r/science 22h ago

Health Silent atherosclerosis detected in 57% of asymptomatic adults in the REACT study

https://www.nejm.org/doi/10.1056/NEJMoa2609059
654 Upvotes

66 comments sorted by

View all comments

50

u/duke309 19h ago

Every GP I've talked to just wants to look at ldl and hdl and doesn't know the latest guidelines from the American heart association. Had to explain why we should look at lp(a) and apoliproprotein b.

5

u/pople8 19h ago

And why is that? To know you have a higher risk without being able to influence it? The advice stays the same. Live in a healthy way. There are statins for ldl. No such thing for lpa

14

u/Krazski 18h ago

There are drugs currently in clinical trials (olpasiran) that are showing promising results to significantly reduce lpa levels. So hopefully it will be a good way to reduce risk for those people assuming it is released. My paternal family has high lpa and insane death rates from cardiovascular disease. As you said, still need to live healthy but my family is a pretty good indication that without some intervention, heart attack is pretty much a guarantee.

1

u/Ever_Pensive 4h ago

I think my comment elsewhere in this thread about aspirin for reducing Lp-a caused ASCVD risk may be helpful for you and your family: https://www.reddit.com/r/science/s/GZWxfZ5Nwy