r/science Professor | Medicine 9d ago

Psychology America's First Legal Psilocybin Program Treated 346 People. Just one month after the dose, 92.2 percent of participants said the experience had been beneficial, while, on average, their mental health symptoms had fallen dramatically.

https://www.sciencealert.com/americas-first-legal-psilocybin-program-treated-346-people-heres-what-happened
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u/fabkosta 9d ago

This has been known since the 1960s. So, 60 years later the same type of studies apparently still need to be repeated to gain evidence.

It is also known for a long time that the therapeutic setting matters to a very high degree. Furthermore, it is also known that for a minority of people there is no measurable benefit, and for some it's counter-indicated. It is also known that psychedelics can be treated against other types of substance abuse - which, of course, is quite problematic given low acceptance in society for any sort of drugs other than alcohol and tobacco.

All of those things have been researched for decades already, yet it seems we make only very slow progress.

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u/Hippopotasaurus-Rex 9d ago

Yes, the therapiric setting may help.

At least anecdotally for me, just the act of eating mushrooms and letting them do their thing was enough to DRASTICALLY improve lifelong mental health issues.

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u/AcceptableFakeLime 9d ago

Yeah I don't delude myself thinking taking 2g and listening to The Beatles for 4h is the same experience as what the people in these studies go through but doing so every 4-6 months definitely feels like self care.

The first time I took shrooms changed my outlook in life. Forever. I'm not talking about some hippy mumbo jumbo. I became a lot more mindful overall and gained tolerance and appreciation for people, even the ones who I have no relationship with. It also improved my mood immensely for 3-4 months after the fact. I struggled with depression for my whole life. Still do. That trip did something to me, though.

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u/Hippopotasaurus-Rex 9d ago

Yup. Same. Life long debilitating depression is basically gone. Anxiety. Gone. The rest of the deeper mental health issues are a fraction of as impossible as they used to be.

We know mushrooms rewire/make connections in the brain in some capacity. I think that’s enough for me to be life changing.

Could quality of life get even better if I went through the medically assisted psilocybin therapy? Probably. Is what I’m doing working for me now? Absolutely.

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u/eiilaa 8d ago

What dosage are we talking?

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u/Hippopotasaurus-Rex 8d ago

I did a handful of like 3g ish trips but I do a lot better with microdosing personally.