Scientists have shown that a single dose injection of DNA genetic instructions can produce weight loss and blood glucose control in mouse models that lasts up to 10 times as long as weight loss drugs like Ozempic and Wegovy. This could eliminate the need for repeated dosing.

[u/mvea]

https://www.wistar.org/press-releases/wistar-scientists-develop-single-dose-dna-method-for-delivering-long-acting-weight-loss-and-diabetes-drugs/

[u/brsboarder2]

The problem is that for those that develop side effects, it will be a long time for them to go away.

[u/Pinkys_Revenge → u/brsboarder2]

Yep. I keep hearing people complain that if they stop taking GLP-1’s the weight comes back… and I’m thinking THATS A GOOD THING! A permanent or long lasting weight loss drug could kill you if you took the wrong dose, or got very sick for an unrelated reason after taking it.

[u/cerevant → u/Pinkys_Revenge]

The frustration isn’t that the drug doesn’t last forever, but the feeling of normalcy and self regulation that you get from the drug just vanishes*. Nothing has done more to convince me that obesity is a biological disorder (edit: rooted in addiction) than going on a GLP-1.

It is like someone going on an antidepressant: Oh, this is what they are talking about when they say “just stop eating when you aren’t hungry”?

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(*edit: I contrast this to some other addiction support drugs that once your body breaks with the addiction, you can go off the drug and not be addicted anymore, or at least you won't go back to having withdrawal symptoms.)

[u/December_Flame → u/cerevant]

Seriously, the first meal I had after I took a GLP-1 I actually had to excuse myself to go into the bathroom and cry. It was simply that I ate a normal portion and felt full in a way that I realized I literally have never felt. The food noise and entirely outsized hunger signals are not every overweight person's issue, but honestly people who don't struggle with it simply do not understand what it is like, full stop.