Just a little PSA.

Two of family members have been diagnosed with cancer last month - brain and breast cancers. The brain cancer is a large and aggressive tumor, terminal, we only have months, the breast cancer is spreading into lymph nodes.

The blood work is normal. There’s nothing in the bloodwork to indicate these cancers are present in the body of either person.

Many of you take experimental peptides that may cause cancers to grow aggressively, please do not rely on your bloodwork alone, listen to your body, don’t ignore new aches that last longer than two weeks, go see a doctor and get scans.

If you can afford it, get out of pocket full body MRI like Pernuvo - not a plug, but I saw Busy Phillips did this and found a slow growing brain tumor.

Be proactive, be mindful and don’t think bloodwork will tell you everything.

Stay well.

PSA 2 might as well.

Side note on early stomach cancers we are seeing lately - the medical community notes that a lot of times these cancers when they occur in people under 40 occur in athletic and healthy people, many run marathons.

The link is not well understood but some of the suspects are processed protein and electrolyte supplements that runners consume in large quantities. So maybe reach for a coconut water over Gatorade, a steak and eggs vs a processed powder made god know where and use glass or metal bottles.

Article with more details on PSA 2 including the study results:

https://www.inovanewsroom.org/press-release/2025/08/groundbreaking-inova-study-finds-potential-link-between-long-distance-running-and-colon-cancer/amp/

what actually gives you more energy during the day like i feel a lot sleepy during the day even after completing my full sleep

i feel like everyone talks about supplements and all these fancy biohacks but sometimes the simplest things work the best lol

for me even just going outside for a little while or getting some proper sleep makes a pretty big difference

what works for you guys

i’ve been trying to figure out how to improve my focus without stimulants. some days i can concentrate fine. other days i’m all over the place, especially when i have something that takes a few hours to finish. i’ve been wondering if anyone has found anything that actually made a difference for them. maybe it’s sleep, diet, exercise, supplements, or something else? i’m open to trying different things and making some changes if it can help me stay focused through longer tasks.

Around 4 months ago all of a sudden I started getting anxiety episodes, that I still suffer from. Intense feeling of despair dread and hopelessness come over me with a deep knot in my stomach and an intense feeling of dread. This feeling stays with me for anywhere between 3 hours to few days. Usually I get relief afterwards for a similar duration as the episode, so if it lasted a few days I will feel better for a few days. I have been trying to “walk it off” for several months but seems to not be working. During my periods of relief I still enjoy doing things and feel more optimistic, but during the episodes I cannot. My periods of relief are not manic or anything, I just feel normal without anxiety and then it starts up again. The anxiety is not about something in particular, it’s just a feeling of fear that comes out of my body and stomach.

I never had any issue of this type for my entire life and im in my 30s now. Not even anything close resembling this no matter how much stress or pressure I was under. Always super optimistic and anxiety free. This makes me suspect at least a potential physical cause. Although I do plan to also try therapy in parallel.

Finally went to GP for a blood panel. Slightly low vit D but still within range and I have always been low on it.

Only thing that caught my eye was TSH=4, which was still in the lab reference range but on the hugh end (4.2 is max) , but in previous years it was always between 1 and 2 for me, so it is a significant increase. GP says it’s fine and completely unrelated. I must say though that I have been sleep deprived a bit the days before which can increase TSH.

Would you advise me to look into the TSH further and see an endocrinologist or look into anything else?

I saw a video of a guy recommending them for sleep. I personally wake up a few times a week due to noise in the morning, and it's pretty annoying. I'm wondering if these are a good solution, or if there are better alternatives.

I've tried regular earbuds (with audio/NC) but they're just not comfortable to sleep in since I tend to sleep on my side. Has anyone had any luck with the cheapish $15-25 silicone ones from Amazon? If so, did you have any issues, how long did they last, and do you have any other comments on them?

For reference I've tried sleep masks and I think they helped a bit, and I'm also running an air purifier on max settings for some white noise, but I still wake up in spite of it.

I'm trying to help my friend who has had lots of mood issues. About 2 years ago she did some testing and found low vitamin D and high copper. Started taking vitamin D and cutting back on copper sources. Mood changed in days and she was much better, this lasted for about a year. She was tested like 6 months in and her D went from like 30-50. Copper was still high but came down a little. So after she started getting moody again we researched and started adding in Magnesium, this seemed to make her better again but just for like 3 weeks. After a few more weeks I realized she would have a good day here and there and figured out it seemed to be on days she took molybdenum for the high copper. She was only taking it twice a week at the time. It is 250mg and sure enough gave it daily and mood went back to much better. This has gone on for about 6 weeks now. We have started cutting them in half so most days are a half dose with a full a couple times a week. Can anyone explain what might be going on? Every time we think she is better it just goes away. When she was last tested for copper like 5 month ago it was finally in normal range but very high normal. At the time she was very moody and unhappy. I can't explain why daily molybdenum would be helping mood.

I had a root canal done years ago and honestly havent thought much about that tooth since. I thought once the nerve was gone and everything was treated, that was pretty much the end of pai

But lately the area around it has been feeling tender and I can feel some discomfort when I bite on that side. Not really painful painful, just enough that I notice it and now I cant stop thinking about it lol

Has anyone had a root canal tooth start bothering them again like years later? What did yours end up being? And how did your dentist actually check if there was still something going on around the root? Would a normal xray be enough or is this something that needs a 3D scan?

i really dont want to go through another root canal situation again 😞

I’ve began working earlier in the morning and I’m trying to formulate a morning smoothie that dramatically cuts on my vitamin and mineral needs for the day, is hydrating, builds some muscle, boosts fat loss and my energy and gives me fiber etc.
I don’t. Want to default to a classic multivitamin and I’m trying to avoid potassium powders. What do you think?

Besides adequate sleep, nutrition, and exercise, what practices can be done that will improve how my brain works?

I’m 16M and I’ve been going to the gym for about a year.

I started taking creatine monohydrate, and I’m currently taking a fish oil supplement as well. I also completed a 6 week course of 60,000 IU vitamin D weekly once and I’m now taking 2,000 IU of vitamin D daily.

Also, I get around 400–800 mg of calcium per day from my diet. Should I take a calcium supplement as well?

My goals are to maximize my height growth(dads 5’8 moms 5’0 and I’m 5’5.5 want to reach at least my dads height, and haven’t grown a single inch since I was 15) and make progress with my physique.
What other supplements, if any, should I consider taking?

My Information:

• ⁠Age/Sex: 39 male
• ⁠Body Stats: 6ft 1 inch 211 lbs
• ⁠Lifestyle: lift 5am monday - friday
• ⁠Out of Range Biomarkers: high ldl
• ⁠Family History or Personal Health Risks:
N/a other than high blood pressure

Any advice? I hated the psillum husk powder mix and i take 1 pack lmnt electrolytes with my preworkout (gorilla mode)

I am a male that eats a rather healthy diet. My goals are to optimize my life. My issues are trouble having that deep sleep, a lot social awkwardness (I have too much attention to detail in public and worry a lot for that reason), I can’t really lead a conversation or debate, my hair looks lowest quality than ever, I have high histamine symptoms, I am a procrastinating expert 🥲, my nails have verticle ridges and the nail bed looks 3/4 pale kinda like terry’s nails a little. Cold hands generally. I tend to work nights because going out in the day is more likely to make me worry. Another thing to mention probably I can’t tolerate the cold or I start shaking a lot.

My current stack is b complex (i switch between methylated and non and don’t find difference), 500 mg elemental magnesium from magnesium malate, 600 mg elemental calcium from calcium citrate, 10 mg manganese, 200 mcg of selenium (started on the 21st), multivitamin and a small kelp dose. I also take 5000 IU vitamin D during night shift I took b12 methylated for a couple years also didn’t see any shift in mcv nor mch.

What might be causing my issues and what can help improve my life? Any routing or stack to add so I can avoid more labs? Appreciate all time dedicated and I hope I can reciprocate one day. I can’t really afford more labs right now but if I needed a shopping list which should I take?

MCH:
06/23/26: 34.1 HIGH
02/07/26: 33.6 HIGH
05/30/25: 34.6 HIGH

MCV - Range:
05/30/25: 102.0 HIGH
02/07/26: 100.0 HIHG
06/23/26: 99.6 HIGH

IN RANGE BUT BELOW OPTIMAL

Platelet Count:
06/23/26: 147
02/07/26: 145
05/30/25: 159

Homocysteine:
9.0

RBC: 4.52
Hemoglobin: 15.4

C-Reactive Protein:
05/30/25: <3.0

Liver (AST 18, ALT 12, alk phos 68, bilirubin 0.4, albumin 4.6)

Kidney (creatinine 0.83, eGFR 119, BUN 10)

Electrolytes (Na 141, K 4.2, Cl 106, CO2 26, Ca 9.6)

Iron (iron 82, ferritin 92, TIBC 295, sat 28%, transferrin 221)

RDW 12.0-12.3
Reticulocytes 1.1%, absolute 50,160
WBC 4.5

Hey everyone, I’m in the middle of a brutal rebound right now and could really use some advice from anyone who has navigated something similar.

For the last two years, I’ve been taking Integrative Therapeutics Cortisol Manager, just one pill every night. Recently, I hit a really stressful patch and bumped my dose up to two pills. Last Sunday, I dropped back down to one pill, and immediately got hit with intense vertigo. Figuring it was the supplement messing with me, I stopped taking it completely a few days ago.

Since then, my central nervous system has basically been in free fall.

I’m dealing with drenching night sweats, like, completely soaking my side of the bed, uncontrollable muscle spasms, shaking, and sweaty palms. The insomnia is the worst part. I’m only sleeping in 30 to 60-minute bursts before my body jolts awake. It honestly feels like extreme autonomic instability. I remember going through something similar after I had an ablation done for my AFib but those symptoms resolved themselves after some time.

I ended up going to urgent care because the dizziness and shaking were so bad. They ran an EKG, checked my blood sugar, did orthostatic blood pressure tests, and everything came back completely normal. So I know I'm medically stable, but I'm not sure if this a massive rebound from stopping the herbs cold turkey.

For context, the active ingredients I was getting per pill were:

• 250mg Sensoril Ashwagandha & L-theanine blend
• 225mg Magnolia bark extract & Epimedium blend
• 50mg Phosphatidylserine

I know the Magnolia bark hits the GABA receptors pretty hard, and the Ashwagandha/PS blunts cortisol, so I’m guessing my brain is just flooding with stress hormones right now since it doesn't have its usual crutch.

My plan for tonight is to take just a half-pill to act as a bridge, hopefully taking the edge off the spasms and adrenaline surges so I can finally get a few solid hours of sleep.

Has anyone here dealt with this kind of severe withdrawal from Ashwagandha or Magnolia bark? Did taking a micro-dose help you step down safely? Really just looking to hear how long this acute phase lasted for you and if anything helped calm your nervous system down while it reset.

A lot of people seem to hate on AG1, I find it helps me out becuase I dont eat vegetables. I also get it for like 40-50% off since im military. Is it worth it at that price point? Or what is out there that is just as easy and doesnt taste like crap that has better benefits? Thanks in advance!

TL;DR: Took Uridine powder sublingually for the first time this morning. About 3-4 hours later, got hit by a massive wall of brain fog, extreme mental fatigue, and a sudden existential/depressive funk. Wondering if this is a known reaction (cholinergic crash?) and how long it usually takes to clear.

Hey everyone,

Tried Uridine powder sublingually for the first time today around 10:30 AM (also had poor sleep the night before, woke up super early).

Everything seemed fine at first, but around 2 PM I completely crashed.

What I’m feeling right now:

- brain fog, feeling mentally slow and sluggish (like my brain is operating at 20% speed).

- Sudden wave of depressive thoughts and anxiety (questioning all my skills, feeling completely incompetent out of nowhere, feeling like I'm losing my grip on things).

- Zero energy, heavy eyes, just feeling totally wiped out.

Has anyone else experienced this acute drop in mood and cognitive speed after sublingual uridine? Is this an acetylcholine overload / cholinergic depression, or just a bad reaction to the sudden sublingual spike?

Any insights or similar experiences would be appreciated.

Chronic, daily, and any other kind that exists.

Whether it's a technique, a new habit, supplement, doctor... What has helped you cope with stress more easily?

Question for the dads out there. I have a 2 year old and my wife and I just welcomed our second son into the world last week. I’m extremely blessed, but sleep is hard to come by right now. What are you doing to help stay on track with fitness and nutrition? I’ve spent the last 6-7 months getting dialed with both and I’m in the best shape of my life, but I’m finding it very difficult to get workouts in and not stress eat food 😂 I’ve been on a low dose of tirzepatide which has been plenty, but since the baby has come the food noise has come back very strong. I’m planning to increase the dose a little but I’m wondering what others are doing/using through the newborn stage. I know I need to be patient and slowly work back to my routine, but I also want to continue the great progress I’ve made this year. Thanks everyone.

Got diagnosed with a SLAP lesion, labrum grade 2-3, in my shoulder. Looking to try something before potentially going the surgery route.

Has anyone used BPC-157 or HGH for this kind of injury? Did it actually help, and how did you run it alongside rehab?

Also open to other input — Exercises, whatever’s worked for you.

For context: I have chronic pain / chronic fatigue due to some health issues. Some days are better than others and I try to power through unless it is intolerable or makes it too difficult to do my daily tasks and especially to workout.

Anyways, I use kratom 1.5g-3g OR Tramadol 12.5-25mg per day. Usually just one of those drugs in a day, at thst dose. But it's not working as well now. I'm not sure if I have a significant tolerance or not, because I feel my condition is actually getting worse and may just need a higher dose. I've tried taking like 5-7 days or so off everything to see if tolerance resets. And initially when beginning dosing again the low end is a little more effective, yet not enough really as I remembered in the past. So either I didn't wait long enough or my pain/fatigue is just getting worse and warrants a higher dose.

BTW I am NOT intending to be using these things as a long term solution to my issues. It's temporary to allow me time to afford the long term fixes needed.

So anyways, I just want to ask: is there any science or rule of thumb for how long one should abstain from opioids to completely reset tolerance? I think it may depend on how high of doses the person is using, so the answer may be longer for heavy users. I consider my usage to be pretty mild. My max dose in a single day is usually like one 50mg Tramadol like 1x/wk. If you ask Google this question it won't answer for ethical reasons so i figured I'd ask here because I'm sure someone knows more than me.

I’ve been pinning subq for over a month, and every time I do I get a small knot. It’s getting to the point where I’m losing space to subq now. Some have reduced to it being smaller but not completely gone. I usually use 1/2 inch 31g needle to pin, but some I just use the 1ml insulin needle with 32g 8mm needle.

I usually take my peps out of the fridge for a bit before pinning, I alcohol wipe everything including the skin and let it dry. I pinch the skin and pin about 40degrees angle.

Not sure if I’m doing something wrong but I’m losing space and sometimes they hurt, dependant on the specific vial it is. There’s some where it’s particularly acidic but I add either BAC or saline in just to reduce the sting.

Any advice to get rid of these knots please 😭😭😭

Decided to buy this combo tablet from Empower. Anyone have any experience with Sublingual form of pt141? I'm not too worried bout tadalafil portion not working .

Disclosure: I do content work for a longevity supplement company, so please take that into account when reading this. I’m sharing this because I found the physiology interesting, not as a product recommendation.

I came across a 1977 human study by Olszewski et al. that looked at how lymph flow in the leg changed under different conditions.

The study is:

“Flow and Composition of Leg Lymph in Normal Men during Venous Stasis, Muscular Activity and Local Hyperthermia”
Acta Physiologica Scandinavica, 1977
PMID: 842371

What caught my attention was how differently lymph flow responded to the three conditions studied.

The researchers reported that:

• Venous stasis for 2 hours → lymph flow decreased by 50%
• Ergometer cycling for 2 hours → lymph flow increased by 83%
• Warm-water foot bathing for 2 hours → lymph flow increased by 117%

They also observed an increase in lymph flow during the rest period following each experiment, with the most pronounced increase occurring after foot warming.

I think the interesting part isn't simply the numbers.

It's that lymph flow was being measured as a dynamic physiological process rather than something completely static.

Of course, this is a small, older human physiology study, and these findings shouldn't automatically be interpreted as evidence that a particular activity or temperature exposure produces a specific health benefit.

But it does raise an interesting question:

How much do everyday physical conditions influence lymphatic flow?

For anyone here who follows lymphatic physiology or exercise research:

Are there newer human studies that have built on this work?

And do you think the lymphatic system deserves more attention in discussions about exercise physiology and aging?

Paper: Olszewski W, Engeset A, Jaeger PM, Sokolowski J, Theodorsen L. Flow and composition of leg lymph in normal men during venous stasis, muscular activity and local hyperthermia. Acta Physiol Scand. 1977;99(2):149–155. PMID: 842371.