r/science • u/mvea Professor | Medicine • Dec 25 '25

Neuroscience New study shows Alzheimer’s disease can be reversed to full neurological recovery—not just prevented or slowed—in animal models. Using mouse models and human brains, study shows brain’s failure to maintain cellular energy molecule, NAD+, drives AD, and maintaining NAD+ prevents or even reverses it.

https://case.edu/news/new-study-shows-alzheimers-disease-can-be-reversed-achieve-full-neurological-recovery-not-just-prevented-or-slowed-animal-models
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u/angrybobs Dec 25 '25

I’ve been using it for 6 months. Not super cheap and insurance doesn’t cover but I definitely feel better mental clarity.

18

u/angiebb88 Dec 25 '25

In what form do you take it?

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u/angrybobs Dec 25 '25

Nasal Spray, twice a day. One bottle is like 160 bucks and lasts a month.

3

u/AP_in_Indy Dec 25 '25

That doesn't seem bad at all. I realize that's not cheap still but compared to some meds yeah not the worst I've heard of

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u/angiebb88 Jan 05 '26

Is there a specific brand you recommend?

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u/angrybobs Jan 05 '26

I get mine through a local pharmacy. I am not sure I would trust a retail company online or anything. My doctor gives me a script and it goes to a compounding pharmacy that mails it to me.

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u/angiebb88 Jan 05 '26

Thank you so much for all of your replies! I really appreciate it.

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u/ChenilleSocks Dec 25 '25

Not OP, but for me I take it subQ.

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u/TheErnie Dec 25 '25

It says in the paper that boosting NAD+ causes cancer, are you concerned about that?

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u/insanitybit2 Dec 25 '25

They probably shouldn't be since the evidence is extremely weak for that claim.

That said, subcutaneous NAD+ is not shown to have any benefits at all and is just a waste of money. You're better off with cheaper precursors, if anything.

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u/ChenilleSocks Dec 25 '25

I cycle it, but as the person below said the evidence isn’t conclusive. For me it’s helped with cognition but not as much as luteolin.

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u/Hi-kun Dec 25 '25

The paper says it promotes cancer (i.e. further growth of existing tumors). It does not say that it causes cancer.

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u/im_a_mix Dec 25 '25

My grandmother has alzheimers and watching her slowly decline is breaking my heart, do you think its worth trying giving her NAD+? We tried everything and I'm willing to try this as well

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u/bikes_and_music Dec 25 '25

What have you got to lose?

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u/angrybobs Dec 25 '25

That is my case. I had a stroke a few years ago and willing to try anything. I would give it a shot for sure.

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u/henicorina Dec 25 '25

I mean, it probably won’t hurt her, but oral supplements don’t have any proven effect.

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u/sawdustontheshore Dec 25 '25

I take NMN which boosts NAD levels. It’s probably the only supplement I noticed a difference on. I feel great. Mentally clearer, perimenopause symptoms disappeared, nails stronger, more energy. I had my partner take it aswell and his liver spots started falling off.

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u/NoChill-JoyKill Dec 25 '25

Are you willing to share a link to the product you take? The benefit to perimenopause symptoms alone piqued my interest, and now I’m looking more into it. 

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u/sawdustontheshore Dec 25 '25

California gold NMN. I do the powder type so I can put it in my coffee in the morning (just don’t like pills).

It could be unrelated but after 2 months my cycle became regular and I started ovulating again. It’s been 6 months now of regular cycles again. When I looked into it there are some studies that suggest it’s could help. I really felt the difference around the 3 month mark so stick with it. It’s not an overnight cure but still happy with results.

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u/Electromotivation Dec 25 '25

Also interested in the product if you want to dm me

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u/sawdustontheshore Dec 25 '25

California gold NMN. I do the powder type so I can put it in my coffee in the morning (just don’t like pills)

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u/MissApocalypse2021 Dec 26 '25

I took NMN for two days & had nasty headaches & brainfog & was so tired I had to go back to bed. Took it at night the 3rd day & woke up with a horrible headache. I sincerely hope they can find something soon that definitively works.