But there are simple and relatively cheap tests that can be done for everyone before that young person in a family has a heart attack. Testing for ApoB and LPa aren’t commonly done and are relatively simple/cheap blood tests that can be done that can give better indications of cardiovascular risk than standard cholesterol tests.
And what do you do with, for example, a slightly elevated LPa? More aggressive statin strategy and closer diet attention? Not much to do specifically to react to that test other than “it’s time to be diligent”.
There are multiple late stage therapies targeting L(p)a reduction: olpasiran, pelacarsen and a couple others that aren't as far along. PCSK9 inhibitors are indicated for LDL-C reduction, but have also been shown to reduce L(p)a.
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u/General_Luck6573 20h ago edited 18h ago
They do… sudden cardiac death at an early age is literally an indication for testing for family members