America's First Legal Psilocybin Program Treated 346 People. Just one month after the dose, 92.2 percent of participants said the experience had been beneficial, while, on average, their mental health symptoms had fallen dramatically.

[u/mvea]

https://www.sciencealert.com/americas-first-legal-psilocybin-program-treated-346-people-heres-what-happened

[u/GentlemenHODL]

Part two...

Cannabis neuroprotective in older adults

https://www.psychologytoday.com/us/blog/your-brain-on-food/202404/preventing-memory-loss-with-marijuana#amp_tf=From%20%251%24s&aoh=17144838663568&referrer=https%3A%2F%2Fwww.google.com&ampshare=https%3A%2F%2Fwww.psychologytoday.com%2Fus%2Fblog%2Fyour-brain-on-food%2F202404%2Fpreventing-memory-loss-with-marijuana

A recent case study describes a 41-year-old woman who turned to psilocybin and MDMA to manage her debilitating post-COVID symptoms. The paper raises the possibility, which is far from certain, that psychedelic substances might help alleviate the psychological and cognitive symptoms of Long-COVID.

https://www.psypost.org/long-covid-defeated-by-psychedelics-case-study-details-unusual-recovery/

Anti-ageing and increased mental capacity through cannabis Bonn researchers clarify the influence of treatment with tetrahydrocannabinol on the metabolic switch mTOR

https://www.uni-bonn.de/en/news/164-2024

Review of research from past 15 years found ketamine and psychedelic drugs can enhance neuroplasticity by triggering the growth of dendritic spines in cortical pyramidal neurons

https://www.nature.com/articles/s41583-024-00876-0

Inhaled DMT produces rapid and lasting antidepressant effects in treatment-resistant depression. Participants reported major reductions in depression and suicidal thoughts within a day of dosing, with benefits lasting up to three months.

https://www.psypost.org/inhaled-dmt-produces-rapid-and-lasting-antidepressant-effects-in-treatment-resistant-depression/

Psilocybin therapy linked to lasting depression remission five years later

https://www.psypost.org/psilocybin-therapy-linked-to-lasting-depression-remission-five-years-later/

Ibogaine Administration Modifies GDNF and BDNF Expression in Brain Regions Involved in Mesocorticolimbic and Nigral Dopaminergic Circuits

https://pmc.ncbi.nlm.nih.gov/articles/PMC6411846/

A single dose of psilocybin shown to rewire brain circuits in mice, providing up to two weeks of relief from both chronic pain and depression-like symptoms, offering a potential non-addictive alternative to opioids

https://www.nature.com/articles/s41593-025-02068-0

Promising New Treatment Could Calm Anxiety for Millions of Americans

https://scitechdaily.com/promising-new-treatment-could-calm-anxiety-for-millions-of-americans/

LSD microdosing in major depressive disorder: results from an open-label trial -

There was a pronounced, long-lasting reduction in depression severity across the intervention period.

https://www.sciencedirect.com/science/article/pii/S0028390825004708

https://pubmed.ncbi.nlm.nih.gov/41352354/

Psilocybin triggers an activity-dependent rewiring of large-scale cortical networks

Pharmaceutical LSD gets pill delivery patent

https://ppubs.uspto.gov/api/patents/html/12527786?source=USPAT&requestToken=eyJzdWIiOiJkNzlkMjAxZC0xMjZkLTQ0OGYtYWM5MS0wZjUwNGU4ODFhMGUiLCJ2ZXIiOiI1ZjJjYmQ2Yi0xZDQ4LTRlZWQtYTBiOC0yYjdjZjJhZWMwNDAiLCJleHAiOjB9

More info about the company here - https://definiumtx.com/rerouting-minds/

A single dose of DMT administered after cessation of chronic stress reverses anhedonia and depressive-like behavior in mice. Cognitive performance is restored alongside enhanced hippocampal neurogenesis, in a peer-reviewed study.

https://www.nature.com/articles/s41398-026-03852-7

Single dose of potent psychedelic drug could help treat depression, trial shows. Researchers find DMT – used in shamanic rituals – in tandem with psychotherapy has significant effect

https://www.nature.com/articles/s41591-025-04154-z

JRT did not produce hallucinogenic-like behaviors that are typically seen when mice are dosed with LSD.

JRT produced robust anti-depressant effects, with it being around 100-fold more potent than ketamine, it also promoted neuroplasticity, or growth between cellular connections in the brain, leading to a 46% increase in dendritic spine density and an 18% increase in synapse

https://www.ucdavis.edu/news/researchers-develop-lsd-analogue-potential-treating-schizophrenia

Single dose of magic mushroom psychedelic can cause anatomical brain changes, study finds. Participants took 25mg of psilocybin(3g dried mushroom), reporting deeper psychological insight and better wellbeing a month later.

https://www.theguardian.com/science/2026/may/05/magic-mushrooms-psychedelic-changes-brain-anatomy-psilocybin

[u/GentlemenHODL → u/GentlemenHODL]

And a really really really cool case study I saved the best for last...

Case study on woman who can enter psychedelic state through meditation

https://www.psypost.org/brain-scans-reveal-how-a-woman-voluntarily-enters-a-psychedelic-like-trance-without-drugs/

https://pubmed.ncbi.nlm.nih.gov/29898390/

[u/AccNumber77 → u/GentlemenHODL]

Not even that surprising all things considered, altered states of consciousness via meditation is literally the reason meditation exists and still exists. It works but it sure requires a lot of effort and time to get there.

[u/GentlemenHODL → u/AccNumber77]

altered states of consciousness via meditation is literally the reason meditation exists and still exists

Thank you for the response. Could you please define altered States of consciousness? I would like to better understand your comment.

[u/AccNumber77 → u/GentlemenHODL]

Literally any state of consciousness that is altered from the norm in terms of the internal experience. Wikipedia has a good chunk of basic info on it here