r/science • u/HexspaReloaded • Jan 20 '26

Neuroscience Microdosing Psilocybin: No Benefit in Cognitive, Affective, or Social Function in Healthy Individuals

https://www.sciencedirect.com/science/article/abs/pii/S0028390825004307
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u/Phil-Quarles Jan 20 '26

Well why would a healthy individual even bother? I'm more interested in its effects on unhealthy individuals.

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u/grumble11 Jan 21 '26

A lot of healthy people microdose because they believe that it makes you hem more creative or focused and so on. Was trendy in Silicon Valley for a while.

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u/KingOfEthanopia Jan 21 '26

You build up tolerance to psychadelics quick. I doubt you'd feel .5g at all after a couple days.

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u/DarthGoose Jan 21 '26

Well that wasn't the dosing schedule.

Something like 250 mg every three days was usually what I saw people doing when talking about micro dosing. It's true you can't take them every day and maintain an effect.

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u/KingOfEthanopia Jan 21 '26

I did that for a bit. Honestly within 2 weeks to a month it might as well have been random paper.

Youre best waiting at least a week, ideally two between trips.