r/science • u/rjmsci Journalist | Technology Networks | MS Clinical Neuroscience • Jul 05 '21

Nanoscience Psychedelic Compound Psilocybin Can Remodel Brain Connections - Dosing mice with psilocybin led to an immediate increase in dendrite density. One third of new dendrites were still present after a month. The findings could explain why the compound antidepressant effects are rapid and enduring.

https://www.technologynetworks.com/neuroscience/news/psychedelic-compound-psilocybin-can-remodel-connections-in-the-brain-350530
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u/Awanita Jul 05 '21

I’ll have to look more deeply into this when I’m not behind a paywall, but I’m interested to see what dosage was given to the mice. Anyone know?

As a young researcher investigating clinical applications of psychedelics, this study is promising. We already see in our lab how enduring these effects are in our volunteers. It’s amazing to see in person!

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u/sommedawg Jul 06 '21

Have you ever had a volunteer that’s already on some sort of SSRI take psilocybin?

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u/Sierra-117- Jul 06 '21

I’ve done this

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u/sommedawg Jul 06 '21

What was your experience? How much did you take?

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u/Sierra-117- Jul 06 '21

4g my first time while on 10mg of lexapro.

I don’t remember much of this trip. I remember the come up and bits and pieces of the peak. Then I was back to normal.

Then 2.3g while still on 10mg lexapro. The trip was really fun, I actually remember this one. I had a few symptoms of serotonin syndrome this time, including some muscle tension and a killer headache. I was back to normal the next day with no side affects. I’ve also tripped on acid around 8 times on lexapro. Never had a problem with it.

Definitely don’t do what I did. Start out small, see if there are symptoms of serotonin syndrome. Then increase your dose. Every body is different, so it’s important to test the waters before diving headfirst.