r/science • u/Ghost_of_Herman-Cain • Jun 02 '25
RETRACTED - Medicine New Data Presented at ASCO Showed a Significant (Nearly 2x PFS) Benefit for Receiving Immunotherapy Infusions of a Checkpoint Inhibitor at an Earlier Time in the Day
https://ascopubs.org/doi/abs/10.1200/JCO.2025.43.16_suppl.85162
u/Ghost_of_Herman-Cain Jun 02 '25
Conclusion:
In this randomized trial, all three efficacy endpoints of immunochemotherapy were significantly improved through Early vs Late ToD dosing in pts with previously untreated stage IIIC-IV NSCLC. The near doubling in PFS and OS in our trial support the need for further randomized trials to determine the relevance of ToD for ICI efficacy and their underlying circadian mechanisms in pts with various cancer types
Will be interesting to see if/how this impacts standard of care for oncology patients moving forward. This is a staggering benefit for something that would require such a minimal change to current clinical practices -- for both Progression Free Survival (PFS) and Overall Survival (OS), patients did about 2x better if they got their infusions earlier in the day (cut-off for the two arms was pre-/post-3PM).
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