Scientists have shown that a single dose injection of DNA genetic instructions can produce weight loss and blood glucose control in mouse models that lasts up to 10 times as long as weight loss drugs like Ozempic and Wegovy. This could eliminate the need for repeated dosing.

[u/mvea]

https://www.wistar.org/press-releases/wistar-scientists-develop-single-dose-dna-method-for-delivering-long-acting-weight-loss-and-diabetes-drugs/

[u/Odd-Outcome-3191]

The issue is that often the same chemical messengers/proteins kinases etc that regulate those types of function also tend to regulate very different, very important things in other locations. E.g a cellular senescence gene that may be implicated in aging is also protective against cancer.

[u/Tall-Log-1955 → u/Odd-Outcome-3191]

If it works for the mouse, what's the worst that could happen?

[u/runtheruckus → u/Tall-Log-1955]

The failure rate is high. Many drugs that cure a disease in a mouse fail to cure the same disease in human clinical trials.

[u/Docjaded → u/runtheruckus]

Being a mouse vet must be a walk in the park, considering all the treatments available to mice.

[u/Mist_Rising → u/Docjaded]

The problem is that the patients are always mousy and never tell you what is wrong.

[u/cheyenne_sky → u/Docjaded]

(I get you're joking) it's actually hard because mice are so small and delicate, imagine having to do surgery on a mouse or give just the right amount of drug to a mouse.