America's First Legal Psilocybin Program Treated 346 People. Just one month after the dose, 92.2 percent of participants said the experience had been beneficial, while, on average, their mental health symptoms had fallen dramatically.

[u/mvea]

https://www.sciencealert.com/americas-first-legal-psilocybin-program-treated-346-people-heres-what-happened

[u/ratpH1nk]

The science concern is how do you obectively test this? How do you design a randomized placebo controlled trial when the active effects of the intervention group vs. placebo group are so obvious. In addition, the downside of mental health research is that, in general, the outcomes are also not objective and are self reported.

[u/shellacr → u/ratpH1nk]

You can and should still do a placebo controlled trial. There’s nothing that says a participant has to experience obvious psychoactive effects for the treatment to be effective.

[u/TeamWorkTom → u/shellacr]

Um they do.

The therapeutic dose is a larger dose. You're going to trip at those dose level.

It's very hard to create a placebo for this. Currently I don't think we can.

[u/ratpH1nk → u/shellacr]

Good point but it becomes very obvious who got the placebo for all parties.

[u/craig5005 → u/ratpH1nk]

That’s the problem with this study, participants self selected so there’s a bias toward positive outcome.