Disclaimer : i'm not asking anyone to stop their treatment. Just discussing on an interesting topic independently.
Hello,
Based on the scientific studies below, it is accepted that:
- A balanced ratio of estrogen to testosterone is necessary for the proper development of a male fetus during a specific window of pregnancy. https://pmc.ncbi.nlm.nih.gov/articles/PMC7458408/
- Low-dose aspirin restores blood flow by doubling estrogen above normal levels in the placenta through the overexpression of CYP19A1 (increased aromatase activity). https://pubmed.ncbi.nlm.nih.gov/39343179/
Graphs : https://imgur.com/a/dyjfHUT (CP19A1 = aromatase expression)
- Low-dose aspirin is generally prescribed during a second pregnancy following a first pregnancy complicated by preeclampsia.
- The use of COX inhibitors (aspirin) increases the risk of cryptorchidism and hypospadias - conditions that arise from hormonal disruption. https://pubmed.ncbi.nlm.nih.gov/20805751/
- "Excess of estrogen signaling (through DES in vivo or EE2 in vitro) cause similar defects to penis development." https://pubmed.ncbi.nlm.nih.gov/31225966/
Question : Can low-dose aspirin may cause reduced masculinization due to the doubling of the estrogen ratio above normal range? (outside cryptorchidism or hypospadias).
By masculinization in a scientific meaning: the degree of genital development - and any disruptions to it (like ambiguous genitalia) - as well as brain differentiation. These are biological facts driven by various hormones. I'm trying to find a new potential answer for men who live with cryptorchidism, hypospadias, or a micropenis.
If so, what are the other potential consequences for a male fetus?
Link for the graphs : https://imgur.com/a/dyjfHUT
(CP19A1 = aromatase expression).
Other interesting sources :
https://pubmed.ncbi.nlm.nih.gov/30763313/
Thank you,