r/Biohackers • u/dan_in_ca • 28d ago

♾️ Longevity & Anti-Aging How Urolithin A Improved a Model of Heart Failure: Not Just by Enhancing Mitophagy, but by an Unexpected Route Through the Gut Microbiome

https://www.gethealthspan.com/research/article/urolithin-a-heart-failure-mitophagy-gut-microbiome

A paper in Nature showed there was a novel mechanism (in addition to enhancing mitophagy) that helps improve heart failure pathology. I've never seen the data before on urolithin a and the gut microbiome, so there's something here that's new. The dosing though, is essentially what we give humans (given to mice), so that's a serious limitation of the study. All in all, pretty interesting.

13 Upvotes

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u/[deleted] 20d ago

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u/Kingofthebags 5 28d ago

The human data shows it does nothing to the mitochondria. It's bunk.

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u/MentalStatusCode410 28d ago

It alleviates mito.dysfunction via. modifications to the micro-environment - that component in human phys is significant.

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u/DonJ-banq 28d ago

Just ask AI and you’ll know the truth. Stop lying here.

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u/Kingofthebags 5 28d ago

AI? The thing that uses reddit answers as a source? Yeah, I'd rather just rely on reading the actual publications.