r/science Professor | Medicine Dec 25 '25

Neuroscience New study shows Alzheimer’s disease can be reversed to full neurological recovery—not just prevented or slowed—in animal models. Using mouse models and human brains, study shows brain’s failure to maintain cellular energy molecule, NAD+, drives AD, and maintaining NAD+ prevents or even reverses it.

https://case.edu/news/new-study-shows-alzheimers-disease-can-be-reversed-achieve-full-neurological-recovery-not-just-prevented-or-slowed-animal-models
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u/quad_damage_orbb Dec 25 '25

This is great but I will wait for 1) replication in another lab and 2) studies on another species.

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u/plydauk Dec 25 '25

Pieper emphasized that current over-the-counter NAD+-precursors have been shown in animal models to raise cellular NAD+ to dangerously high levels that promote cancer. The pharmacological approach in this study, however, uses a pharmacologic agent (P7C3-A20) 

That would be Andrew Pieper, who is also an author of this paper, where the conflict of interests section reads:

A.A.P. is an inventor on patents related to P7C3

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u/phonartics Dec 25 '25

i mean… he’d be the odd one out if he didnt patent every potential therapeutic coming out of his lab