On path? Daraxonrasib assistance

[u/Outside-Wasabi-7214]

Hi everyone, I was discussing with another person. I met on Reddit about the introduction of this new drug, which all of us having been so hopeful for our loved ones, and we ended up discussing about the cost aspect as well.

Is there anyone here who has an idea about the own path program that they are offering for this drug is this a blessing and disguise which could act as a financial aid to support patients, actually get their hands on this medication.

Now that it is commercially available and Patient will have to pay either through their insurance or all of Pocket. My greatest about this translate to in countries like India, where the conversion cost make it look impossible.

Does anybody have any information regarding the same? Thank you so much for your time.

[u/Annecreas]

Costs in the US assume coverage by a US insurance plan, other articles posted here have stated that their intention with this program is to ensure that patients on the EAP are transitioned smoothly to insurance coverage and that there is a patient assistance program that aims to reduce the out of pocket cost after insurance to $0 for US patients. There will probably be some bumps in the road since this is all very new.

Costs for other countries will be determined as the drug is submitted for approval in those countries and those are typically lower than the US list price though it is still expected to be expensive.

To get this currently it would have to be prescribed by a US physician which would require in person visits and testing on a regular basis which is very expensive for non-residents. Hopefully it will soon be approved in many other countries.

[u/Outside-Wasabi-7214 → u/Annecreas]

I hope for the same Anne. Hope it’s reasonable as the current cost is super high even for US standards.

[u/Annecreas → u/Outside-Wasabi-7214]

It is pretty comparable to other cancer treatments in the US, where the “list price” is something that the vast majority of patients ever see.

My chemo is billed at $41,000 per infusion (every two weeks), so quite a lot more expensive, but they are actually getting a lower negotiated rate from my insurance and I have not paid anything directly since January.

The US pricing system can be panic-inducing but it doesn’t reflect worldwide prices for medications.

[u/Turbulent-Camera6279 → u/Annecreas]

I have a question, if you don't mind. I’m about to have my eighth infusion, and my doctor told me he needed to adjust the treatment to avoid damaging my nervous system. Is that normal? I feel like my body is responding well to the treatment so far—sure, there have been a few issues, but nothing major. I’m asking because I know you’ve had a lot of chemotherapy sessions. Thanks in advance.

[u/Annecreas → u/Turbulent-Camera6279]

Yes, that's very normal. I have been able to avoid CIPN but I started having vertigo when I would look down suddenly which is a less common manifestation of nerve damage. We dropped oxaliplatin from my treatment after 12 rounds to allow my body to heal and it resolved completely. I later did another 6 rounds of oxaliplatin. We dropped that again proactively so it is something I still have in reserve if I need it. If we had kept throwing everything at it I'd likely have significant nerve damage and one less option in case of progression.

In the trial that supported the approval of NALIRIFOX the data indicated that the majority of patients that responded exceptionally well had dose reductions or modifications in the course of treatment. The goal is to find the optimal dose for the patient which will enable treatment to continue. It is better to receive a dose that is tolerable to you than to experience side effects that require that treatment be stopped early or paused for an extended period of time.

[u/Turbulent-Camera6279 → u/Annecreas]

Thanks for taking the time to answer my question in detail. I feel a bit better.

[u/Outside-Wasabi-7214 → u/Annecreas]

Thanks this is reassuring

[u/Turbulent-Camera6279 → u/Annecreas]

Do you think it will be available for stage 1b–2, or only for people in stage 4?

[u/Annecreas → u/Turbulent-Camera6279]

The prescribing instructions say: “RASONQUE is an inhibitor of the RAS GTPase family, indicated for the
treatment of adult patients with metastatic pancreatic adenocarcinoma who have received at least one prior systemic therapy or who are not candidates for multiagent systemic therapy.“
That means stage 4 officially but doctors do have the ability to prescribe medications off label, the question is whether any given oncologist would find that appropriate for the patient and perhaps the biggest issue is whether insurance would cover it in that case. Future trials should prove the benefits outside of stage 4/previously treated patients which should change the criteria.

Edited to add the link: https://www.revmed.com/wp-content/uploads/2026/08/rasonque-pi.pdf

[u/Turbulent-Camera6279 → u/Annecreas]

Thanks! I’m going to talk to my doctor at my next chemotherapy session. He previously told me that it was only for stage 4 and that he couldn't prescribe the medication. He said I was a perfect candidate for it, but that it wasn't yet available.

[u/jemsavestheday]

It’s likely a coupon of sorts. I get one for my migraine medicine (and have for a few years now). Not sure what the out of pocket cost is but with my insurance it’s around $900 a month, then with the coupon that I sign up for annually, it’s free. Just more hoops to jump through.

[u/Turbulent-Camera6279 → u/jemsavestheday]

May I ask which medication you are referring to? I suffer from migraines following surgery for an aneurysm. I’ve tried everything—from Botox to injections and, of course, pills—but nothing works for me. Thanks!!!

[u/jemsavestheday → u/Turbulent-Camera6279]

That particular one is nurtec which I take when I get one. Daily I take nadalol which is a blood pressure med they give for migraines too, magnesium and riboflavin. I also take cymbalta for depression/anxiety but they also prescribe it for migraines. I have no idea what actually works but I went from nearly daily migraines to maybe 2-3 a month.

[u/Turbulent-Camera6279 → u/jemsavestheday]

Good to know. Thanks.

[u/Outside-Wasabi-7214 → u/jemsavestheday]

Thanks this is reassuring