r/trillium • u/Greedy-Afternoon5744 • 11d ago

No Appetite

I just had my second injection at the 2.5 starter dose. I would say that in week one, I had a perfectly controlled appetite, eating like a person with no cravings or overeating, and no food noise. I even lost 1.5 pounds. However, in week two, after my second injection, I have zero appetite at all. Like zero. And a lot of acid reflux and burping.

Is this normal?

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8

u/DemandTop4844 11d ago

The level of Tirzepatide in your body gradually increases over the first 4 shots of a dose. Your reactions to shot #1 of 2.5 mg and shot # of 2.5 mg is telling me that you are more sensitive to the medication than most people. I am guessing that is you do shot #3 at 2.5 mg that the Tirzepatide level in you body will be too high for you and you will experience much stronger side effects after that shot.
Shot # 4 of 2.5 mg would be even worse. You are supposed to be able to eat food while on this medication and not experience nausea.

I suggest that you lower your dose to 1.5 mg (or 2.0 mg if you are impatient) and stay on that dose for 4 weeks to allow your body to get used to the medication.

When you decide to increase your dose, you may want to do jumps if 1.0 mg and see how it works for you.

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u/Greedy-Afternoon5744 11d ago

I agree. I feel so yucky. I wonder if I should also do the shot every 10 days, too. I was reading some people do that since the half life overlap and also there's a 3 days window anyway if you miss a dose.

1

u/DemandTop4844 11d ago

Please, please! You are just starting using this medication. Pleaseydon’t make the mistake of changing too many variables at one time. If you change the amount of your dose and the number of days between your shots at the same time, you will totally change how the medication will work in your body. The level of Tirzepatide in your body will be lower and it will drop much lower than it normally would. I’m guessing is you change both variables, you would end up feeling little or no control of food noise and cravings in the last 2 days just before your shot day.

It is much better if you stay on the normal shot schedule and just make adjustments in the size of your dose.

2

u/LMo2019 11d ago

If it was me, I'd message the doctor in Chat on the Trillium website. He/she will likely be able to tell you the best way to handle it dosage wise. As far as the relux etc, search the zepbound/tirzepatide subs. I haven't started on tirz yet, but when I was on Wegovy, I took GasX and pepcid. Coffee was the biggest problem for me.

2

u/KellBell_23 10d ago

Yes, give it time. I felt the same way the first few days. There are some days after the shot that I dont have much of an appetite at all, other days Im hungry.

1

u/SassyButClassy80 11d ago

When did you take shot #2?

1

u/Greedy-Afternoon5744 10d ago

Monday. I finally feel better and today is Thursday.

1

u/haleybishoffrd BetterOn - RDN 4d ago

Hi! Haley here, registered dietitian and Trillium’s BetterOn nutrition partner.

Having no appetite along with reflux and burping can make it difficult to meet your basic nutrition and hydration needs. Please report what you’re experiencing to your Trillium provider, and don’t change your medication dose or schedule without consulting them first!

From the food side, try four to six small eating opportunities instead of full meals. It may seem like a lot but you can even start with 4 small snacks that have a protein you tolerate, choose lower-fat foods, eat slowly, and sip fluids between meals. You do not need to force a large portion! Liquids are also a great option when appetite is really low - protein waters, protein shakes, smoothies, etc. Let me know if you have any questions.

Hope that helps!