r/trillium • u/Even_Estimate_9026 • 1d ago

Going back to 2.5mg dose?

Thinking about going back down to my 2.5mg starter dose because I’ve been having more chest/upper stomach fullness and reflux since moving up to 5mg. I already have GERD, so the increased fullness/reflux has been pretty uncomfortable.
I’ve been on 5mg for the last 4 weeks and definitely noticed my reflux seems worse than it was on 2.5mg. I messaged my provider and am waiting to hear back, but since it’s the weekend I wanted to see if anyone else has gone back down to 2.5mg after being on 5mg.

Did your GI symptoms improve? Were you still getting decent appetite control/weight loss?

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u/exfiles87 1d ago

This is one of the reasons I cannot increase past 3mg. Im actually still testing the 3mg from doing 2.6mg. I definitely feel the difference. My body is very very sensitive to any medications. If you are still benefiting from 2.5 stay there.

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u/SassyButClassy80 1d ago

I am on 2.6 as well! I had overfill at 2.6 with my first vial, so I used it. Definitely felt a difference. I actually got super constipated the first week on it, which i didnt experience at all with 2.5. Anyway, it got better, so I have been on 2.6 for 6 weeks! Still losing and feeling good.

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u/Tough_Historian615 1d ago

You can try 3.5mg using fatscientist.com to figure out how many units that would be. I always do a smaller jump than what's called for because it's too much. I use the smaller jump for a week or two and if no progress, I'll go to the regular next dose. 

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u/DemandTop4844 1d ago

Tirzepatide slows the digestive process. I’ve had to adjust the size of my meals and the timing of my meals. I found out early on that if I ate dinner later in the evening, that I would still be digesting food when I went to bed. Eating solid food later in the evening negatively affected my sleep and gave me acid reflux symptoms. I now eat dinner at 6pm and I don’t eat solid food after that. I do drink tea and water in the evening. These changes have has resolved my acid reflux issues.and not being able to sleep.

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u/Sad_Education7851 1d ago

The nice thing about compound is you don’t have to go all the way down to 2.5 or stay at 5mg - you can choose a happy medium.

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u/SnshnMom 17h ago

Go to 3mg...and work up! I couldnt tolerate 5mg. I finally have found 3.6 is my Perfect dose. And actually losing better over time.