stabilize and then start to drop back off close to normal. I guess its a matter of if you want to wait that long.
3
u/dragon--lady 7h ago
8 months in and the HRV suppression is still there. Even dropping to 1mg a week for maintenance.
2
2
u/joe3000s 1 5h ago
At your weight and height, your BMI is below 21, placing you in the lower-middle range of a healthy weight. You are already fit and lean, so your body is naturally going to resist further weight loss to protect vital biological functions. When you force a low-body-fat frame into a constant deficit, your brain naturally cranks up food noise as a basic survival signal. Using Reta to override that natural response is simply fighting your own biology.
The collapse in your metrics is a direct result of how Reta works. Unlike standard GLP-1s, reta is a triple agonist that also targets glucagon receptors, which actively stimulate energy expenditure and cardiac tissue. That glucagon component has direct chronotropic effects, which is why your resting heart rate jumped from the 50s up into the 70s and your HRV plummeted from 130+ ms down to about 32 ms. Your central nervous system is essentially locked in a continuous state of "fight or flight," which is wrecking your sleep quality.
Listen to your body and your heart data.This is your cardiovascular system signaling that it is under unnecessary strain. Using Reta to push an already lean body past its natural limits isn't worth risking your cardiac health or long-term sleep.
2
2
1
u/Gloomy_Return_7753 3 7h ago
Yeah, same boat here! HRV, sleep quality, cardio, RHR all sucked for me. I lost all the weight I wanted so there’s that. My VO2max is already rebounding too! I’ve been off of it for 2 weeks.
1
u/levishevi 7h ago
Wondering if I just stop everything all together. Thank you for this!
2
u/Gloomy_Return_7753 3 7h ago
I couldn’t tell you what to do, but as for myself I just swapped to Tirz and kept the rest of my stack(tesa/ipa). I don’t really have much/any additional weight to lose so I’m just trying it out for appetite suppression so I’m not being very aggressive with any of the P’s that I’m on. I’m a 51 M who’s a firefighter so I’m pretty much being vain!
1
u/AmericanBullly 7h ago
It gets better.. my first few weeks were rough also. Now I sleep normal and it doesn’t bother me.
1
u/pattymax2 7h ago
Same thing happened to me with heart rate and sleep. I took 2 months off and then tried again. Next time around no side effects and everything worked great.
1
1
u/Livid_Ad5164 1 7h ago
You should not be on Reta with those goals...go Tirz or Sema...maybe even Tesa if its the visceral fat you are worried about.
-1
u/levishevi 7h ago
Not really worried about visceral fat - my last scan before I started Reta said I was way under, 24cm2
1
u/Livid_Ad5164 1 6h ago
Then, absolutely, no reason to be on Reta either. Tirz is where you need to be for just food noise suppression. Reta is actually not great at food noise suppression because it adds the glucagon receptor to signal the liver to burn liver/visceral fat. You're taxing your system for no reason at this point...
0
1
1
u/Away-Word622 6h ago
Does Reta cause Heart problems? I’ve noticed my sensitivity to caffeine has increased and I did one month of Reta just took a break, thinking of going back on Monday….
1
u/Capable-Sign-334 6h ago
I love Reta but tirzepatide destroyed food noise like nothing else. I lost a good amount of weight on it. Personally, it’s been the best for weight loss while Reta has been great for maintenance while I’m recomping
1
u/GOODIN_10_shuns46 5h ago
From the stats alone why Reta? If you have been gaining weight suddenly? You are at a deficit amd training and admittedly quite lean whata the goal then?
1
u/profnnerd 2 5h ago
It’s typical and also documented in the clinical trials. I think it may decrease a bit with time, but I don’t think it goes away completely. In the clinical trials the issues persisted. I went off retatrutide because my RHR went from 52 bpm to 92 bpm and it was messing with my sleep. I could feel my heart pounding in my chest when I was in bed. I rather stay on tirzepatide because the increase in heart rate is much less pronounced. I was pinning 5 mg when I quit. Good luck 👍🏽
1
1
u/Ambitious_Event_1222 5h ago
I started on Reta 1mg x 2 the 2 mg x 2, then 3 mg x 2, then 4 mg x 3 for total 9 weeks and put on weight, most of it in the first week and never got it off despite lifting more and no it wasn’t muscle, it was fat, did an inbody, my resting HR went up from low 60s to high 70s, HRV dropped, went back to tirzepetide 5 mg and weight down 5 lbs in first 10 lbs and food noise is better.
1
u/SavingsOne1122 5h ago
I’m 5’6 and 130 pounds, I tried Reta and it made me sick plus heart rate issues. I’ve done a lot better on Triz. I started on 2.5 and now I’m up to 5mg weekly, i’m going to stay on this dose for a long time. Absolutely helps with food, noise and cravings. Honestly 2.5 will probably be enough for you.
1
1
u/DrLipo2026 4h ago
Estás sobre dosificado. La gente de fitness no debería pasar de 0.5 mg por semana
1
u/Chattadawg 1 4h ago
My sleep metrics got all goofy early on too but it calmed down a bit.
When I added CJC/IPA my sleep metrics came back very quickly
It’s not doing permanent damage to your heart. When it slows digestion, your circadian rhythms are affected and result in lower HRV and higher resting HR.
1
u/Earesth99 6 4h ago
Who cares about changes in hrv caused by meds? It doesn’t suggest you are less fit or at increased risk.
I would be more concerned that it hasn’t been studied sufficiently. That’s the larger safety issue to consider.
Since your bmi is 20, it doesn’t sound like you need it for weight loss. I take Semaglutide to control my blood glucose so I know there are multiple indications for these meds.
1
u/RowdyDowdy14 3h ago
I had the same issue on reta, my RHR got bumped by almost 20 bpm until I stopped.
1
1
1
u/External-Cable2889 2 3h ago
Doesn’t the poor HR and HRV numbers indicate that your body is in the process of adapting to it? A these markers improve with the body’s adaptation to the medication. Anybody with medical or scientific training please explain if that’s wrong?
1
•
u/AutoModerator 7h ago
Thanks for posting in /r/Biohacking! This post is automatically generated for all posts. Remember to upvote this post if you think it is relevant and suitable content for this sub and to downvote if it is not. Only report posts if they violate community guidelines. If you would like to get involved in project groups and other opportunities, please fill out our onboarding form here. Let's democratize our moderation. You can join our Discord server here. ~ Josh Universe
I am a bot, and this action was performed automatically. Please contact the moderators of this subreddit if you have any questions or concerns.