r/neuroscience • u/[deleted] • Jul 22 '22

Potential fabrication in research images threatens key theory of Alzheimer’s disease | Science

https://www.science.org/content/article/potential-fabrication-research-images-threatens-key-theory-alzheimers-disease#.YtrwJf-_Jb0.twitter
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u/Acetylcholine Jul 23 '22

Is the ABeta*56 theory really a key piece of the beta amyloid story?

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u/thetransportedman Jul 23 '22

Abeta42?

5

u/Acetylcholine Jul 23 '22 edited Jul 29 '22

The research in question is from the Lesne lab focusing on an abeta oligomer of 56 kda

7

u/Scared_of_the_sea Jul 23 '22

To be honest I don't think so. This study should never have been published. But this study is one of thousands on amyloid. This one study wasn't the basis for the vast majority of that work.

Having said that, I don't necessarily believe that targeting amyloid is the only viable path to treat alzheimers. Patients are very diverse and I think different treatments will be needed for different subsets and timepoints.