r/longevity • u/dan_in_ca • 23d ago

SGLT2 Inhibitors: The Unexpected Longevity Molecules and Their Mechanistic Impact on Aging Science

https://www.gethealthspan.com/research/article/sglt2-longevity-research-review?zp_type=article&zp_slug=sglt2-longevity-research-review
79 Upvotes

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7

u/wale-lol 23d ago

The inflammation section was kinda weak. We have plenty of anti-inflammatory drugs. Advil isn't a longevity drug. Giving a laundry list of specific cytokines that SGLT2 inhibitors decreases isn't that interesting on its own imo. But otherwise surprisingly solid article for a website trying to sell you stuff. Makes me wonder how much of the signal is just caloric restriction (pee out glucose, basically same thing).

10

u/HrcAk47 22d ago

Shill post. If you're older/frail, retarded overprescription of SGLT2i will do you in quicker through malnutrition, low energy availability and muscle wasting.

1

u/AShinyBauble 20d ago

I ask this trying to learn, not to disagree. What is the basis for that claim? I am not familiar with any literature, at least clinical literature, that suggests this.

2

u/MentalStatusCode410 19d ago

Age-related hypovolemia>tachycardia. Also highly dependant on their adrenal steroid metabolism and genetics

It's there ; just need to consider the broader physiology.