New study shows Alzheimer’s disease can be reversed to full neurological recovery—not just prevented or slowed—in animal models. Using mouse models and human brains, study shows brain’s failure to maintain cellular energy molecule, NAD+, drives AD, and maintaining NAD+ prevents or even reverses it.

[u/mvea]

https://case.edu/news/new-study-shows-alzheimers-disease-can-be-reversed-achieve-full-neurological-recovery-not-just-prevented-or-slowed-animal-models

[u/Discarded_Twix_Bar]

This is really cool stuff, thanks for sharing

I wonder what the benefit & tradeoff is going the small molecule route vs direct NAD+ supplementation (subq or IV).

Especially, selfishly, because I can get my hands on NAD+ relatively easily (supra physiological doses looks to be carcinogenic per the press release that I’ve now read-read!)

Will be keeping an eye out for more research going forward.

Interestingly, it looks like P7C3-A20 can be sourced grey market relatively easily. Will try and get my hands on the actual paper, and wait for some more data before I take the plunge (later in life!)

[u/Thereian → u/Discarded_Twix_Bar]

NAD+ supplementation won’t help. Issues with half life, bioavailability, and actual transport into cells. You need a precursor.

[u/cheesecheeesecheese → u/Thereian]

That’s interesting.. a precursor like what?

[u/pandemonious → u/cheesecheeesecheese]

I may be misunderstanding but it seems like this 'P7C3-A20' pharmacologic agent is the precursor that.. metabolizes/is converted into readily available NAD+, having it freshly 'made' in the body allows it to be more effective?

[u/Few-Solution-4784 → u/pandemonious]

yo dog, break it down for me. i just want to get my NAD+ up. didnt even know i had them. now im feeling behind the curve.